Mechanisms and clinical progress of adipose-derived stem cells and their derivatives in the treatment of hair loss [0.03%]
脂肪来源干细胞及其衍生物治疗脱发的机制及临床进展
Jiale Zhang,Feng Chen,Yue Hu et al.
Jiale Zhang et al.
The rising prevalence of alopecia poses a significant challenge for both clinicians and researchers. As the global incidence of hair loss continues to increase, research into hair biology and regenerative mechanisms has gained considerable ...
Emodin-Enhanced hUC-MSC extracellular vesicles alleviate acute pancreatitis by targeting inflammation and pyroptosis [0.03%]
大黄素增强的hUC-MSC外泌体通过靶向炎症和焦亡缓解急性胰腺炎
Xiong Liu,Xianwei Huang,Xiaodong Huang et al.
Xiong Liu et al.
Background: Acute pancreatitis (AP) is a complex condition requiring immediate treatment. Both extracellular vesicles derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EVs) and emodin, a naturally occurrin...
Phase II trial of intravenous human dental pulp stem cell therapy for Huntington's disease: a randomized, double-blind, placebo-controlled study [0.03%]
人牙髓干细胞静脉输注治疗亨廷顿病的Ⅱ期临床研究：随机双盲安慰剂对照试验
Joyce Macedo Sanches Fernandes,Eduardo Pagani,Cristiane Valverde Wenceslau et al.
Joyce Macedo Sanches Fernandes et al.
Background: Huntington's disease (HD) is a rare, autosomal dominant neurodegenerative disorder caused by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene. It manifests with...
Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro [0.03%]
棕榈酸通过细胞素/CCL2轴增强MSC体外免疫调节作用
Courteney Tunstead,Laura M Bitterlich,James A Ankrum et al.
Courteney Tunstead et al.
Background: The immunomodulatory function of human mesenchymal stromal cells (MSCs) strongly depends on external factors; such as cytokines and other signalling molecules encountered in the disease microenvironment. An in...
Therapeutic effects of hypoimmunogenic universal human iPSC-derived endothelial cells in a humanized mouse model of peripheral artery disease [0.03%]
低免疫原性通用型人多能干细胞来源的内皮细胞在外周动脉疾病人源化小鼠模型中的治疗作用
Jungju Choi,Nam Gyo Kim,Dasom Kong et al.
Jungju Choi et al.
Background: Peripheral arterial disease (PAD) is a leading cause of limb disability due to ischemia caused by atherosclerotic plaques. Cell-based therapies using endothelial cells (ECs) have shown promise in promoting ang...
Mesenchymal stem cell-derived small extracellular vesicles facilitate repair of acute obstruction-induced colonic anastomosis injury by modulating early-stage inflammation in rats [0.03%]
脂肪源性间充质干细胞外泌体通过调节早期炎症促进急性结肠梗阻后吻合口愈合
Zhiwei Dong,Siran Zhou,Xianfeng Xia et al.
Zhiwei Dong et al.
Background: Anastomotic leakage (AL), a major complication of colonic anastomoses, leads to prolonged hospital stays and increased mortality. Despite various interventions, AL incidence remains high at approximately 8%. M...
Exosomal miR-218 secreted from endothelial progenitor cells mitigates acute lung injury in sepsis mice by inhibiting HMGA1 in alveolar macrophages [0.03%]
内皮祖细胞分泌的外泌体miR-218通过抑制巨噬细胞中的HMGA1蛋白减轻脓毒症小鼠急性肺损伤
Guibin Liang,Menghao Zeng,Qianlu Wang et al.
Guibin Liang et al.
Background and objective: Sepsis-related acute lung injury (S-ALI) had become an important public health issue worldwide. However, the mechanism of S-ALI was still not fully understood. This study aims to investigate the ...
Correction: Adipose-derived stem cells extracellular vesicles enhance diabetic wound healing via CCN2/PI3K/AKT pathway: therapeutic potential and mechanistic insights [0.03%]
纠正：通过CCN2/PI3K/AKT途径增强糖尿病伤口愈合的脂肪源性干细胞外泌体：治疗潜力和机制见解
Yu-Lu Zhou,Shingo Ogura,Hao Ma et al.
Yu-Lu Zhou et al.
Published Erratum
Stem cell research & therapy. 2025 Aug 6;16(1):436. DOI:10.1186/s13287-025-04562-5 2025
Correction: One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study [0.03%]
纠正：同种异体脐带间充质基质细胞一次重复移植治疗1型糖尿病：一项开放性平行对照临床研究
Jing Lu,Shan-Mei Shen,Qing Ling et al.
Jing Lu et al.
Published Erratum
Stem cell research & therapy. 2025 Aug 6;16(1):428. DOI:10.1186/s13287-025-04563-4 2025
Zika virus impairs non-homologous end joining and exacerbates DNA damage in neural progenitors derived from Huntington's disease iPSCs via mutant huntingtin-elicited Ku70/Ku80 complex disruption [0.03%]
寨卡病毒感染通过亨廷顿舞蹈病突变亨廷顿蛋白诱发的Ku70/Ku80复合体破坏，削弱非同源末端连接并使神经前体细胞中基因组DNA损伤加剧
Feng-Lan Chiu,Jian-Jong Liang,Yi-Ling Lin et al.
Feng-Lan Chiu et al.
Background: Zika virus (ZIKV) preferentially infects neural progenitor cells (NPCs) and is associated with NPC depletion in neonates. However, the impacts of ZIKV infection on NPCs in the context of neurodegenerative dise...