Anti-androgen therapy in polyendocrine metabolic ovary syndrome (PMOS, formerly PCOS): efficacy, safety, and phenotype-oriented clinical decision-making [0.03%]
抗雄激素治疗多内分泌代谢卵巢综合征（PMOS，即PCOS）的疗效、安全性及表型导向临床决策
Hongfa Peng,Jingjing Jiang,Zhu Wang et al.
Hongfa Peng et al.
Polyendocrine metabolic ovarian syndrome (PMOS, formerly polycystic ovary syndrome [PCOS]), hereinafter referred to as PMOS/PCOS, is the most prevalent endocrine metabolic disorder among women of reproductive age. It is characterized by a s...
Cyclophosphamide-induced animal models of ovarian dysfunction: from molecular mechanisms and modeling strategies to validation criteria [0.03%]
环磷酰胺诱导的卵巢功能障碍动物模型：从分子机制和建模策略到验证标准
Yanxi Wang,Jixing Cao,Zheng Gong et al.
Yanxi Wang et al.
The prevalence of ovarian dysfunction is rising annually and trending toward younger populations, significantly compromising the quality of life and reproductive potential of women in their prime childbearing years. Given the multifactorial...
Multi-omics analysis reveals the effects of Jinfeng pills on the outcomes of IVF-ET in patients with poor ovarian response: a randomized controlled trial [0.03%]
基于多组学分析的金凤丸改善卵巢低反应患者IVF-ET结局的随机对照试验
Xumei Kong,Qianwen Luo,Tianhong Huang et al.
Xumei Kong et al.
Background: Jinfeng pills (JFP), a well-known traditional Chinese medicine (TCM) consisted of 9 herbs, benefit Qi, nourish the blood, effectively regulate the menstrual cycle, promote ovulation and improve endometrial thi...
Erzhi Tiangui formula ameliorates ovarian aging by enhancing antioxidant defense via Nrf2/HO-1 signaling [0.03%]
二至天癸丸通过Nrf2/HO-1信号改善抗氧化防御以对抗卵巢衰老
Xiufang Li,Zhongqing Wang,Xiuqing Zhang et al.
Xiufang Li et al.
Objective: This study aimed to investigate the mechanisms through which Erzhi Tiangui Formula (EZTG) mitigates age-related ovarian aging in mice through the Nrf2/HO-1 antioxidant pathway. ...
Single-cell transcriptome analysis in ovarian steroid cell tumors-not otherwise specified [0.03%]
单细胞转录组分析在卵巢类固醇细胞肿瘤中未另行指明
Feiling Huang,Hongyan Chen,Song Mei et al.
Feiling Huang et al.
Background: Ovarian steroid cell tumors-not otherwise specified (SCT-NOS) is a rare category of sex cord-stromal tumor, however, its pathophysiology is unclear. A comprehensive cellular atlas of ovarian SCT-NOS remains la...
Spontaneous natural conception and live birth in three patients with likely pathogenic variants in TUBB8, ZP2, and ZP3 associated with female subfertility [0.03%]
TUBB8、ZP2 和 ZP3 的可能致病突变相关女性不孕患者自然妊娠并活产
Juepu Zhou,Hui He,Ruolin Mao et al.
Juepu Zhou et al.
Case: Three patients with genetically confirmed female subfertility due to heterozygous likely pathogenic variants in TUBB8 (c.613G > A), ZP2 (c.1421T > C), or ZP3 (c.518 C > G), respectively, had histories of recurrent a...
Mendelian randomization in ovarian research: applications in PCOS, ovarian aging, and assisted reproductive technology [0.03%]
卵巢研究中的孟德尔随机化：在多囊卵巢综合征、卵巢衰老和辅助生殖技术中的应用
Ling Lin,Siyuan Liu,Yu Xiang et al.
Ling Lin et al.
Ovarian disorders such as polycystic ovary syndrome (PCOS) and primary ovarian insufficiency (POI) have complex etiologies that are difficult to disentangle using observational studies. Mendelian randomization (MR) offers a powerful approac...
Impact of autoimmune thyroiditis on IVF outcomes in patients with polycystic ovary syndrome and chronic endometritis [0.03%]
自身免疫性甲状腺炎对多囊卵巢综合征合并慢性子宫内膜炎患者体外受精结局的影响
Dingran Wang,Zheng Wang,Hongbin Chi et al.
Dingran Wang et al.
Question: To investigate the impact of autoimmune thyroiditis (AIT) on IVF/ICSI outcomes in patients with polycystic ovary syndrome (PCOS) and chronic endometritis (CE). ...
Targeting the gut microbiome: an integrated probiotic and prebiotic strategy for polycystic ovary syndrome management [0.03%]
针对肠道微生物组的聚糖囊肿卵巢综合征管理的益生元和益生菌综合策略目标研究
Muchu Ni,Qin Wang,Tao Ye et al.
Muchu Ni et al.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder in which gut dysbiosis acts as a key environmental driver. This review synthesizes how probiotics and prebiotics remodel the gut ecosystem and ameliorate PCOS thro...
Modeling fertile window differences across the reproductive lifespan with quantitative urine hormone monitoring of the menstrual cycle [0.03%]
定量尿激素监测月经周期以模拟生殖寿命中排卵窗口的差异
Thomas P Bouchard,Richard J Fehring,Maria Meyers et al.
Thomas P Bouchard et al.
Background: Reproductive hormones of the fertile window are often referenced to women in regular cycles, but this may not be representative of the hormonal profiles of women in different circumstances like polycystic ovar...