Russell Whelan,Daniel Lih,Jun Xue et al.
Russell Whelan et al.
Shiga toxin (Stx) causes significant renal microvascular injury and kidney failure in the pediatric population, and an effective targeted therapy has yet to be demonstrated. Here we established a human kidney microvascular endothelial cell ...
Microdroplet co-cultivation and interaction characterization of human vaginal bacteria [0.03%]
人阴道细菌的微滴共培养及相互作用特征分析
Corine M Jackman,Kyle W Deans,Larry J Forney et al.
Corine M Jackman et al.
The human vaginal microbiome (HVM) plays a fundamental role in women's reproductive health. For instance, bacterial vaginosis (BV) is characterized by a depletion of lactobacilli and an overgrowth of strict anaerobes. Women with BV may have...
Protein dynamic analysis of the budding yeast sporulation process at the single-cell level in an air-enriched microfluidic device [0.03%]
一种富氧微流控装置中的单细胞水平蛋白动态分析技术——以芽殖酵母孢子形成过程为例
Xiang Zhao,Chunxiong Luo,Hongli Wang
Xiang Zhao
The sporulation process of the budding yeast Saccharomyces cerevisiae involves morphological changes, which is a complex and interesting process in yeast biology. However, efficient methods to accurately study protein dynamic behaviors in t...
Dual functionality of pyrimidine and flavone in targeting genomic variants of EGFR and ER receptors to influence the differential survival rates in breast cancer patients [0.03%]
嘧啶和黄酮的双重功能靶向EGFR和ER受体的基因组变异以影响乳腺癌患者的生存率差异
Pramod K Avti,Jitender Singh,Divya Dahiya et al.
Pramod K Avti et al.
Breast cancer ranks as one of the most prevalent forms of cancer and stands as the primary global cause of mortality among women. Overexpression of EGFR and ER receptors or their genomic alterations leads to malignant transformation, diseas...
Human enteroids as a tool to study conventional and ultra-high dose rate radiation [0.03%]
人源类器官作为研究常规和超高剂量率辐射的工具
Katarina C Klett,Briana C Martin-Villa,Victoria S Villarreal et al.
Katarina C Klett et al.
Radiation therapy, one of the most effective therapies to treat cancer, is highly toxic to healthy tissue. The delivery of radiation at ultra-high dose rates, FLASH radiation therapy (FLASH), has been shown to maintain therapeutic anti-tumo...
Preliminary study to identify CXCR4 inhibitors as potential therapeutic agents for Alzheimer's and Parkinson's diseases [0.03%]
初步研究：鉴定CXCR4抑制剂作为阿尔茨海默病和帕金森病潜在治疗药物
Rahul Tripathi,Pravir Kumar
Rahul Tripathi
Neurodegenerative disorders (NDDs) are known to exhibit genetic overlap and shared pathophysiology. This study aims to find the shared genetic architecture of Alzheimer's disease (AD) and Parkinson's disease (PD), two major age-related prog...
Collagen microgel to simulate the adipocyte microenvironment for in vitro research on obesity [0.03%]
用于体外肥胖研究的模拟脂肪细胞微环境的胶原蛋白微凝胶
Natalia Moreno-Castellanos,Elías Cuartas-Gómez,Oscar Vargas-Ceballos
Natalia Moreno-Castellanos
Obesity is linked to adipose tissue dysfunction, a dynamic endocrine organ. Two-dimensional cultures present technical hurdles hampering their ability to follow individual or cell groups for metabolic disease research. Three-dimensional typ...
A high-throughput sensory assay for parasitic and free-living nematodes [0.03%]
一种针对寄生性和自由生活的线虫的高通量感觉测定法
Leonardo R Nunn,Terry D Juang,David J Beebe et al.
Leonardo R Nunn et al.
Sensory pathways first elucidated in Caenorhabditis elegans are conserved across free-living and parasitic nematodes, even though each species responds to a diverse array of compounds. Most nematode sensory assays are performed by tallying ...
Continuum interpretation of mechano-adaptation in micropatterned epithelia informed by in vitro experiments [0.03%]
基于体外实验的微图案上皮中机械适应的连续介质解释
Bernard L Cook,Patrick W Alford
Bernard L Cook
Epithelial tissues adapt their form and function following mechanical perturbations, or mechano-adapt, and these changes often result in reactive forces that oppose the direction of the applied change. Tissues subjected to ectopic tensions,...
Dynamic modelling predicts lactate and IL-1β as interventional targets in metabolic-inflammation-clock regulatory loop in glioma [0.03%]
动态建模预测乳酸和IL-1β作为代谢-炎症-时钟调节回路的干预靶点以治疗胶质瘤
Shalini Sharma,Pruthvi Gowda,Kirti Lathoria et al.
Shalini Sharma et al.
In an attempt to understand the role of dysregulated circadian rhythm in glioma, our recent findings highlighted the existence of a feed-forward loop between tumour metabolite lactate, pro-inflammatory cytokine IL-1β and circadian CLOCK. T...