Artificial intelligence in ovarian pathophysiology and management: a systematic review and meta-analysis [0.03%]
人工智能在卵巢病理生理和管理中的应用：系统回顾和荟萃分析
Hang Yu,Lifan Peng
Hang Yu
Background: The integration of artificial intelligence (AI) into reproductive medicine and gynecologic oncology has driven transformative advances in the diagnosis, prognosis, and management of ovarian conditions, includi...
Abnormal adnexal uptake in 68Ga-FAPI PET/CT: from physiological variants to malignant characterization [0.03%]
68 Ga-FAPI PET/CT附件异常摄取：从生理变异到恶性特征的鉴别
Qixin Wang,Rui Sun,Canran Xiao et al.
Qixin Wang et al.
Background: The adnexal region in females presents complex imaging due to the menstrual cycle. Accurate diagnosis is crucial for effective tumor treatment. This study aims to assess the clinical utility of abnormal adnexa...
Vitamin E alleviates energy stress-induced injury in yak granulosa cells by blocking the AMPK/mTOR-mitophagy-ferroptosis axis [0.03%]
维生素E通过阻断AMPK/mTOR-线粒体自噬-铁死亡轴缓解能量压力诱导的藏羚羊颗粒细胞损伤
Hecheng Zhang,Guorong Ye,Linjiao Bai et al.
Hecheng Zhang et al.
Background: Energy stress-induced dysfunction of granulosa cells (GCs) is a major etiological factor in diminished female reproductive performance. Although vitamin E affords cytoprotection to GCs, its specific mechanisms...
Two-staged CT-based radiomics model in characterising early-stage ovarian carcinoma and benign ovarian masses [0.03%]
基于CT的放射组学模型在早期卵巢癌和良性卵巢肿物特征分析中的应用
Jiarui Zhang,Rahul Singh,Esther Man Fung Wong et al.
Jiarui Zhang et al.
Background: Characterisation of CT detected ovarian masses is challenging with overlapping imaging features, unreliable biomarker or clinical presentation. We proposed a two-staged CT-based radiomics model to identify ear...
YAP inactivation-mediated autophagy inhibition contributes to cisplatin resistance in ovarian cancer cells [0.03%]
YAP失活介导的自噬抑制对卵巢癌细胞顺铂耐药性的影响研究
Ngoc Thang Nguyen,Meng-Ru Hsieh,Hieu Dac Hanh Nguyen et al.
Ngoc Thang Nguyen et al.
Background: Cisplatin resistance remains a critical barrier in the treatment of high-grade serous ovarian cancer (HGSOC). Although Hippo-YAP signaling regulates cancer progression, its contribution to cisplatin resistance...
Identification of two novel PATL2 variants and transcriptome sequencing reveals their role in oocyte maturation [0.03%]
识别出两个新的PATL2变异体并通过转录组测序揭示其在卵母细胞成熟中的作用
Li Yu,Lin Wang,Baishen Pan et al.
Li Yu et al.
Purpose: Oocyte maturation defect (OMD) is a rare cause of female infertility characterized by the persistent arrest of oocytes at immature stages. While biallelic PATL2 variants have been associated with OMD, the underly...
A potential mutation-defined POLE/MMR/TP53 group classifications to stratify BRCA wild type epithelial ovarian cancer [0.03%]
潜在的以POLE/MMR/TP53基因为标志的BRCA野生型上皮性卵巢癌分类法
Yi-Ting Chen,Po-Han Lin,Yi-Jou Tai et al.
Yi-Ting Chen et al.
Background: TCGA molecular classification has prognostic value in endometrial cancer, but its application in epithelial ovarian cancer is not clear. Metho...
Kisspeptin exacerbates androgen-induced follicular dysplasia by promoting Drp1 phosphorylation imbalance and mitochondrial excessive fission in granulosa cells of polycystic ovary syndrome [0.03%]
吻肽通过促进多囊卵巢综合征卵泡膜细胞Drp1磷酸化失衡和线粒体过度分裂加重雄激素诱导的卵泡发育不良
Xiaoyan Li,Ying He,Yiran Wang et al.
Xiaoyan Li et al.
Immediate protective effect of rUCMSC-EVs on ovarian function in a cyclophosphamide -induced premature ovarian insufficiency rats: counteracting granulosa cell apoptosis [0.03%]
人脐带间充质干细胞外泌体通过对抗颗粒细胞凋亡即时保护环磷酰胺致卵巢早衰大鼠卵巢功能
Zelan Yang,Cheng Zou,Yufei Deng et al.
Zelan Yang et al.
Backgrounds: Premature ovarian insufficiency (POI), which is defined as the loss of ovarian activity before the age of 40 leading to amenorrhea and infertility, is often induced in female patients treated with alkylating ...
Knocking down CLDN7 enhanced the effect of cisplatin in OC cells by regulating mitophagy [0.03%]
通过调节线粒体自噬增强CLDN7敲低的卵巢癌细胞的顺铂效应
Xiushuang Zheng,Bingbing Hu,Qing Xu et al.
Xiushuang Zheng et al.
Background: Ovarian cancer (OC) remains a leading cause of female mortality due to its complex pathological progression and the lack of early screening methods. The cisplatin chemotherapy resistance is a stumbling block i...