Cardiopulmonary, echodopplercardiographic and cardiac output effects of isoflurane anaesthesia in male sheep [0.03%]
异氟醚麻醉对公羊心肺、心脏超声以及心排血量的影响
Rauane Sousa de Moura,Beatriz Kawamura Rodrigues,Daianny Pires de Freitas et al.
Rauane Sousa de Moura et al.
Eight male Dorper sheep were anesthetized with isoflurane to evaluate the effects of anesthesia on cardiopulmonary parameters, echocardiographic variables and cardiac output (CO) using echocardiography methods compared with thermodilution. ...
Idiopathic hypereosinophilic syndrome in a female Sprague Dawley rat [0.03%]
一只雌性Sprague-Dawley大鼠的特发性高嗜酸性粒细胞综合症
Elizabeth Lavin,Morgan Shelton,Jeanine Peters-Kennedy et al.
Elizabeth Lavin et al.
An approximately 7.5-month-old female Sprague Dawley rat (Rattus norvegicus) housed in a research facility presented for skin lesions including multifocal crusting and hypotrichosis. On presentation the research rat was mildly underconditio...
Welfare complications in the male BN/Crl and RjHan:SD rat streptozotocin-induced diabetes models [0.03%]
链球菌毒素诱导的BN/Crl和RjHan：SD大鼠糖尿病模型的福利问题复杂性
Anni Tenhunen,Satu Mering,Hanna-Marja Voipio et al.
Anni Tenhunen et al.
The streptozotocin (STZ)-induced hyperglycaemic rat model is widely used in diabetes research, particularly for investigating diabetic retinopathy; however, animal welfare concerns are often underreported. This study evaluated welfare outco...
Introducing entrustable professional activities and competency-based development into workplace-based training within laboratory animal sciences [0.03%]
在实验动物科学领域的工作场所培训中引入可委托的职业活动和基于能力的发展项目
Ivo Tiebosch,Lucy Whitfield,Robert Favier
Ivo Tiebosch
Animals used in science and education should be used by competent laboratory animal science (LAS) staff, both for reasons of reproducibility and to safeguard animal welfare. In this article, we propose entrustable professional activities (E...
Advancing animal welfare: A natural mating protocol for Xenopus laevis [0.03%]
爪蟾(Xenopus laevis)自然交配繁殖方案的建立及推广
Elena Menegola,Francesca Di Renzo,Renato Bacchetta et al.
Elena Menegola et al.
The amphibian Xenopus laevis is an alternative animal model for developmental biology and toxicology. The Frog Embryo Teratogenesis Assay-Xenopus (FETAX) stands as a validated test for ecotoxicology and chemical hazard characterization. Con...
Conspecific images require longer visual processing than simple stimuli in healthy four-week old piglets [0.03%]
健康4周龄猪let处理同种图片需要更长的视觉处理时间_than_simple_stimuli
R Anna Oeur,Susan S Margulies
R Anna Oeur
Swine are a common neurobehavioral model. Visual event related potentials (VERPs) are an electroencephalogram (EEG) technique that assesses visual processing and can inform brain function and sensory changes after trauma or disease. We hypo...
Antinociceptive and motor-blocking effects of epidurally administered diphenhydramine at different concentrations in conscious rabbits: a randomized-controlled trial [0.03%]
不同浓度意识家兔腰椎硬膜外给药马来酸氯苯那敏的镇痛及运动阻滞效果：随机对照试验
Navid Ziaei-Darounkolaei,Ismael Hernández-Ávalos,Vahid Vahedian et al.
Navid Ziaei-Darounkolaei et al.
In this study we aimed to determine the optimal epidural dose and concentration of diphenhydramine (DPH) for prolonged analgesia while preserving motor function, comparing its effects with lidocaine. A single-blind, randomized-controlled tr...
Megan D Higgs,Valentin Amrhein
Megan D Higgs
Researchers often need to justify their choice of sample size, particularly in fields such as animal and clinical research, where there are obvious ethical concerns about relying on too many or too few study subjects. The common approach is...
A simple and rapid shaking-based assay to genotype live, early developmental stage zebrafish embryos [0.03%]
一种简单快速的摇晃检测法用于活体斑马鱼早期胚胎基因型鉴定
Rima Siauciuinate,Christelle Etard,Almut Koehler et al.
Rima Siauciuinate et al.
The use of zebrafish as an animal model for biomedical and toxicological research has increased dramatically over the past decade, alongside a growing need to adopt the 3Rs principles to ensure ethically acceptable animal experimentation. C...
Methods of humane killing of laboratory fish: FELASA Working Group recommendations [0.03%]
实验鱼的人道安乐死方法：FELASA工作组建议
Jean-Philippe Mocho,Juan Ramos Blasco,Pia Rengtved Lundegaard et al.
Jean-Philippe Mocho et al.
As commissioned by the Federation of European Laboratory Animal Science Associations, these working group recommendations define the requirements to achieve the humane killing of fish, compare methods of killing, recommend methods of killin...