Novel pharmaco-exosomal immunotherapy for united airway diseases: PLGA-encapsulated, mesenchymal stem cell-derived exosomes with PPAR-γ agonist for allergic rhinitis and asthma [0.03%]
用于联合性呼吸道疾病的新型药物外泌体免疫治疗：PLGA包封的间充质干细胞衍生外泌体与PPAR-γ激动剂对过敏性鼻炎和哮喘的作用
Khawar Ali Shahzad,Zhao Wang,Boyu Cai et al.
Khawar Ali Shahzad et al.
Background: The united airway diseases (UADs), exemplified by allergic rhinitis and asthma, cause significant morbidity. Although conventional pharmacotherapy provides symptomatic relief, recent evidence has indicated tha...
Cardiomyocyte regeneration therapy and its effect on LVEF and scar size- a systematic review and meta-analysis [0.03%]
心肌细胞再生疗法及其对左心室射血分数和瘢痕大小的影响-系统评价和meta分析
Mahnoor Mahnoor,Syed Irtaza Hassan,Muhammad Bakhtiar et al.
Mahnoor Mahnoor et al.
Background: Myocardial infarction (MI) results in loss of cardiomyocytes leading to heart failure. Despite advancements in pharmacotherapy and interventions such as revascularization, ischemic heart failure remains a chal...
BACH1 recruits STAT3 to enhance leukemia inhibitory factor receptor activity and augments the self-renewal capacity of mouse embryonic stem cells [0.03%]
BACH1通过募集STAT3增强白细胞介素6信号转导抑制因子受体的活性并增加小鼠胚胎干细胞自我更新的能力
Jinghua Ma,Siyu Ma,Cong Niu et al.
Jinghua Ma et al.
Background: Genomic studies have linked single nucleotide variants in the enhancer region of the leukemia inhibitory factor receptor (Lifr) gene to chromatin accessibility and the regulation of self-renewal in mouse embry...
Platelet-rich plasma (PRP) and the future of male fertility: a path forward for personalized and regenerative therapies [0.03%]
富血小板血浆(PRP)与男性生育的未来：个性化和再生疗法的发展方向
Seyyed Amir Moradian,Zahra Amirkhani,Mansoureh Movahedin et al.
Seyyed Amir Moradian et al.
Background: Platelet-rich plasma (PRP) and its subtype, plasma rich in growth factors (PRGF), are autologous blood-derived products that have garnered increasing attention as personalized therapeutic tools in the field of...
3D TGF-β1-expressing mesenchymal stem cells enhance wound healing in a diabetic mouse model [0.03%]
表达TGF-β1的间充质干细胞促进糖尿病小鼠模型伤口愈合
Dong-Sik Chae,Sang Joon An,Seongho Han et al.
Dong-Sik Chae et al.
Background: Human mesenchymal stem cells (MSCs) are a promising stem cell source; however, their therapeutic efficacy in chronic wound healing remains limited. This study evaluates the therapeutic potential of transformin...
Platelet-rich plasma enhances local homing of umbilical cord-derived mesenchymal stem cells to articular cartilage by increasing the quantity and activation of integrin ꞵ1 [0.03%]
富血小板血浆通过增加整合素β1的数量和活化来增强脐带间充质干细胞向关节软骨的归巢作用
Min Ji Lee,Soo Hyun Kim,Sue Shin et al.
Min Ji Lee et al.
Background: Enhancing mesenchymal stem cells (MSCs) engraftment at the degenerative cartilage is important to increase the therapeutic effect of cartilage regeneration. Platelet-rich plasma (PRP) is known to have anti-inf...
The role of ASS1 in mouse embryonic stem cell differentiation into mesendoderm lineages [0.03%]
ASS1在小鼠胚胎干细胞向中内胚层分化中的作用研究
Guodong Zhao,Qiaoqiao Meng,Shuo Cao et al.
Guodong Zhao et al.
Background: Argininosuccinate synthase (ASS1) is a pivotal enzyme involved in the urea cycle, playing a crucial role in aspartate catabolism, arginine and nitric oxide biosynthesis. These biological processes are crucial ...
The interrelationship between interleukin-17 A and the immunomodulation of mesenchymal stromal cells [0.03%]
间充质基质细胞免疫调节与白介素-17A的相互作用关系研究进展
Tengxiao Ma,Haoxinai Wang,Bo Hu et al.
Tengxiao Ma et al.
The interaction between interleukin-17 A (IL-17 A) and mesenchymal stromal cells (MSCs), and its role in immune regulation, is a new research field with broad application potential. This review aims to elucidate the complex relationship bet...
Ontogenetic stage and type of donor cells shape extracellular vesicles' therapeutic potential for osteoarthritis [0.03%]
发育阶段和供体细胞类型塑造外泌体治疗骨关节炎的潜力
K Tarasova,M B Arteaga,A Kidtiwong et al.
K Tarasova et al.
Background: Osteoarthritis (OA) remains an intractable condition due to the limited regenerative capacity of adult cartilage. Extracellular vesicles (EVs) have emerged as promising therapeutics, yet the optimal donor cell...
Engineering modification of human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorates polycystic ovary syndrome by enhancing the ovarian environment and regulating follicular development [0.03%]
工程化改造人脐带间充质干细胞来源的小细胞外囊泡通过改善卵巢微环境及调节卵泡发育缓解多囊卵巢综合征
Kang Ding,Xinyu Wang,Wei Liu et al.
Kang Ding et al.
Background: Polycystic Ovary Syndrome (PCOS), is a complex endocrine disorder affecting 6-21% of reproductive-aged women, characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology. Current ...