Inhibition of PGC1β-dependent mitochondrial biogenesis enhances EGFR-targeted therapy in lung cancer [0.03%]
PGC1β依赖的线粒体生物合成抑制可增强肺癌EGFR靶向治疗
Zhen Chen,Dongsheng Wang,Songqing Fan et al.
Zhen Chen et al.
Third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs), including osimertinib, show robust clinical efficacy in EGFR-mutant (EGFRm) non-small cell lung cancer (NSCLC), yet acquired resistance remains inevitable. Here, we demonstrate t...
Author Correction: Domain-substituted IGF2 tag modulates targeting of lentiviral gene therapy for Hunter syndrome [0.03%]
作者更正：IGF2标签域替代调控亨特综合征溶酶体基因疗法靶向作用
Fabio Catalano,Dejan Stevic,Giacomo Zundo et al.
Fabio Catalano et al.
Published Erratum
EMBO molecular medicine. 2026 Jul 29. DOI:10.1038/s44321-026-00492-8 2026
RADX protects against intestinal inflammation by restraining IFI16-mediated innate immunity [0.03%]
RADX通过限制IFI16介导的先天免疫反应来预防肠道炎症
Huifang Xian,Wanming Huang,Zhanghua Chen et al.
Huifang Xian et al.
Genomic instability is increased in patients with inflammatory bowel disease (IBD), yet whether it contributes directly to disease pathogenesis remains unclear. Here, we identify RADX, a structural antagonist to RAD51 and a key regulator of...
Abnormal ClC-3/TMEM9-mediated endosomal ion transport in CLCN3-associated neurodevelopmental disease [0.03%]
CLCN3相关神经发育障碍中异常的ClC-3/TMEM9介导的内体离子转运
Maya M Polovitskaya,Tinatin Tkemaladze,Lotte Jensen et al.
Maya M Polovitskaya et al.
Endolysosomal abnormalities are particularly detrimental to the nervous system and have been implicated in neuropsychiatric disorders. Key regulators of the lysosomal and endosomal luminal ion homeostasis are CLC chloride/proton exchangers....
DeepPlaque: a scalable multimodal platform for Aβ pathology and cell analysis in Alzheimer's disease [0.03%]
DeepPlaque：一种针对阿尔茨海默病中淀粉样蛋白病理和细胞分析的可扩展多模态平台
Hiu Yi Wong,Cheng Jin,Sze Long Yuen et al.
Hiu Yi Wong et al.
Histological analysis is essential for understanding disease pathology and the microenvironment, particularly in Alzheimer's disease (AD), characterized by beta-amyloid (Aβ) plaques that exist as diffuse, fibrillar, and core species, with ...
β-hydroxybutyrate restores social deficits by suppressing HDAC9 in the ACC of Shank3B-deficient mice [0.03%]
β-羟丁酸通过抑制SHANK3B基因缺陷小鼠ACC区HDAC9恢复社交缺损
Erling Hu,Jialong Li,Chuchu Qi et al.
Erling Hu et al.
Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using...
Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy [0.03%]
黑色素瘤细胞选择性地翻译mRNA以适应BRAF/MEK联合疗法的耐药机制
Lucilla Fabbri,Lucie Lagadec,Eva Guérin et al.
Lucilla Fabbri et al.
During their inevitable evolution towards acquired resistance to anti-cancer targeted therapies, cancer cells adopt distinct gene expression profiles that allow them to transiently adapt to and tolerate the treatment. Cancer cells surviving...
Author Correction: A therapeutic regimen using neoantigen-specific TCR-T cells for HLA-A*2402-positive solid tumors [0.03%]
作者更正：使用新型抗原特异性TCR-T细胞的治疗方案用于HLA-A*2402阳性实体瘤
Yuncheng Bei,Ying Huang,Nandie Wu et al.
Yuncheng Bei et al.
Published Erratum
EMBO molecular medicine. 2026 Jul 16. DOI:10.1038/s44321-026-00487-5 2026
Predictive value of plasma p-tau217 for Alzheimer's dementia compared to other blood-based biomarkers [0.03%]
血浆p-tau217预测阿尔茨海默病痴呆的价值与其他血液生物标志物的比较
Kira Trares,Deniz Duman,Léon Beyer et al.
Kira Trares et al.
Phosphorylated-tau (p-tau217) is a promising blood-based biomarker for Alzheimer's dementia (AD) in clinical settings. However, research from prospective cohort studies is sparse. We measured plasma p-tau217 levels in baseline blood samples...
RXRα suppression drives hepatic metabolic and immune dysfunction in sepsis [0.03%]
RXRα抑制驱动了脓毒症肝代谢和免疫功能障碍
Matyas Jelinek,Jolien Vandewalle,Marah Heyerick et al.
Matyas Jelinek et al.
Sepsis is a life-threatening condition in which a dysregulated host response to infection leads to organ dysfunction and metabolic and immune failure. We identify hepatocyte retinoid X receptor α (RXRα) as a key integrator of host resilie...