Mesenchymal stromal cell-derived membrane particles suppress kidney fibrosis [0.03%]
间充质基质细胞衍生的细胞膜颗粒可抑制肾纤维化
Shengbing Li,Ana Merino,Sander Korevaar et al.
Shengbing Li et al.
Background: Kidney injury, typically accompanied by inflammation, is a driver for kidney fibrosis, which contributes to the development of kidney failure. Mesenchymal stromal cells (MSC) have been proposed to have anti-fi...
Human embryonic stem cell-derived Sertoli cells as an immune modulator of cell transplantation therapy in a diabetic mice model [0.03%]
人胚胎干细胞来源的生精细胞支持细胞作为免疫调节因子在糖尿病小鼠模型中的细胞移植治疗中的作用
Jeoung Eun Lee,Chang Woo Lee,A-Reum Han et al.
Jeoung Eun Lee et al.
Objective: Sertoli cells (SCs) are somatic cells that are a part of the seminiferous tubules in the testes and support germ cell development and maturation. Additionally, SCs play another role in protecting male germ cell...
Ultrasound assisted homing of human umbilical cord mesenchymal stem cells promotes recovery from acute respiratory distress syndrome [0.03%]
超声引导人类脐带间充质干细胞移植促进急性肺损伤修复功能
Bei-Ying Wang,Xiao Zhang,Ting-Tian Li et al.
Bei-Ying Wang et al.
Background: Human umbilical cord mesenchymal stem cells (hUC-MSCs) show potential for treating acute respiratory distress syndrome (ARDS), however, their homing to the lungs and survival time are insufficient. In this stu...
Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis [0.03%]
脉冲电磁刺激通过上调胆固醇生物合成促进神经元成熟
Ping Chen,Jingyi Li,Vsevolod Telezhkin et al.
Ping Chen et al.
Background: Stem cell therapies have emerged as transformative therapeutic strategies for neurological disorders. However, neurons derived from transplanted stem cells often exhibit low survival rates and remain in an imm...
NEXN deficiency leads to dilated cardiomyopathy in human pluripotent stem cell-derived cardiomyocytes [0.03%]
NEXN缺陷导致人类多能干细胞源性心肌细胞扩张型心肌病
Mengqi Jiang,Xi Chen,Yuanxiu Song et al.
Mengqi Jiang et al.
Background: Dilated cardiomyopathy (DCM) constitutes a major cause of heart failure, characterized by high mortality rates and a limited availability of effective therapeutic options. A substantial body of evidence indica...
Metabolism-related gene PDK1 regulates myocardial cell remodeling and its mechanism [0.03%]
代谢相关基因PDK1调控心肌细胞重塑及其机制研究
Saleem Amina,Mingyu Wei,Siyao Zhang et al.
Saleem Amina et al.
Background: The progression of ischemic heart disease results from various forms of cardiomyopathies, which begin with cardiac remodelling. Pyruvate Dehydrogenase Kinase 1 (PDK1) is one of the basic kinase family componen...
Advances in mesenchymal stem cell and exosome-based therapies for aging and age-related diseases [0.03%]
基于间充质干细胞和外泌体的抗衰老及治疗年龄相关性疾病疗法进展
Hang Li,Lin Bai
Hang Li
Mesenchymal stem/stromal cells (MSCs) and their exosomes (MSC-Exos) have great potential for tissue repair and regenerative medicine, which can improve the symptoms and prognosis of aging-related diseases and potentially slow the aging proc...
Correction: Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway [0.03%]
纠正：葡聚糖硫酸盐通过激活Wnt信号通路抑制ICAM1表达联合低表达E-钙粘着蛋白防止人类多能干细胞在3D培养中过度聚集
Haibin Wu,Xianglian Tang,Yiyu Wang et al.
Haibin Wu et al.
Published Erratum
Stem cell research & therapy. 2025 Jul 26;16(1):400. DOI:10.1186/s13287-025-04530-z 2025
Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation [0.03%]
视网膜移植后光感受器前体细胞的代谢压力和早期细胞死亡
Raghavi Sudharsan,Natalia Dolgova,Jennifer Kwok et al.
Raghavi Sudharsan et al.
Background: Progressive photoreceptor loss in retinal degenerative diseases leads to irreversible vision impairment. Transplantation of human embryonic or induced pluripotent stem cell-derived photoreceptor precursor cell...
From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery [0.03%]
从炎症到愈合：GPR91激活和SDH抑制在慢性糖尿病伤口恢复中的关键作用
Hengdeng Liu,Shixin Zhao,Hanwen Wang et al.
Hengdeng Liu et al.
Background: Diabetic foot ulcers (DFU) typically exhibit impaired healing due to dysregulated re-epithelialization and excessive inflammation. Succinate, a key metabolic intermediate, is now understood to regulate inflamm...