Method development and validation for simultaneous analysis of four bile acids as CYP3A drug-drug interaction biomarkers [0.03%]
四种胆酸作为药物相互作用生物标志物的CYP3A药物相互作用生物标记物的同时分析的方法开发与验证
Zhiyin Xun,Lin Zhang,Ryan McGee et al.
Zhiyin Xun et al.
Aim: To develop and validate a robust LC - MS/MS method for the simultaneous quantification of endogenous deoxycholic acid (DCA), 1β-hydroxydeoxycholic acid (1β-OH-DCA), 1β-hydroxydeoxycholic acid glycine conjugate (1...
Nucleic acid nanorobot assay for accurate and simplified ASO quantification in mouse plasma [0.03%]
核酸纳米机器人测定法简化和准确量化小鼠血浆中反义寡核苷酸浓度
Åsa Sandelius,Cheryl Arrowsmith,Neil Henderson et al.
Åsa Sandelius et al.
Aim: Pharmacokinetic (PK) characterization and accurate quantification is critical for drug development. The broad potential for antisense oligonucleotide (ASO) drugs to target previously undruggable pathways has resulted...
Comparison of assay performance between qPCR and a nanoplate-based digital PCR in bioanalysis of biodistribution studies [0.03%]
qPCR与基于纳米板的数字PCR在生物分布研究生物分析中的性能比较
Yanchun Li,Hsing-Yin Liu,Kate Herr et al.
Yanchun Li et al.
Background: Cell and Gene Therapy (CGT) utilizes a nucleic acid core, which makes quantitative PCR (qPCR) a critical tool for establishing pharmacokinetics profiles supporting preclinical and clinical studies of CGT progr...
Improving sensitivity and drug tolerance of assays for neutralizing anti-drug antibodies to semaglutide and native GLP-1 [0.03%]
提高对司美格鲁肽和人GLP-1的中和性抗药物抗体检测方法的灵敏度和耐药性
Nicoline Videbæk,Louise Jørgensen,Carina de Lemos Rieper et al.
Nicoline Videbæk et al.
Aim: The purpose of this work was to optimize the sensitivity and the drug tolerance of two cell-based assays for the detection of neutralizing antibodies (nAbs) to semaglutide (a GLP-1 analogue) and to endogenous GLP-1. ...
Rethinking validation paradigms for qPCR and dPCR assays in bioanalysis [0.03%]
重组验证体系进行qPCR和dPCR在生物分析中的应用
Amanda L Hays
Amanda L Hays
Quantification of keratan sulfate in biofluids by validated HPCE-LIF: application to Morquio syndrome [0.03%]
一种经验证的高效毛细管电泳-激光诱导荧光法定量生物液体中硫酸角质素：摩QUI阿氏病的应用
Fabio Galeotti,Lucia Zampini,Francesca Maccari et al.
Fabio Galeotti et al.
Background: Keratan sulfate (KS) is altered in several pathological conditions. We report the capillary electrophoresis-laser induced fluorescence separation and validation of KS-derived disaccharides Galβ(1-4)GlcNAc(6S)...
Sara Haile,Ting Jiang,Connor Kenney et al.
Sara Haile et al.
Abhishek Jain,Alejandro Rodriguez,Amanda Smythers et al.
Abhishek Jain et al.
Development of production methodologies for scFv-Fc conjugated critical reagents to support CAR-T clinical programs [0.03%]
用于支持CAR-T临床项目的scFv-Fc偶联关键试剂的生产方法开发
Ellen O&#x;Connor,Eric Lachacz,Jared Delmar et al.
Ellen O&#x;Connor et al.
Introduction: Routine conjugation protocols are typically used by bioanalytical laboratories for production of their assay critical reagents. Novel molecules can pose unique challenges to the production of high-quality co...
When is a sample a urine sample? Markers for urine sample authenticity assessment in sports drug testing [0.03%]
同尿样有何区别：运动药物检测中认定尿样的标志物
T Piper,H Geyer,F Huelsemann et al.
T Piper et al.
Human routine doping controls rely to a considerable extent on urine samples, and test methods have been optimized for decades to allow for comprehensive analyses with adequate analytical sensitivities. However, attempts of sample manipulat...