Pharmaco-Epigenomic response of Pimozide is mediated through miR-2909 [0.03%]
匹莫齐的药表观遗传学反应通过miR-2909介导
Deepti Malik,Ashvinder Raina,Jitender Singh et al.
Deepti Malik et al.
A recent study delves into intricate relationship between microRNAs (miRNAs), specifically focusing on their role in cancer development. miRNAs are highlighted for their capacity to modify genetic profile and modulate epigenetic architectur...
Integrated bioinformatics analysis reveals cytokine dysregulation, pathway alterations, and machine learning identification of diagnostic biomarkers in sepsis [0.03%]
整合生物信息学分析揭示了脓毒症中细胞因子失调、途径改变及诊断生物标志物的机器学习识别方法
Weili Jiang,Jianning Rong,Wenwen Han et al.
Weili Jiang et al.
Sepsis, a life-threatening dysregulated host response to infection, involves complex cytokine signaling. Comprehensive bioinformatics analysis of cytokine activity, associated pathways, and immune alterations in sepsis is warranted. Using t...
Adaptation to solvent environment in toll-like receptor 5: kernel-based evolutionary analysis of membrane-bound and soluble forms in Epinephelus coioides [0.03%]
基于核的算法对真鲷 Toll 样受体 5 膜结合型和可溶型适应溶剂环境的进化分析
Alper Karagöl,Taner Karagöl
Alper Karagöl
Toll-like receptor 5 (TLR5) is a conserved member of the innate immune system and known for its ability to detect bacterial flagellin. Interestingly, the orange-spotted grouper (Epinephelus coioides), possess both membrane-bound (mTLR5) and...
Trim45 promotes the occurrence and development of cervical cancer by inhibiting the cGAS/STING signaling pathway [0.03%]
TRIM45通过抑制cGAS/STING信号通路促进宫颈癌的发生发展
Huhu Zhang,Xi Chen,Banghui Wang et al.
Huhu Zhang et al.
Cervical cancer is a gynecological malignancy closely associated with high-risk human papillomavirus infection. Trim45, a member of the E3 ubiquitin ligase family, is highly expressed in cervical cancer tissues; however, its specific mechan...
Predicting gut metabolites from gut microbiome and their interpretability analysis of IBD prediction based on LIME [0.03%]
基于LIME的IBD预测的肠道代谢物预测及其可解释性分析
Jing Liu,Kun Li,Yu Zhang et al.
Jing Liu et al.
The pathophysiology of inflammatory bowel disease (IBD) is influenced by the gut microbiome and gut metabolite, but understanding how IBD is affected remains challenging. It is crucial to understand which features affect IBD in order to eff...
Molecular and pharmacological impacts of phytochemicals on the enoyl-acyl carrier protein reductase: potential therapeutic implications in tuberculosis [0.03%]
植物化学物质对烯酰基-酰基载体蛋白还原酶的分子和药理影响：治疗结核病的潜在作用机制
Mony Thakur,Bhanu Pratap Gurjar,Khushboo et al.
Mony Thakur et al.
Tuberculosis (TB) remains a major global health challenge, necessitating the development of novel therapeutic interventions. Enoyl-acyl carrier protein (ACP) reductase (InhA), a key enzyme in the fatty acid biosynthesis pathway of Mycobacte...
DNMT1 stabilizes MAPK10 via m5C RNA methylation to ameliorate hepatic steatosis and mitochondrial dysfunction in non-alcoholic fatty liver disease [0.03%]
DNA甲基化转移酶DNMT1通过mRNA上m5C修饰稳定MAPK10缓解非酒精性脂肪肝病中的肝脏脂质蓄积和线粒体功能障碍
Jing Liu,Chuang Liu,Huanzhi Xiao et al.
Jing Liu et al.
Background: Non-alcoholic fatty liver disease (NAFLD) represents a highly prevalent metabolic disorder; however, the functional role of mitogen-activated protein kinase 10 (MAPK10) in the initiation and progression of NAF...
MARCH1 attenuates lung adenocarcinoma by blocking macrophage M2 polarization and cisplatin resistance through reducing SLC25A17 stability [0.03%]
MARCH1通过降低SLC25A17稳定性来抑制巨噬细胞M2极化和顺铂耐药从而抑制肺腺癌的发展
Huifeng Wang,Yanyan Sun,Rui Zi et al.
Huifeng Wang et al.
Cisplatin (DDP) resistance constitutes a major obstacle associated with poor prognosis in patients with lung adenocarcinoma (LUAD). Membrane-associated RING-CH finger protein 1 (MARCH1) contributed to shaping an inflamed tumor microenvironm...
Delineating the interactions among mutual miRNAs and target genes associated with Parkinson's disease, endoplasmic reticulum stress and autophagy pathways: a computational analysis [0.03%]
计算分析界定与帕金森病、内质网应激和自噬途径相关的互斥miRNA和靶基因的相互作用
Lakshmi Sankaranarayanan,Jagan Muniyandi,Yerragudi Saicharan Reddy et al.
Lakshmi Sankaranarayanan et al.
MicroRNAs have been implicated in the pathophysiology of several diseases including Parkinson's disease (PD). Endoplasmic reticulum (ER) stress mediated unfolded protein response (UPR) pathway and autophagy play a vital role in preventing t...
Application of interpretable machine learning to analyze DNA methylation sites in the progression from oral Leukoplakia to oral squamous cell carcinoma [0.03%]
可解释机器学习在口腔黏膜白斑癌变过程中DNA甲基化位点分析中的应用研究
Khushi Yadav,Yasha Hasija
Khushi Yadav
Epigenetic alterations, particularly DNA methylation, play a crucial role in the progression of oral squamous cell carcinoma (OSCC) from oral leukoplakia (OL). However, the molecular mechanisms driving this transition remain poorly understo...