The culture of care to enhance laboratory animal personnel well-being: a scoping review [0.03%]
一种关怀文化增强实验动物从业人员福祉的综述研究
Heidi L Morahan,Shari Cohen,Lisa Bero et al.
Heidi L Morahan et al.
There has been intense focus on improving the quality of animal research in recent times. An emerging concept of a 'culture of care' has been proposed as another important pillar to enhance scientific quality, with staff well-being being a ...
Spontaneous type II cell-derived bronchioloalveolar adenoma in a young ICR mouse [0.03%]
青年ICR小鼠肺泡管腺瘤1例报告
Minkyoung Sung,Soo-Eun Sung,Joo-Hee Choi et al.
Minkyoung Sung et al.
Although pulmonary adenomas have been reported in ICR mice, spontaneous adenomas have not been reported in mice aged ≤10 weeks. Here, we report a well-circumscribed nodule (1 mm × 1 mm) in the peripheral lesion of the left lateral lobe of...
Refining urine collection in mice: Development of an innovative urine collection device [0.03%]
小鼠尿液收集的改进：创新型尿液收集装置的研发
Mélodie Douté,Céline Monzali,Antonino Nicoletti et al.
Mélodie Douté et al.
Urine collection can be challenging in studies involving small rodents like mice, as the actual methods of collection are anxiogenic and constrain animal welfare while having high variability in the volume of urine collected. To improve the...
Fin clipping does not increase opercular beat rate in tricaine-treated zebrafish [0.03%]
尾鳍切除不会增加三卡因处理的斑马鱼鳃盖膜搏动率
Martin D Burkhalter,Melanie Philipp
Martin D Burkhalter
To carry out research with genetically modified animals, their genotype has to be assessed. A standard protocol to obtain required tissue samples from zebrafish is finclipping. However, some studies reported considerable stress induced by t...
Fulvio Magara,Benjamin Boury-Jamot
Fulvio Magara
Absence of statistical significance (i.e., p > 0.05) in the results of a frequentist test comparing two samples is often used as evidence of absence of difference, or absence of effect of a treatment, on the measured variable. Such conclusi...
Pharmacokinetics of single dose levobupivacaine after peri-incisional subcutaneous infiltration in anaesthetized domestic pigs [0.03%]
单剂量左布比卡因腹腔切口周围皮下浸润给药后麻醉家猪体内的药物代谢动力学特征
Tilen Vake,Tomaž Snoj,Maja Čemažar et al.
Tilen Vake et al.
Increasing use of pigs as models in translational research, and growing focus on animal welfare are leading to better use of effective analgesics and anaesthetics when painful procedures are performed. However, there is a gap in basic knowl...
Pablo Vázquez-Borsetti
Pablo Vázquez-Borsetti
The rat is one of the most employed animal models in biomedicine. Traditionally, weight gain has been utilized to gauge development and compare across species. Numerous studies have conducted longitudinal analyses of rat development, with e...
Treatment randomisation at animal or pen level? : Statistical analysis should follow the randomisation pattern! [0.03%]
个体还是群体随机分组？──统计分析应遵守随机化模式！
Luc Duchateau,Robrecht Dockx,Klara Goethals et al.
Luc Duchateau et al.
Random treatment assignment is essential in demonstrating a causal relationship between a treatment and the outcome of interest. Randomisation ensures that animals assigned to different treatment groups do not differ from each other systema...
Comparison of two bedding types on the breeding fecundity of C57BL/6J mice [0.03%]
两种垫料对C57BL/6J小鼠繁殖性能的影响比较研究
Jessica L Pinckard,Lauren A Gibson,Wendy R Williams
Jessica L Pinckard
One of the favored options for generating complex transgenic laboratory mice is through in-house breeding and management strategies. One consideration in the management of these colonies is how the animals' environment may affect reproducti...
Comparative Study
Laboratory animals. 2024 Dec;58(6):545-551. DOI:10.1177/00236772241249783 2024
Ditching the norm: Using alternative distributions for biological data analysis [0.03%]
摒弃正态分布：生物数据分析中的替代方案
Stanley E Lazic
Stanley E Lazic
Most classical statistical tests assume data are normally distributed. If this assumption is not met, researchers often turn to non-parametric methods. These methods have some drawbacks, and if no suitable non-parametric test exists, a norm...