Zhaoyu Jiang,Yuxuan Wu,Yuqing Guo et al.
Zhaoyu Jiang et al.
Accurate circulating tumor DNA (ctDNA) detection is limited by high sequencing errors. To address this, we developed Methyltransferase-Assisted Single Duplex sequencing (MASD-seq), which physically links Watson and Crick strands to enable e...
PRMT5-mediated intron retention triggers innate and adaptive immunity against cancer [0.03%]
PRMT5介导的剪接本体维持触发针对癌症的先天性和适应性免疫反应
Wiktoria Blaszczak,Wojciech Barczak,Chuyue Zhang et al.
Wiktoria Blaszczak et al.
PRMT5 is expressed at high levels in many cancers, where it regulates diverse cellular pathways that contribute to oncogenesis. Here, we have defined a new role for PRMT5 in regulating and coordinating the interplay between the innate and a...
Blocking AGEs reduces airway epithelial viral susceptibility in diabetes-exacerbated COPD [0.03%]
阻断糖尿病加重慢性阻塞性肺病时的晚期糖基化终产物可降低气道上皮病毒易感性
Zhenfeng Chen,Yueying Qin,Bingqi Lin et al.
Zhenfeng Chen et al.
Although diabetic complications are well-established in multiple organs, their impact on the respiratory system remains unclear. Clinical evidence indicates accelerated chronic obstructive pulmonary disease (COPD) progression in individuals...
When sugar takes your breath away: how diabetes accelerates COPD progression [0.03%]
糖尿病会夺走你的呼吸吗？糖尿病如何加速慢阻肺的进展
Annabelle Elisabeth Kruf,Kathrin Maedler
Annabelle Elisabeth Kruf
Diabetes is much more than high blood sugar. In this issue of EMBO metabolism, Chen et al (REF Chen et al 2026) show that hyperglycemia impairs the lung’s antiviral defense while driving excessive inflammation through the accumulation of h...
Xiaobo Yu,Jing Yang,Bomiao Yu et al.
Xiaobo Yu et al.
Population proteomics is emerging as a new framework for equitable precision medicine. By studying protein variation across populations, this field bridges population genomics and conventional proteomics to capture the functional molecular ...
Disease-driven post-transcriptional alterations and alternative splicing in podocytes in focal segmental glomerulosclerosis [0.03%]
特发性局灶节段性肾小球硬化podocyte中的疾病驱动的转录后变化和可变剪接
Francescapaola Mattias,Olga Tsoy,Anna Iervolino et al.
Francescapaola Mattias et al.
Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and progression to end-stage renal disease, yet its molecular pathogenesis remains still incompletely defined. While transcriptional alterations in podocytes h...
Targeting CD44 reverses sphingomyelin-induced oligodendrocyte maturation arrest in acid sphingomyelinase deficiency [0.03%]
靶向CD44可逆转酸性鞘氨醇单胞菌缺乏症引起的髓鞘形成细胞成熟停滞
Marta Guerrero-Valero,Elena Melgarejo,Miguel A Marchena et al.
Marta Guerrero-Valero et al.
Loss-of-function mutations in the smpd1 gene cause acid sphingomyelinase deficiency (ASMD). Early neurodegeneration and lethality characterize its infantile neurovisceral form (type A). While neuronal dysfunction was traditionally considere...
Excess folate elevates formaldehyde genotoxicity in cell lines but not in mice or humans [0.03%]
细胞系中叶酸过量可增强甲醛的致突变性但并未在小鼠或人中发现该现象
Christopher Mellor,Brandon T James,Saeideh Azad et al.
Christopher Mellor et al.
Folate metabolites are chemically unstable: spontaneous decomposition releases formaldehyde, a genotoxin in blood stem cells and a human carcinogen. Despite this, folic acid consumption frequently exceeds the Recommended Dietary Allowance a...
The telomeric DNA damage response as a therapeutic target in idiopathic pulmonary fibrosis [0.03%]
端粒DNA损伤反应作为特发性肺纤维化治疗靶点的研究
Francesca Rossiello,Giada Cicio,Sara Sepe et al.
Francesca Rossiello et al.
Telomere dysfunction and the telomeric DNA damage response (tDDR) activation correlate with aging and age-related diseases, including idiopathic pulmonary fibrosis (IPF). However, a causal role for tDDR in IPF pathogenesis has not been dete...
Dengue virus envelope epitope-specific antibodies are associated with protection from severe dengue [0.03%]
登革病毒包膜表位特异性抗体与登革热重症保护有关
Sokchea Lay,Heidi Auerswald,Sievleang Heng et al.
Sokchea Lay et al.
Our understanding of a protective humoral immune response to dengue virus (DENV) remains limited. The envelope (E) protein is the main antibody (Ab) target. While anti-fusion loop (FL) epitope monoclonal Abs (mAbs) can induce antibody depen...