Exosomes derived from umbilical cord mesenchymal stem cells alleviate jaw bone marrow mesenchymal stem cells senescence and restore osteogenic differentiation potential [0.03%]
人脐带间充质干细胞源外泌体可改善牙槽骨髓间充质干细胞衰老并恢复其成骨分化能力
Hongkun Li,Nuo Xu,Shuaichen Li et al.
Hongkun Li et al.
Background: The age-related functional decline of bone marrow mesenchymal stem cells significantly impairs bone regeneration capacity. Exosomes derived from umbilical cord mesenchymal stem cells (UCMSCs) have emerged as p...
Unveiling exosomes in combating skin aging: insights into resources, mechanisms and challenges [0.03%]
外泌体抗皮肤衰老研究进展：资源、机制与挑战
Chen Liang,Yi Yi,Jia Li et al.
Chen Liang et al.
Skin ageing is a multifactorial process influenced by both intrinsic (genetic and metabolic) and extrinsic (environmental) factors, leading to noticeable changes such as wrinkles, loss of elasticity, and pigmentation disorders. Recent advan...
Directed and efficient generation of calretinin interneurons from human pluripotent stem cells [0.03%]
人多能干细胞向钙结合蛋白calretinin中间神经元分化的高效诱导及定向分化
Xuewei Du,Renli Qi,Congge Li et al.
Xuewei Du et al.
Background: Schizophrenia, autism, and epilepsy are associated with dysfunctions in cortical GABAergic interneurons. Calretinin-expressing interneurons, the most prominent type, constitute approximately 50% of human corti...
Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions [0.03%]
缺氧条件下乳酸通过调节组蛋白H3K9乳酰化和SnoN表达改善神经发生
Wenhong Xu,Anqi Zhao,Rui Han et al.
Wenhong Xu et al.
Background: Lactate has a beneficial effect on adult neurogenesis and has been identified as a mediator of lactylation of proteins. However, the regulatory role and function of histone lactylation in neurogenesis remain p...
Optimal transplantation strategies for stem cell treatment in premature ovarian failure: a network meta-analysis [0.03%]
干细胞治疗卵巢早衰的最优移植策略网络meta分析研究
Guo Ziwei,Ni Shuang,Wu Di et al.
Guo Ziwei et al.
Background: The incidence of POF has increasingly affected younger individuals in recent years, and stem cell therapy has gradually been incorporated in clinical practice. Given the wide variety of stem cell sources, ther...
Clinicopathologic relevance of EpCAM and CD44 in pancreatic cancer: insights from a meta-analysis [0.03%]
胰腺癌中EpCAM和CD44的临床病理意义：来自meta分析的启示
Bogdan Silviu Ungureanu,Dan Ionut Gheonea,Adina Turcu-Stiolica et al.
Bogdan Silviu Ungureanu et al.
Recent evidence suggests that EpCAM and CD44 could serve as diagnosis or prognosis markers in pancreatic cancer (PC). In this meta-analysis, we evaluated their associations with clinicopathologic features. Specifically, we compared immunohi...
MSC-derived exosomes improve endometrial fibrosis via the lncRNA IGF2R/ miR-143-5p/AQP8 axis [0.03%]
人诱导多能干细胞来源的外泌体通过IGF2R/miR-143-5p/AQP8轴缓解子宫内膜纤维化
Xingyu Huo,Juntong Chen,Maojiao Qian et al.
Xingyu Huo et al.
Background: Endometrial injury (EI) is frequently associated with intrauterine adhesions, endometrial thinning, amenorrhea, and infertility. In recent years, stem cells and their exosomes have been shown to have significa...
Chromatin remodeling and H3K4me3 depletion regulate germline specification from pluripotency [0.03%]
染色质重塑和H3K4me3耗竭调节多能性向生殖细胞的分化
Sheng Wang,Lu Meng,Xiaochen Huang et al.
Sheng Wang et al.
Background: Germ cells are the only cells capable of transmitting heritable genetic material to future generations. Epigenetic mechanisms that regulate germ cell formation are essential for optimizing offspring production...
A systematic review of preclinical studies on therapeutic potential of mesenchymal stem/stromal cells and their secretome in bacterial infections [0.03%]
间充质干细胞及其分泌组治疗细菌感染的潜力的系统性评价研究综述
Leen Ali,Fatimah Shaaban,Elie Salem Sokhn et al.
Leen Ali et al.
Background: Bacterial infections are a globally growing health issue, with an estimated 7.7 million deaths attributed to these infections worldwide. These life-threatening infections, primarily linked to antimicrobial res...
Continuous adipose-derived stem cell therapy from the neonatal stage effectively reduces Duchenne muscular dystrophy symptoms in rats [0.03%]
新生儿阶段的连续脂肪源性干细胞治疗可有效减轻雄激素肌肉营养不良的症状
Yuki Kihara,Masanari Ikeda,Ryo Takagi et al.
Yuki Kihara et al.
Background: The optimal timing for mesenchymal stem cell (MSC) therapy in Duchenne muscular dystrophy (DMD) remains unclear. Methods: N...