Distinct pregnancy challenges in PCOS women undergoing IVF/ICSI with singleton and twin births: a propensity-matched analysis [0.03%]
多囊卵巢综合征妇女接受IVF/ICSI单胎和双胞胎妊娠的独特挑战：倾向匹配分析
Zhekun Zhao,Minyue Tang,Shan Wan et al.
Zhekun Zhao et al.
Background: Polycystic ovary syndrome (PCOS) has been associated with adverse pregnancy outcomes; however, current literature presents inconsistent findings, probably due to varying feotal numbers included in previous res...
The central role of hyperandrogenism in driving metabolic dysfunction in polycystic ovary syndrome: from pathophysiological mechanisms to targeted therapies [0.03%]
多囊卵巢综合征中高雄激素症在代谢紊乱中的中心作用：从病理生理机制到靶向治疗
Jinghui Xu,Bing He
Jinghui Xu
Polycystic ovary syndrome is a prevalent endocrine disorder wherein hyperandrogenism plays a central pathogenic role that extends beyond its reproductive manifestations. This review systematically elucidates the pathophysiological mechanism...
Overall survival and long-term safety of olaparib maintenance in patients with platinum-sensitive relapsed ovarian cancer: final analyses of phase III L-MOCA trial [0.03%]
奥拉帕利维持治疗铂敏感复发性卵巢癌患者的总生存和长期安全性：III期L-MOCA试验的最终分析
Xingzhe Liu,Dan Liu,Zikun Peng et al.
Xingzhe Liu et al.
Background: The indications for Poly(ADP-ribose) polymerase (PARP) inhibitor maintenance therapy in platinum-sensitive recurrent ovarian cancer (PSROC) patients varies across nations. The lack of clinical trial evidence a...
The crosslink between autophagy and ferroptosis in polycystic ovary syndrome: from synergistic pathogenesis to targeted therapy [0.03%]
多囊卵巢综合征自噬和铁死亡的相互联系：从协同发病机制到靶向治疗
Xujin Wu,Jiarui Li,Xuesong Zhang et al.
Xujin Wu et al.
Polycystic ovary syndrome (PCOS) is a highly heterogeneous endocrine-metabolic disorder whose core pathological features-follicular atresia and ovulatory dysfunction-are attributed to functional failure of ovarian granulosa cells (GCs). Alt...
Two compound heterozygous MEIOSIN (likely) pathogenic variants cause female infertility with premature ovarian insufficiency through the disruption of meiosis-related gene transcription [0.03%]
两个复合杂合的MEIOSIN（可能是致病性的）变异通过破坏与减数分裂相关的基因转录而导致女性不孕和早发性卵巢功能不全
Xuan Sha,Yan Zhang,Xun Xia et al.
Xuan Sha et al.
Background: Premature ovarian insufficiency (POI) is a major contributor to female infertility; however, its genetic basis remains insufficiently understood. MEIOSIN is crucial for initiating meiosis by activating a subse...
Luteinizing hormone change trajectories in gonadotropin-releasing hormone antagonist protocols are associated with assisted reproductive outcomes: results from a retrospective cohort study [0.03%]
促性腺激素释放激素拮抗剂方案中黄体生成素变化轨迹与辅助生殖结局相关：一项回顾性队列研究的结果
Xun Su,Qi Zheng,Dongyang Zhang et al.
Xun Su et al.
Context: Luteinizing hormone (LH) plays an integral role in follicular development. In gonadotropin-releasing hormone (GnRH) antagonist protocols, LH levels have been demonstrated to affect assisted reproductive technolog...
Impact of salpingectomy on ovarian response to hormonal stimulation in in vitro fertilization (IVF) cycles [0.03%]
输卵管切除术对体外受精周期激素刺激卵巢反应的影响
Yohan Benchimol,Stéphane Sanchez,Catherine Racowsky et al.
Yohan Benchimol et al.
Background: The coagulation-section of the mesosalpinx during the salpingectomy can lead to injuries on the ovarian vascularization, and thus to the ovarian response to hormonal stimulation. Does salpingectomy affect nega...
Reevaluating statistical methods for proportion-based laboratory outcomes in assisted reproduction [0.03%]
辅助生殖中基于比例的实验室结果的统计方法的再评价
Chaofeng Wei,Hsun-Ming Chang,Chenggang Wang et al.
Chaofeng Wei et al.
Background: Proportion-based laboratory outcomes in assisted reproductive technology (ART), including two-pronuclear fertilization rate, good-quality embryo rate, and blastocyst formation rate, are widely used to evaluate...
Intraperitoneal ZP123 improves aged oocyte quality by restoring granulosa cell gap junctions and improving mitochondrial function [0.03%]
腹腔注射ZP123通过恢复颗粒细胞缝隙连接和改善线粒体功能来提高衰老卵母细胞的质量
Hui Teng,Qijun Xie,Cheng Zhou et al.
Hui Teng et al.
Background: Female reproductive aging is the most critical determinant of decreased fertility because the quality of oocytes gradually deteriorates with age, leading to poor embryo development, increased miscarriage rates...
Oncofertility outcomes after fertility-sparing surgery for borderline ovarian tumors: results of a large retrospective study [0.03%]
一项大规模回顾性研究：卵巢交界性肿瘤保留生育功能手术后患者的生殖结局
Rongmin Wang,Yinping Xiao,Taniya Fernando et al.
Rongmin Wang et al.
Background: Fertility-sparing surgery (FSS) is a key therapeutic strategy for borderline ovarian tumors (BOTs) in young women. However, the optimal surgical approaches and the prognostic significance of clinicopathologica...