Stem cell-derived exosomes in complicated urinary tract infections: immunomodulatory mechanisms and potential therapeutic strategies for urothelial repair [0.03%]
间充质干细胞来源的外泌体在复杂性尿路感染中发挥免疫调节机制及修复尿路上皮潜能的研究进展
Wenjing Wang,Yong He,Henghui Zhang et al.
Wenjing Wang et al.
Complicated urinary tract infection (cUTI), characterized by recurrent episodes due to multidrug-resistant bacterial infections and biofilm formation, severely compromises patients' quality of life. Although uropathogenic Escherichia coli r...
A scalable platform for EPSC-Induced MSC extracellular vesicles with therapeutic potential [0.03%]
一种可扩展的平台：具有治疗潜力的EPSC诱导的间充质干细胞外泌体
Shixin Gong,Nan Li,Qinqing Peng et al.
Shixin Gong et al.
Background: Extracellular Vesicles (EVs) derived from mesenchymal stem cells (MSCs) have gained recognition as promising therapeutic and drug delivery agents in regenerative medicine. However, their clinical application i...
Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency [0.03%]
利用脂肪源性干细胞的外泌体治疗4-乙烯基环己烯二醇诱导的早发性卵巢功能不全
Yanquan Li,Feng Chen,Wei Zhao et al.
Yanquan Li et al.
Background: Premature ovarian insufficiency (POI) is a challenging condition with limited effective treatments. Adipose-derived stem cells (ADSCs) have demonstrated potential in tissue repair, and their extracellular vesi...
Repair of infarcted myocardium by skeletal muscle-derived mesenchymal stromal cells delivered by a bioprinted collagen patch [0.03%]
生物打印胶原蛋白贴片递送骨骼肌来源的间充质基质细胞修复心肌梗死区
Rose Guesdon,Serena Santoro,Audrey Cras et al.
Rose Guesdon et al.
Mesenchymal stromal cells (MSC) are commonly investigated for post-infarction cardiac repair because of their angiogenic, anti-inflammatory and immunomodulatory properties. However, autologous sources (bone marrow and adipose tissue) requir...
From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy [0.03%]
从信号通路到临床试验：肝硬化治疗中具有多重修复功能的间充质干细胞
Vida Bozorgi,Mahnaz Babaahmadi,Mohammad Salehi et al.
Vida Bozorgi et al.
Liver cirrhosis, a chronic disease distinguished by extensive scarring in the liver, results in liver dysfunction and fatal complications such as portal hypertension and liver cancer. Although early interventions can retard or reverse early...
Somayyeh Rashidi,Sara Aghakhani Chegeni,Golbarg Roozbahani et al.
Somayyeh Rashidi et al.
Ischemic diseases, especially coronary artery diseases and myocardial infarction, are the leading cause of human death in the clinical setting. Unfortunately, most of the available clinical interventions can partially restore the function o...
Chorion tissue- and plasma-derived extracellular vesicles exhibit superior anti-inflammatory and chondroprotective effects [0.03%]
绒毛膜组织和血浆来源的外泌体表现出更优的抗炎和软骨保护作用
Livia K Fecskeova,Jana Matejova,Lucia Slovinska et al.
Livia K Fecskeova et al.
Background: Extracellular vesicles (EVs) are the foundation of modern regenerative medicine using a cell-free approach. While current research mainly explores EVs from biological fluids and cell culture supernatants, tiss...
Stem cell-based therapeutic strategies for down syndrome and Alzheimer's disease [0.03%]
基于干细胞的唐氏综合症和阿尔茨海默病治疗策略
Osama Hamadelseed,Thomas Skutella
Osama Hamadelseed
Background: Down syndrome (DS) and Alzheimer's disease (AD) are two distinct yet interconnected neurological conditions that share overlapping pathological features, including amyloid-beta plaque accumulation, neuroinflam...
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway [0.03%]
人脐带间充质干细胞及其衍生的外泌体通过调节雌激素信号通路缓解地塞米松致肌肉萎缩的作用及机制研究
Na Li,Xiaoqin Liu,Qiong Wang et al.
Na Li et al.
Background: Sarcopenia, a multifactorial syndrome characterized by progressive loss of skeletal muscle mass and strength, combined with impaired physical function, is associated primarily with aging but also driven by chr...
Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway [0.03%]
人脐带间充质干细胞外泌体通过激活Wnt/β-catenain信号通路促进雄激素性脱发毛囊再生
Aiqing Yu,Yujun Zhang,Saifeng Zhong et al.
Aiqing Yu et al.
Background: Exosomes isolated from human umbilical cord mesenchymal stem cells (hUCMSCs) have demonstrated the capacity to alleviate dihydrotestosterone (DHT)-induced disruptions in the hair follicle growth cycle. However...