Recent advances and clinical applications for the rapid detection of pathogenic bacteria in biological samples [0.03%]
Jinzhi Liu,Zhuolin Miao,Yueling Yan et al.
Jinzhi Liu et al.
Infectious diseases have a wide range of significant characteristics with complex clinical manifestations. The incidence rate and mortality rate remain high, seriously endangering human health. Therefore, rapid identification and sensitive ...
Development and validation of an LC-MS/MS method for the quantification of novel therapeutic TT-478, a selective adenosine receptor 2B antagonist, for a phase I/II clinical trial [0.03%]
Daniel Whitaker,Laura Francis,Sami Karaborni et al.
Daniel Whitaker et al.
Background: TT-478 is a novel adenosine receptor 2B antagonist, administered orally as a prodrug (TT-702) for the treatment of advanced metastatic prostate cancer in a Phase I/II clinical trial setting. A liquid chromatog...
Clinical Trial
Bioanalysis. 2025 Sep;17(17):1105-1112. DOI:10.1080/17576180.2025.2554564 2025
You-Rim Lee,Jae Guk Kim,Soo Joo Lee et al.
You-Rim Lee et al.
Aim: Ischemic stroke (IS) occurs when a clot obstructs cerebral blood flow, leading to potentially irreversible damage. Metabolites, as the end products of cellular metabolism, can reflect pathological changes in the body...
Recent advances in the identification and quantification of xylazine and medetomidine in biological specimens [0.03%]
生物样品中昔拉嗪和美托咪啶的识别与定量的最新进展
Bridgit O Crews
Bridgit O Crews
Xylazine is a veterinary sedative that is frequently detected in the illicit drug supply, often found mixed with illicitly manufactured fentanyl (IMF). It has been detected in the blood of overdose victims and patients who use illicit drugs...
Performance properties of filter-paper used in blood spot collection devices for quantitation of phenylalanine [0.03%]
滤纸在血斑收集装置中定量苯丙氨酸的性能属性
Annabel Rodham,Christopher von Ruhland,Rachel Carling et al.
Annabel Rodham et al.
Aims: Accurate and precise measurement of dried blood spot (DBS) phenylalanine (Phe) is vital for managing phenylketonuria (PKU). Standard DBS collection devices use grade-226 filter-paper, while the CapitainerB quantitat...
CRISPR-based platforms for detecting tumor-associated genetic materials in clinical samples [0.03%]
基于CRISPR的检测临床样本中肿瘤相关遗传材料的技术平台
Xiaoqing Chen,Qiaoyuan Ye,Qingle Liang et al.
Xiaoqing Chen et al.
Tumor-associated genetic markers are useful for early cancer screening, diagnosis, and treatment monitoring. However, traditional detection methods are complex in operation procedures, time-consuming, and the equipment costs are expensive. ...
Patient centric blood sampling and analysis for diagnostics and laboratory medicine [0.03%]
以患者为中心的采血及检测和检验医学中的分析方法
Neil Spooner,Daniel Baker,Rachel S Carling et al.
Neil Spooner et al.
Blood sampling and diagnostic laboratory analysis are important aspects of our healthcare systems and patient management. However, the process by which the majority of blood specimens are currently collected, venipuncture, does not put the ...
Development of a UPLC-MS/MS method for simultaneous quantification of 7 bile acids in feces: application to UC mice [0.03%]
一种粪便中7种胆酸同时定量的UPLC-MS/MS方法的发展及在UC型小鼠中的应用
Junyan Cao,Yanchun Chang,Yonghui Li et al.
Junyan Cao et al.
Aim: This study aimed to establish a method for the simultaneous quantification of 7 bile acid components in mouse feces and to apply this method to investigate the variations in bile acid profiles among control, DSS, and...
Sara Haile,Ting Jiang,Connor Kenney et al.
Sara Haile et al.
The acute oral toxicity and pharmacokinetic determination of a novel chloroquinoline hybrid molecule by LC-MS/MS [0.03%]
LC-MS/MS测定新型氯喹杂合分子的急性口服毒性及药代动力学研究
Monique Labuschagne,Makhotso Lekhooa,Thrineshen Moodley et al.
Monique Labuschagne et al.
Background: CB-1 is a novel compound evaluated in Sprague Dawley rats to assess its acute oral safety and pharmacokinetic disposition. Objectives: ...