Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists [0.03%]
奇妙的RNA编辑复合物RECC、RESC和REH2C：顶鞭亚纲原生动物中的功能组织、发育调控及进化历史
Suzanne M McDermott,Julius Lukeš,Laurie K Read et al.
Suzanne M McDermott et al.
RNA metabolism in kinetoplastid protists (Kinetoplastea), including trypanosomes and Leishmania, involves unique post-transcriptional mitochondrial RNA editing that creates translatable mRNAs through uridine (U) insertions and deletions (U-...
MiRNA Stability and Degradation: Dynamic Regulators of Cellular Regulatory Networks [0.03%]
微小核糖核酸的稳定性与降解：细胞调控网络的动力调节因子
Ziqi Lin,Weijie Wen,Muhammad Irfan et al.
Ziqi Lin et al.
MicroRNAs (miRNAs) are pivotal post-transcriptional regulators of gene networks in development and disease, with their functional output critically dependent on dynamic turnover. Dysregulation of miRNA turnover disrupts signaling fidelity a...
William F Marzluff
William F Marzluff
Each time a eucaryotic cell divides, it replicates its DNA and packages the DNA into chormatin. Large amounts of all five histone proteins are co-ordinately synthesized to assemble the newly replicated chromatin. The metazoan replication-de...
Comprehensive Overview of Computational Tools for Alternative Splicing Analysis [0.03%]
备选剪接分析的计算工具概述
Hieu Tran,Nirad Banskota,Myriam Gorospe et al.
Hieu Tran et al.
Alternative splicing (AS) is a fundamental mechanism that generates transcriptomic diversity by selectively including or excluding exons and introns from pre-mRNA transcripts, leading to the production of multiple protein isoforms from a si...
Farnaz Mansouri-Noori,Mark A Bayfield
Farnaz Mansouri-Noori
La and La-related proteins (LARPs) are conserved RNA-binding proteins that share a characteristic La motif (LaM) and have important functions in RNA metabolism. Members of the LARP1 family bind a cohort of mRNAs encoding factors involved in...
Shu Jun Lin,Esperanza Rosas,Gabriele Fuchs et al.
Shu Jun Lin et al.
Eukaryotic gene expression is strictly controlled and regulated during translation. For eukaryotic mRNAs, canonical cap-dependent translation is the preferred pathway to synthesize proteins and starts with the recruitment of eukaryotic init...
XiaoLing Chen,Quandan Tan,GuoLiang Zhu et al.
XiaoLing Chen et al.
This article reviews the potential role of glycosylated RNA (glycoRNA), a new form of RNA epigenetic modification, in diseases. GlycoRNA has two types of modifications, N-glycosylation and O-glycosylation, and is widely present on the surfa...
Mixed Messages: Dynamic and Compositional Heterogeneity of Nuclear Messenger Ribonucleoprotein (mRNP) Complexes [0.03%]
混合消息：核内信使核糖核蛋白（mRNP）复合物的动态和组成异质性
Theresa Wechsler,Ryuta Asada,Ben Montpetit
Theresa Wechsler
Messenger ribonucleoprotein (mRNP) complexes assemble co-transcriptionally in the nucleus as RNA-binding proteins (RBPs) engage nascent transcripts. Ongoing RNA processing and RBP dynamics generate a diverse set of mRNPs, often producing a ...
Dan Zhao,Yifei Wang
Dan Zhao
Cancer remains one of the leading causes of death worldwide. Despite various efforts to reduce cancer mortality, such as decreasing tobacco use, improving early detection and prevention methods, and enhancing cancer care and treatments, cer...
Ericks S Soares,Caio Bruno Q S Leal,Vanessa V C Sinatti et al.
Ericks S Soares et al.
The U1 small nuclear ribonucleoprotein (snRNP) complex is crucial for pre-mRNA splicing and the regulation of gene expression. As a core component of the spliceosome, it is responsible for recognizing 5'-splice sites and initiating the spli...