Hypertonicity induces mitochondrial extracellular vesicles (MEVs) that activate TNF-α and β-catenin signaling to promote adipocyte dedifferentiation [0.03%]
高渗诱导线粒体外泌体释放，激活TNF-α和β-catenin信号促进脂肪细胞去分化
Guopan Liu,Ying Wang,Yilin Pan et al.
Guopan Liu et al.
Background: Recent studies demonstrated that elevated osmolarity could induce adipocyte dedifferentiation, representing an appealing procedure to generate multipotent stem cells. Here we aim to elucidate the molecular mec...
PD-L1 expression levels in mesenchymal stromal cells predict their therapeutic values for autoimmune hepatitis [0.03%]
间充质基质细胞中PD-L1的表达量可以预测其治疗自身免疫性肝炎的效果
Xilong Bai,Tingwei Chen,Yuqi Li et al.
Xilong Bai et al.
Background: Autoimmune hepatitis is a chronic inflammatory hepatic disorder with no effective treatment. Mesenchymal stromal cells (MSCs) have emerged as a promising treatment owing to their unique advantages. However, th...
HLA-based banking of induced pluripotent stem cells in Saudi Arabia [0.03%]
基于HLA的诱导多能干细胞在沙特阿拉伯的存储银行业务
Maryam Alowaysi,Robert Lehmann,Mohammad Al-Shehri et al.
Maryam Alowaysi et al.
Background: Human iPSCs' derivation and use in clinical studies are transforming medicine. Yet, there is a high cost and long waiting time associated with autologous iPS-based cellular therapy, and the genetic engineering...
O Krasnova,A Kovaleva,A Saveleva et al.
O Krasnova et al.
Background: Three-dimensional (3D) cell culture is widely used in various fields of cell biology. In comparison to conventional two-dimensional (2D) cell culture, 3D cell culture facilitates a more accurate replication of...
Mesenchymal stem cell-based therapy for autoimmune-related fibrotic skin diseases-systemic sclerosis and sclerodermatous graft-versus-host disease [0.03%]
基于间充质干细胞的自身免疫相关性皮肤纤维化疾病-系统硬化病和移植物抗宿主病性硬皮病的治疗
Han Yang,Sousan Cheong,Yunfan He et al.
Han Yang et al.
Background: Systemic sclerosis (SSc) and sclerodermatous graft-versus-host disease (Scl-GVHD)-characterized by similar developmental fibrosis, vascular abnormalities, and innate and adaptive immune response, resulting in ...
The role of c-Jun for beating cardiomycyte formation in prepared embryonic body [0.03%]
c-Jun在定向诱导胚胎体中搏动心肌细胞形成中的作用研究
Lide Su,Guofu Zhang,Lili Jiang et al.
Lide Su et al.
Background: Morbidity and mortality associated with cardiovascular diseases, such as myocardial infarction, stem from the inability of terminally differentiated cardiomyocytes to regenerate, and thus repair the damaged my...
Comments on: "Mesenchymal stem cells transplantation for perianal fistulas: a systematic review and meta-analysis of clinical trials" [0.03%]
评论：间充质干细胞移植治疗肛周瘘管的临床试验系统评价和 meta 分析
Fang Cheng
Fang Cheng
The meta-analysis by Wang et al. (Stem Cell Res Ther 14(1):103, 2023) aims to explore whether mesenchymal stem cells are effective for perianal fistulas. The authors indicated that the difference in cell types, cell sources and cell dosages...
JAK2 as a surface marker for enrichment of human pluripotent stem cells-derived ventricular cardiomyocytes [0.03%]
JAK2作为富集人多能干细胞来源的室壁心肌细胞表面标志物的研究
Lee Chuen Liew,Boon Min Poh,Omer An et al.
Lee Chuen Liew et al.
Background: Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for cardiac disease modelling, drug discovery and regenerative medicine. Despite the advancement in various differentiation pr...
Mesenchymal stem cells overexpressing interleukin-10 prevent allergic airway inflammation [0.03%]
过表达细胞间黏附分子-1的间充质干细胞预防过敏性气道炎症
Peng-Peng Kuang,Xiao-Qing Liu,Chan-Gu Li et al.
Peng-Peng Kuang et al.
Backgrounds: Allergic airway inflammation is prevalent worldwide and imposes a considerable burden on both society and affected individuals. This study aimed to investigate the therapeutic advantages of mesenchymal stem c...
Generation of a bank of clinical-grade, HLA-homozygous iPSC lines with high coverage of the Spanish population [0.03%]
建立临床级别的HLA纯合诱导 pluripotent干细胞系文库，可覆盖大部分西班牙人口主要组织相容性复合体类型
B Kuebler,B Alvarez-Palomo,B Aran et al.
B Kuebler et al.
Background: Induced pluripotent stem cell (iPSC)-derived cell therapies are an interesting new area in the field of regenerative medicine. One of the approaches to decrease the costs of iPSC-derived therapies is the use o...