Geometrical constraints dictate assembly and phenotype of human iPSC-derived motoneuronal spheroids [0.03%]
几何约束决定了由人类多能干细胞衍生的运动神经元球体的组装和表型
Eleonora Mello,Stefano Sorrentino,Alessio Bucciarelli et al.
Eleonora Mello et al.
Background: Neuronal spheroids represent an easy and versatile solution to model neuronal tissue in vitro. Conventional approaches to generate spheroids lack accurate size control, scalability, and customizability. This i...
Inhibition of miR-615-3p enhances dentinogenesis in scaps via PVT1-mediated mitochondrial regulation [0.03%]
miR-615-3p抑制通过PVT1介导的线粒体调节促进SCAPs成牙本质分化
Haoqing Yang,Yishu Huang,Jiaxin Song et al.
Haoqing Yang et al.
Background: Mesenchymal stem cells (MSCs) are critical for dental tissue regeneration, yet their differentiation potential is tightly regulated by microRNAs (miRNAs). This study aimed to investigate the role of miR-615-3p...
In vitro biomimetic models for respiratory diseases: progress in lung organoids and lung-on-a-chip [0.03%]
基于呼吸系统疾病的器官芯片与类器官模型研究进展
Xiaochun Zhang,Haolin Liu,Haofeng Cheng et al.
Xiaochun Zhang et al.
Respiratory diseases pose a growing global public health challenge due to their rising incidence and mortality. Conventional cellular and animal models fall short in replicating the complex three-dimensional (3D) microenvironments of the lu...
Apoptotic vesicles of mesenchymal stem cells promote M2 polarization and alleviate early-onset preeclampsia via miR-191-5p [0.03%]
间充质干细胞凋亡小体通过miR-191-5p促进M2极化以缓解子痫前期
Ling Li,Xu Lu,Qinghai Lian et al.
Ling Li et al.
Background: Macrophages play a crucial role in the development of early-onset preeclampsia (EOPE), which may be closely associated with an imbalance in macrophage M1/M2 polarization. Mesenchymal stem cell (MSC)-derived ap...
Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems [0.03%]
通过共培养系统揭示诱导多能干细胞衍生的成纤维细胞中特定组织的转录适应性
Amar J Azad,Alessandro Bentivogli,Henrike Germar et al.
Amar J Azad et al.
Background: Induced pluripotent stem cell-derived fibroblasts (iFBs) hold promise for autologous disease modelling, but their ability to replicate tissue-specific fibroblast characteristics remains unclear. Fibroblasts ex...
Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis by inhibiting hepatocyte ferroptosis and macrophage polarization via the miR-455-3p/PLAU axis [0.03%]
人源脐带间充质干细胞通过miR-455-3p/PLAU轴抑制肝细胞铁死亡和巨噬细胞极化从而改善肝纤维化
Yong Zhang,Jin Dou,Shipeng Dai et al.
Yong Zhang et al.
Background: Peripheral infusion of human umbilical cord mesenchymal stem cells (hUC-MSCs) may therapeutically treat liver fibrosis. hUC-MSCs can influence liver fibrosis progression and immune microenvironment remodeling ...
Human umbilical cord-derived mesenchymal stromal cell exosomes ameliorate aging-associated skeletal muscle atrophy and dysfunction in SAMP10 mice [0.03%]
人源脐带间充质干细胞外泌体改善SAMP10小鼠与衰老相关的肌肉萎缩和功能障碍
Zhe Huang,Limei Piao,Xiangkun Meng et al.
Zhe Huang et al.
Background: Loss of skeletal muscle mass and function in aging individuals is closely linked to physical deterioration and disability. Because exosomes of human umbilical cord-derived mesenchymal stem cells (hucMSC-Exos) ...
Loss of G-protein coupled receptor 68 in hematopoietic tissues enhances long-term hematopoietic stem cell function upon aging [0.03%]
造血组织中G蛋白偶联受体68的丧失可增强衰老时长期造血干细胞功能
Xiaofei He,Caleb Hawkins,Lauren Lawley et al.
Xiaofei He et al.
Background: G-protein coupled receptor 68 (Gpr68) was enriched in long-term hematopoietic stem cells, indicating a potential role of Gpr68 in the HSC function. However, there is no significant phenotype in the HSC biology...
Intranasal administration of stem cell derivatives for the treatment of AD animal models: a systematic review and meta-analysis [0.03%]
鼻内给药治疗AD动物模型的干细胞衍生物系统的回顾和元分析研究
Zilin Hua,Nan Zhou,Zijing Zhou et al.
Zilin Hua et al.
Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with increasing prevalence and limited efficacy of current therapies. Stem cell-derived therapies have attracted attention for their potential neurodeg...
SMAD3 and HIF-1α orchestrate metabolic transition to aerobic glycolysis as a critical prerequisite for spontaneous reprogramming of spermatogonial stem cells [0.03%]
SMAD3和HIF-1α共同作用促进代谢转换为有氧糖酵解以作为雄性生殖细胞诱导获得 pluripotency的关键前提条件
Yihui Cai,Jian Wen,Hongyang Liu et al.
Yihui Cai et al.
Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why the addition of epidermal growth factor (EGF), leukemia in...