Effect of Si Jun Zi tang on premature ovarian failure through regulation of ROCK1/PTEN/PI3K/Akt pathway [0.03%]
Si Jun Zi汤通过调节ROCK1/PTEN/PI3K/Akt途径对卵巢早衰的影响
Xinbin Wang,Haorui Wang,Jing Li et al.
Xinbin Wang et al.
Background: The main cause of decreased or absent female fertility is a complex, heterogeneous condition known as premature ovarian failure (POF). Surprisingly, POF can be effectively treated using traditional Chinese med...
Immune, metabolic, and steroidogenesis-associated profiles of miR-940, miR-375, and miR-326 in adrenocortical carcinoma [0.03%]
微RNA-miR-940、miR-375和miR-326在肾上腺皮质癌中的免疫、代谢及类固醇激素生成相关谱型分析
Javad Omidi
Javad Omidi
Adrenocortical carcinoma (ACC) has remained a highly aggressive endocrine malignancy characterized by extensive molecular heterogeneity and limited therapeutic options. In the present study, the regulatory significance of hsa-miR-940, hsa-m...
Bivalency of natalizumab promotes inhibition of dynamic VLA-4 adhesion beyond affinity gain [0.03%]
纳他珠单抗的双稳态性可促进其以超越亲和力获得的方式抑制动态VLA-4粘附作用
Marie-Pierre Valignat,Martine Biarnes-Pelicot,Dominique Touchard et al.
Marie-Pierre Valignat et al.
Natalizumab, a monoclonal IgG4 antibody used in the treatment of multiple sclerosis (MS), inhibits α4β1 (very late antigen-4, VLA-4)-binding to vascular cell adhesion molecule-1 (VCAM-1), thereby reducing leukocyte recruitment to inflamed...
Potential therapeutic targets for obstructive sleep Apnea were identified through network pharmacology, WGCNA, machine learning, immune infiltration analysis, and ceRNA network [0.03%]
通过网络药理学、WGCNA、机器学习、免疫浸润分析和ceRNA网络识别阻塞性睡眠呼吸暂停的潜在治疗靶点
Fengwei Xie,Dikun Zhu,Zhitong Yang et al.
Fengwei Xie et al.
Background: Our study aims to explore the early genomic diagnostic markers of OSA and the corresponding drug prediction targets using network pharmacology analysis, and to elucidate the etiology and pathogenesis of OSA fr...
Engineered lymphatic stroma model applications in central nervous system leukemia [0.03%]
工程化淋巴管基质模型在中枢神经系统白血病中的应用
Jennifer H Hammel,Hailey E Murphy,Khadijat O Oyediran et al.
Jennifer H Hammel et al.
Central nervous system (CNS) involvement frequently occurs in acute lymphoblastic leukemia (ALL), but many questions remain about how leukemia cells access, persist in, and exploit the CNS. The CNS is protected by the meninges, which are fl...
Pharmaco-Epigenomic response of Pimozide is mediated through miR-2909 [0.03%]
匹莫齐的药表观遗传学反应通过miR-2909介导
Deepti Malik,Ashvinder Raina,Jitender Singh et al.
Deepti Malik et al.
A recent study delves into intricate relationship between microRNAs (miRNAs), specifically focusing on their role in cancer development. miRNAs are highlighted for their capacity to modify genetic profile and modulate epigenetic architectur...
Integrated bioinformatics analysis reveals cytokine dysregulation, pathway alterations, and machine learning identification of diagnostic biomarkers in sepsis [0.03%]
整合生物信息学分析揭示了脓毒症中细胞因子失调、途径改变及诊断生物标志物的机器学习识别方法
Weili Jiang,Jianning Rong,Wenwen Han et al.
Weili Jiang et al.
Sepsis, a life-threatening dysregulated host response to infection, involves complex cytokine signaling. Comprehensive bioinformatics analysis of cytokine activity, associated pathways, and immune alterations in sepsis is warranted. Using t...
Adaptation to solvent environment in toll-like receptor 5: kernel-based evolutionary analysis of membrane-bound and soluble forms in Epinephelus coioides [0.03%]
基于核的算法对真鲷 Toll 样受体 5 膜结合型和可溶型适应溶剂环境的进化分析
Alper Karagöl,Taner Karagöl
Alper Karagöl
Toll-like receptor 5 (TLR5) is a conserved member of the innate immune system and known for its ability to detect bacterial flagellin. Interestingly, the orange-spotted grouper (Epinephelus coioides), possess both membrane-bound (mTLR5) and...
Trim45 promotes the occurrence and development of cervical cancer by inhibiting the cGAS/STING signaling pathway [0.03%]
TRIM45通过抑制cGAS/STING信号通路促进宫颈癌的发生发展
Huhu Zhang,Xi Chen,Banghui Wang et al.
Huhu Zhang et al.
Cervical cancer is a gynecological malignancy closely associated with high-risk human papillomavirus infection. Trim45, a member of the E3 ubiquitin ligase family, is highly expressed in cervical cancer tissues; however, its specific mechan...
Predicting gut metabolites from gut microbiome and their interpretability analysis of IBD prediction based on LIME [0.03%]
基于LIME的IBD预测的肠道代谢物预测及其可解释性分析
Jing Liu,Kun Li,Yu Zhang et al.
Jing Liu et al.
The pathophysiology of inflammatory bowel disease (IBD) is influenced by the gut microbiome and gut metabolite, but understanding how IBD is affected remains challenging. It is crucial to understand which features affect IBD in order to eff...