FKBP prolyl isomerase 4: a potential target for heart failure and cardioprotective effects via leonurine-pretreated mesenchymal stem cell-derived exosomes [0.03%]
FKBP脯氨酰异构酶4：通过益母草素 pretreated间充质干细胞衍生的外泌体的心力衰竭潜在靶点及心保护作用
Zhaoyi Li,De-Chong Zheng,Ruixiang Wang et al.
Zhaoyi Li et al.
The influence of asthmatic inflammation and house dust mite (HDM) exposure on abundance, immune-modulatory potential, and differentiation capacity of the lung-resident mesenchymal stem cells (lrMSCs) [0.03%]
哮喘炎症和粉尘螨(HDM)暴露对肺驻留间充质干细胞的影响：数量、免疫调节能力和分化能力
Alicja Walewska,Marlena Tynecka,Sylwia Ksiezak et al.
Alicja Walewska et al.
Background: Tissue-resident mesenchymal stem cells, also known as mesenchymal stromal cells (MSCs), play a crucial role in maintaining tissue homeostasis and repair. However, their function in chronic inflammatory disease...
Xenotransplantation of Human Umbilical Mesenchymal Stromal Cells Derived from Wharton's Jelly Mitigates Mouse Amyotrophic Lateral Sclerosis [0.03%]
人源脐带华通胶间充质干细胞异种移植改善ALS模型小鼠的运动功能损伤
Chun-Fu Lin,Yu-Hui Chen,Chang-Ching Yeh et al.
Chun-Fu Lin et al.
Background: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of motor neurons in the cerebral cortex, brainstem, and spinal cord, eventually leading to paralysis, res...
AKT signaling upregulates BDNF expression in induced neural stem cells that interact with microglia [0.03%]
Akt信号可以上调诱导神经干细胞中与小胶质细胞相互作用的BDNF表达
Wenjia Wang,Wenqiao Qiu,Pengyu Chen et al.
Wenjia Wang et al.
Background: Brain-derived neurotrophic factor (BDNF) has the capacity to promote neuronal survival that is crucial to neurological recovery after closed head injury (CHI). We previously reported that intracerebral-transpl...
Programmed cell death regulates hematopoietic cell homeostasis under radiation conditions [0.03%]
程序性细胞死亡调控辐射条件下的造血细胞稳态
Manling Shu,Jinfu Zhang,Yuhong Peng et al.
Manling Shu et al.
Background: It is well-known that hematopoietic cells are sensitive to irradiation exposure. Apoptosis, necroptosis, pyroptosis and ferroptosis might contribute to irradiation-induced hematopoietic injury. However, it is ...
The therapeutic potential of mesenchymal stem cells in intestinal diseases: from mechanisms to clinical translation [0.03%]
间充质干细胞在肠病治疗中的潜力：从中枢机制到临床转化
Jia-Zhi Yang,Li-Yan He,Xian-Zhou Lu
Jia-Zhi Yang
Current therapeutic interventions for intestinal pathologies, including anti-inflammatory agents, immunosuppressants, and surgical procedures, frequently incur substantial adverse effects, elevated recurrence rates, and suboptimal tissue re...
Therapeutic impact of human trophoblast stem cells in peritoneal and pneumonia-induced sepsis in mice [0.03%]
人胎盘干细胞对小鼠腹腔感染和肺炎所致脓毒症的治疗作用
Narae Hwang,Gu Li,Ekaterina Murzin et al.
Narae Hwang et al.
Background: Sepsis is a complex and life-threatening disease process related to a systemic response to severe infection. Due to the challenges of treating patients with sepsis, new therapies are being investigated, includ...
CD317 stabilizes TNFR1 and confers the anti-inflammatory functions of MSCs via NF-κB/TSG6 pathway [0.03%]
CD317通过NF-κB/TSG6信号通路稳定TNFR1并赋予间充质干细胞的抗炎功能
Si Chen,Lan Yao,Xin Wen et al.
Si Chen et al.
Background: Although both pre-clinical and clinical studies show promising outcomes, resulting in rapid growth of clinical trials of MSC-based therapies in recent years, the heterogeneity and therapeutic inconsistency of ...
Enhanced neuromorphogenesis of neural stem cells via the optimization of physical stimulus-responsive signaling pathways [0.03%]
通过优化物理刺激反应信号通路增强神经干细胞的神经形态发生
Youyi Tai,Natasha Brinkley,Lu Jin et al.
Youyi Tai et al.
Background: Neural stem cells hold significant promise for developing in vitro nerve models due to their capacity to differentiate into diverse neural cell types. While traditional biochemical approaches often restrict di...
Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury [0.03%]
辐射介导的树突状细胞活化加剧骨髓间充质干细胞炎症反应并抑制下颌骨再生医学修复中的辐照损伤诱导性破骨形成
Mengting Zheng,Heng Chen,Zhonglong Liu et al.
Mengting Zheng et al.
Background: Radiation-induced jaw injury is one of the most severe complications after radiotherapy for head and neck cancer, which can disrupt patients' health and quality of life. Although the direct target of inflammat...