Exploring New Frontiers in Bone Metabolism: Role and Potential of lncRNA DANCR [0.03%]
骨代谢新前沿：长链非编码 RNA DANCR 的作用和潜能探索
Mianmian Yang,Ruiqi Huang,Ruiming Wen et al.
Mianmian Yang et al.
As an emerging epigenetic regulator, differentiation-antagonizing long-chain noncoding RNA (lncRNA) plays multiple roles in bone metabolism regulation and bone-related diseases. We found that lncRNA DANCR regulates bone metabolism by inhibi...
Functional Inclusion of RNA Biology in the Tethered Extracellular Matrix [0.03%]
拴系型细胞外基质中功能性纳入RNA生物学
Peiyuan Chai,Ryan A Flynn
Peiyuan Chai
RNA biology is traditionally confined to the cytosolic and nuclear spaces, where it plays critical roles across nearly all biochemical processes. Our recent observation of spatiotemporal regulation of cell surface ribonucleoproteins, consis...
Structural and Functional Diversity of RNA-Containing Toxin-Antitoxin Systems [0.03%]
含RNA的毒蛋白系统结构和功能多样性
Harshita Dutta,Salik Noor,Kavyashree Nadig et al.
Harshita Dutta et al.
Toxin-antitoxin (TA) systems are ubiquitous prokaryotic genetic modules located on plasmids and chromosomes, contributing to plasmid stabilization, maintenance of genome integrity, phage defense, and bacterial pathogenesis. Canonically, the...
Promoter-Targeting RNA Technologies: An Epigenetic Strategy for Gene Activation and Gene Silencing [0.03%]
靶向启动子的RNA技术：一种用于基因激活和基因沉默的表观遗传策略
Rajat Hegde,Maryam Abdul Ajees,Kedlaya Srikrishna H Damodar et al.
Rajat Hegde et al.
Promoter-targeted RNAs (PTRs) are emerging as a transformative approach for future therapeutics, offering the ability to directly modulate gene expression at the transcriptional level. Unlike traditional RNA-based methods that work post tra...
Xiaohui Wang,Henan Zhang,Fang Chen et al.
Xiaohui Wang et al.
lncRNAs are a group of RNA molecules with over 200 nucleotides involved in many biological processes. The dysregulation of lncRNA has been covered in several processes related to carcinogenesis, such as proliferation, apoptosis, invasion, e...
Hui Chen,Yi Du,Yesheng Wang et al.
Hui Chen et al.
Endogenous circRNAs play crucial physiological roles within organisms and hold significant potential as biomarkers for disease diagnosis, prognosis, and therapeutic targeting. The closed-loop structure of circRNAs confers unique advantages ...
Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists [0.03%]
奇妙的RNA编辑复合物RECC、RESC和REH2C：顶鞭亚纲原生动物中的功能组织、发育调控及进化历史
Suzanne M McDermott,Julius Lukeš,Laurie K Read et al.
Suzanne M McDermott et al.
RNA metabolism in kinetoplastid protists (Kinetoplastea), including trypanosomes and Leishmania, involves unique post-transcriptional mitochondrial RNA editing that creates translatable mRNAs through uridine (U) insertions and deletions (U-...
MiRNA Stability and Degradation: Dynamic Regulators of Cellular Regulatory Networks [0.03%]
微小核糖核酸的稳定性与降解：细胞调控网络的动力调节因子
Ziqi Lin,Weijie Wen,Muhammad Irfan et al.
Ziqi Lin et al.
MicroRNAs (miRNAs) are pivotal post-transcriptional regulators of gene networks in development and disease, with their functional output critically dependent on dynamic turnover. Dysregulation of miRNA turnover disrupts signaling fidelity a...
William F Marzluff
William F Marzluff
Each time a eucaryotic cell divides, it replicates its DNA and packages the DNA into chormatin. Large amounts of all five histone proteins are co-ordinately synthesized to assemble the newly replicated chromatin. The metazoan replication-de...
Comprehensive Overview of Computational Tools for Alternative Splicing Analysis [0.03%]
备选剪接分析的计算工具概述
Hieu Tran,Nirad Banskota,Myriam Gorospe et al.
Hieu Tran et al.
Alternative splicing (AS) is a fundamental mechanism that generates transcriptomic diversity by selectively including or excluding exons and introns from pre-mRNA transcripts, leading to the production of multiple protein isoforms from a si...