Calcitriol is involved in maintaining primordial follicle reserve through the inhibition of the PI3K/Akt signaling pathway [0.03%]
钙三醇通过抑制PI3K/Akt信号通路维持原始卵泡库数量
Shuang Liu,Ye Chen,Hongwei Wei et al.
Shuang Liu et al.
Background: In mammals, precise regulation of primordial follicle activation is essential for maintaining the female reproductive lifespan. In this study, we demonstrated that the vitamin D receptor (VDR) is expressed in ...
Dissecting the transcriptomic signature of porcine oocyte during primordial follicle formation from single cell resolution [0.03%]
从单细胞分辨率解析猪卵泡在原始卵泡形成过程中的转录组特征
Xin-Hao Zhang,Kai Zhang,Yu Tian et al.
Xin-Hao Zhang et al.
Background: Ovarian reserve, refers to the number of primordial follicle (PF) in mammals, is a decisive factor affecting the reproductive lifespan of females. However, the molecular mechanism of PF formation has not been ...
Ubiquitin-specific proteases in ovarian cancer: molecular mechanisms and therapeutic implications [0.03%]
卵巢癌中泛素特异性蛋白酶的分子机制及其治疗意义
Lu Deng,Yuzhao Jiang,Danning Wang et al.
Lu Deng et al.
Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, largely due to late-stage diagnosis, frequent recurrence, and the development of resistance to standard therapies. These clinical challenges highlight the urgent...
Ovarian tissue oocyte-in vitro maturation combined with ovarian tissue cryopreservation: a promising urgent fertility preservation strategy for hematological patients before HSCT [0.03%]
卵巢组织卵母细胞体外成熟与卵巢组织冻存结合的非创伤性紧急生育力保存策略在血液系统疾病患者造血干细胞移植前的应用前景
Yingqiao Ding,Tiantian Su,Yanling Wan et al.
Yingqiao Ding et al.
Background: Hematological diseases to be treated with HSCT are a definite indication for fertility preservation (FP). Ovarian tissue oocyte in vitro maturation (OTO-IVM) combined with ovarian tissue cryopreservation (OTC)...
Progress of estrogen receptor and splice variants in ovarian carcinoma [0.03%]
卵巢癌中的雌激素受体及剪切变异体的研究进展
Ting Mo,Ziqi Hong,Youqiong Mo et al.
Ting Mo et al.
Ovarian cancer is a typical estrogen-dependent tumor, with its initiation and progression closely associated with estrogen regulation. Estrogen exerts physiological effects by binding to estrogen receptors (ERs), and aberrant activation of ...
Hyperhomocysteinemia reduces the high-quality embryo rate in PCOS patients undergoing IVF/ICSI: clinical evidence and a preliminary exploration of mechanisms in KGN cells [0.03%]
高同型半胱氨酸血症通过影响卵巢颗粒细胞能量代谢和凋亡降低多囊卵巢综合征患者IVF/ICSI周期优质胚胎率：临床证据及机制初探
Haofei Shen,Tianyu Jia,Xiaorong Luo et al.
Haofei Shen et al.
Background: Homocysteine (Hcy) is a sulfur-containing intermediate metabolite during methionine metabolism. Studies indicate that individuals with polycystic ovary syndrome (PCOS) have higher circulating Hcy levels relati...
Metaphase I-arrest oocyte with agar-like zona pellucida, abandon or not abandon? [0.03%]
透明带像果冻样的第一极体期卵子，救还是不救？
Juepu Zhou,Qingsong Xi,Meng Wang et al.
Juepu Zhou et al.
Background: The morphological appearance of zona pellucida (ZP) is considered to be predictive of the quality of the oocytes and embryos. Agar-like ZP represents a common type of ZP abnormality, which is usually associate...
Loss of DLGAP5 impairs human and mouse oocyte maturation via disrupting the PI3K-AKT signaling axis [0.03%]
DLGAP5丢失通过破坏PI3K-AKT信号轴损害卵母细胞成熟
Meng Wang,Juepu Zhou,Youzhu Li et al.
Meng Wang et al.
Background: At present, the known genetic causes of abnormal oocyte development can only account for a minority of female infertility. In our previous study, the mutation c.1101 C > G, p.Tyr367* in discs large-associated ...
Qian Wang,Guodong Zhao,Jiaqi Zhou
Qian Wang
As the earliest aging organ in females, the ovary undergoes functional decline and structural senescence that drive reproductive system alterations. Central to this process is the primordial follicle-the non-renewable reserve of female germ...
Decreased expression of ribonucleotide reductase M2 accelerates ovarian aging by suppressing cell proliferation and inducing DNA damage in mouse theca-interstitial cells [0.03%]
RRM2表达沉默通过抑制细胞增殖和诱导DNA损伤加速小鼠卵巢颗粒细胞衰老
Rula Sa,Xiang Zhang,Kesong Shi et al.
Rula Sa et al.
Natural aging affects the ovary, leading to declining function and age-related female infertility. This study investigated the role of theca-interstitial cells (TICs) in ovarian aging, a previously understudied area. Transcriptomic analysis...