The contribution of rare germline variants to the immune landscape of breast cancer [0.03%]
乳腺癌免疫图谱中罕见种系变异的贡献
Felipe Rojas-Rodríguez,Sander Canisius,Renske Keeman et al.
Felipe Rojas-Rodríguez et al.
Background: Many breast cancer predisposition genes are involved in DNA damage repair, leading to genome instability that can impact immunosurveillance, neoantigen formation, and the composition of the tumor immune microe...
African ancestry and risk variants associated with triple-negative breast cancer susceptibility in African American women [0.03%]
非洲血统与三阴性乳腺癌风险变异体相关的易感性在美国非裔女性中的研究
Guochong Jia,Lili Liu,Jie Ping et al.
Guochong Jia et al.
Background: Compared to European American women, African American women are more likely to be diagnosed with triple-negative breast cancer (TNBC). This difference may be partially due to genetic factors. This study aims t...
Survival Genie 2: a next-generation web server for targeted and single-cell-based survival analyses [0.03%]
Survival Genie 2：一个面向生存分析的下一代网络服务器
Chenbin Huang,Marina E Michaud,Hope Mumme et al.
Chenbin Huang et al.
Background: With the growing number of publicly available cancer genomics datasets, numerous web-based survival analysis tools have been developed to link gene expression data with patient outcomes, aiming to discover nov...
Twelve years of genomic surveillance of vancomycin-resistant Enterococcus faecium: emergence of linear vanA and bacteriocin-carrying plasmids challenging infection control [0.03%]
艰难梭菌耐万古霉素肠球菌基因组监测12年：线性vanA质粒和细菌素携带质粒的出现对感染控制带来挑战
Ana C Almeida-Santos,Ana P Tedim,Bárbara Duarte et al.
Ana C Almeida-Santos et al.
Background: The epidemiology of vancomycin-resistant Enterococcus faecium (VREfm) varies across different countries, with a steady global increase. In Portugal, however, epidemiological data on clinical VREfm have been sc...
Comprehensive molecular characterization identifies therapeutic vulnerabilities in ovarian clear cell carcinoma [0.03%]
全面分子特征分析确定了卵巢透明细胞癌的治疗弱点
Yong Wu,Xinyi Guo,Tiantian Wang et al.
Yong Wu et al.
Background: Ovarian clear cell carcinoma (OCCC) is a rare aggressive, and chemo-resistant subtype of epithelial ovarian cancer. Current limitations in precisely characterizing its molecular features have resulted in restr...
Kristen Schulz,Steven R Botts,Kai Ellis et al.
Kristen Schulz et al.
Background: Endothelial cells (ECs) orchestrate vascular homeostasis and resilience but can undergo reprogramming into a mesenchymal-like phenotype through an endothelial-to-mesenchymal transition (EndMT). Crucially, EndM...
Integrative multi-omics profiling reveals distinct evolutionary and immunogenic features of brain oligometastasis in lung adenocarcinoma [0.03%]
整合多组学谱型揭示肺腺癌脑寡转移的独特进化和免疫特征
Rongxin Liao,Qian Yu,Yusheng Huang et al.
Rongxin Liao et al.
Background: Emerging evidence has demonstrated that lung cancer patients with brain oligometastases (oligo-BMs) could benefit from local radical therapies. Despite rapid advancements in the treatment of oligometastatic di...
The impact of the COVID-19 pandemic and associated lifestyle changes on early-life microbiome development [0.03%]
新冠疫情及其伴随的生活方式改变对生命早期微生物组发展的影响
Evgenia Dikareva,Niels van Best,Liene Bervoets et al.
Evgenia Dikareva et al.
Background: The COVID-19 pandemic triggered rapid, population-wide behavioral and environmental changes, offering a unique natural experiment to study how early-life microbiome development responds to abrupt shifts in soc...
Functional germline variants together with somatic mutations alter the integrity of cancer hallmark regulatory networks [0.03%]
功能性胚细胞突变和体细胞突变共同改变癌症标志调控网络的完整性
Jiawei Dai,Mate Posta,Michal Marczyk et al.
Jiawei Dai et al.
Background: How germline and somatic alterations together contribute to alterations in cancer relevant pathways in individual cancers remains poorly understood. In this study, we provide a quantitative framework to charac...
Single base focal hypermutation cooccurs with structural variation as an early event in advanced prostate tumourigenesis with ancestry specific independence: a multi-ancestral observational study [0.03%]
单核苷酸焦点高突变与结构变异共同作为晚期前列腺肿瘤发生的早期事件：一种多谱系观察性研究
Jue Jiang,Avraam Tapinos,Ruotian Huang et al.
Jue Jiang et al.