A viral glycoprotein targets IgG+ memory B cells to mediate humoral immune evasion [0.03%]
一种病毒糖蛋白通过靶向IgG+记忆B细胞介导体液免疫逃逸
Precious Cramer,Stefan F H Neys,Manuela Fiedler et al.
Precious Cramer et al.
Virus infections elicit long-term IgG antibody and memory responses. Human cytomegalovirus (HCMV) is widespread in humans and disseminates despite the presence of virus-specific antibodies. Here, we report that the HCMV Fcγ-binding glycopr...
Correction to: De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma [0.03%]
NF2缺陷型间皮瘤中从头嘧啶合成是脱靶代谢脆弱性——对《 NF2缺乏症引起的间皮瘤中从头嘧啶合成是一种非目标代谢脆弱性》的更正
Duo Xu,Yanyun Gao,Shengchen Liu et al.
Duo Xu et al.
Published Erratum
EMBO molecular medicine. 2026 Jan 16. DOI:10.1038/s44321-025-00366-5 2026
NOTCH1 intracellular domain stabilization by MDM2 plays a major role in NSCLC response to platinum [0.03%]
NOTCH1胞内段由MDM2稳定在NSCLC铂敏感性中起主要作用
Sara Bernardo,Lisa Brunet,Quentin Dominique Thomas et al.
Sara Bernardo et al.
Despite major advances in the clinical management of non-small cell lung carcinoma (NSCLC), most patients treated with first-line platinum-based chemotherapy combined with immune checkpoint inhibitors will relapse, which constitutes an unme...
Sarcomeric remodelling in human heart failure unraveled by single molecule long read sequencing [0.03%]
单分子长读测序揭示的人心力衰竭肌节重构
Jan Haas,Sarah Schudy,Benedikt Rauscher et al.
Jan Haas et al.
Dysregulation of alternative splicing - mediated by factors such as RBM20 or SLM2 - can affect proper gene isoform control, disrupting gene isoform homeostasis and underpins severe cardiomyopathy in both animal models and patients. Although...
Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins [0.03%]
一种基于细胞外囊泡的用于多种细胞外蛋白降解的技术平台
Bide Tong,Xiaoguang Zhang,Dingchao Zhu et al.
Bide Tong et al.
Targeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems. Extracellular vesicles (EVs) have shown potential to act as next-generation TP...
Allison T Woods,Abner A Murray,Benjamin G Vincent et al.
Allison T Woods et al.
Metastatic malignant pleural effusion (MPE) represents advanced-stage cancer and is defined by the establishment of metastatic tumor foci within the pleural space. It is most commonly associated with high degrees of morbidity and mortality....
TKI-mediated inhibition of NLRP1 inflammasome restores erythropoiesis in DBA syndrome [0.03%]
酪氨酸激酶抑制对DBA综合征NLPR1炎性小体的抑制可恢复红细胞生成
Juan M Lozano-Gil,Lola Rodríguez-Ruiz,Manuel Palacios et al.
Juan M Lozano-Gil et al.
Diamond-Blackfan anemia syndrome (DBAS) is marked by defective erythropoiesis caused by impaired ribosome biogenesis and aberrant signaling. Here, we investigate how ribosomal stress-induced activation of the NLRP1 inflammasome affects eryt...
Functional rescue and AI analysis of a human inactivating GPCR mutation using a small molecule [0.03%]
通过小分子对人类失活G蛋白偶联受体突变进行功能补救及人工智能分析
Debajyoti Das,Amanda Wyatt,Sarath Sivaprasad et al.
Debajyoti Das et al.
G protein-coupled receptors (GPCRs) carry out the majority of cellular transmembrane signaling. Many pathologies have underlying GPCR mutations, most of which cause misfolding and GPCR cell surface trafficking failure. Large libraries of ex...
The Goldilocks paradox: when partial oncoprotein inhibition fuels metastasis in Ewing sarcoma [0.03%]
金发姑娘悖论——部分抑制oncoprotein可促进尤文肉瘤的转移
Marie Castets,Adrien Bertrand-Chapel,Jean-Yves Blay
Marie Castets
A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data [0.03%]
由INS突变引起的糖尿病新形式：由基因型、干细胞和人群数据定义
Yue Tong,Marianne Becker,Ulrike Schierloh et al.
Yue Tong et al.
The INS c.16 C > T (insulin p.Arg6Cys, R6C) variant was reported to cause autosomal dominant monogenic diabetes, yet its pathogenicity has been questioned. R6C preproinsulin exhibits impaired translocation into the endoplasmic reticulum (ER...