Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics [0.03%]
来自新生儿的肠外病原性大肠杆菌的全面基因组特征分析：多中心视角下的毒力、耐药性和传播动力学
Dongmiao Zhang,Yijun Ding,Wenqing Kang et al.
Dongmiao Zhang et al.
Background: Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack ...
Multicenter Study
Genome medicine. 2026 Aug 5;18(1):118. DOI:10.1186/s13073-026-01717-8 2026
Multifeature sequencing-based liquid biopsy for cancer diagnosis and monitoring [0.03%]
基于多重特征序列的液体活检在癌症诊断和监测中的应用
Mariano A Molina,Martina De Simoni,Norbert Moldovan et al.
Mariano A Molina et al.
Liquid biopsy has emerged as a transformative development in oncology, enabling the minimally invasive detection and monitoring of cancer through the analysis of tumor-derived material in blood. Moving beyond single-variable analysis, multi...
Single-cell analysis of the progeria arterial wall reveals progerin-induced progressive, cell type-specific dysfunction and somatic mutation accumulation [0.03%]
单细胞测序揭示早老症动脉壁中衰老蛋白引起的功能障碍和体细胞性突变累积
Lara G Merino,Gwladys Revêchon,Santhilal Subhash et al.
Lara G Merino et al.
Background: The premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by de novo LMNA mutations producing the aberrant Lamin A isoform progerin. HGPS patients die from cardiovascular disease, with...
Circulating tumor DNA precision oncology enables effective and sensitive molecular diagnostics and actionable target detection in pediatric solid tumors - the INFORM experience [0.03%]
循环肿瘤DNA的精准肿瘤学使儿童实体瘤的有效和灵敏分子诊断以及可操作靶点检测成为可能——来自INFORM试验的经验总结
Kendra K Maass,Pitithat Puranachot,Stefanie Volz et al.
Kendra K Maass et al.
Background: Pediatric solid high-risk malignancies mostly lack established molecular biomarkers for early detection, minimal residual disease assessment, or treatment monitoring. Challenges include small patient numbers, ...
clinTALL: machine learning-driven multimodal subtype classification and treatment outcome prediction in pediatric T-ALL [0.03%]
clinTALL：基于机器学习的儿童T细胞急性淋巴细胞白血病亚型分类及治疗结果预测模型
Lukas Stoiber,Željko Antić,Stefano Rebellato et al.
Lukas Stoiber et al.
Background: Childhood T-lineage acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with poor prognosis. Differently from B-cell precursor ALL, T-ALL lacks effective risk stratification strategies...
Correction: Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration [0.03%]
纠正：患者诱导多能干细胞识别年龄相关性黄斑变性网状假玻璃膜疣表型的特异性
Jenna C Hall,Kavitha Krishna Sudhakar,Maciej Daniszewski et al.
Jenna C Hall et al.
Published Erratum
Genome medicine. 2026 Jul 22;18(1):107. DOI:10.1186/s13073-026-01728-5 2026
Towards culture-free sequencing of Mycobacterium tuberculosis: evaluating new targeted and whole-genome approaches for genotyping and drug resistance profiling [0.03%]
无菌培养直接进行结核分枝杆菌基因分型和耐药性检测的新方法研究
Ilaria Iannucci,Federico Di Marco,Kiarash Moghaddasi et al.
Ilaria Iannucci et al.
Background: The effectiveness of current drug-resistant tuberculosis (DR-TB) regimens is limited by the absence of rapid diagnostics that comprehensively predict resistance to included drugs. Next-generation sequencing (N...
Multiomic approaches identify a rare CCG repeat expansion in BCLAF3 in neurodevelopmental disorders [0.03%]
多组学方法识别出神经发育障碍中BCLAF3基因CCG重复序列扩增这一罕见原因
Christy W LaFlamme,Chris Clarkson,Kristina Ibañez et al.
Christy W LaFlamme et al.
Background: Tandem repeat expansions have been implicated in various neurological conditions. Here, we present a novel hypermethylated CCG repeat expansion on Xp22 in the 5'UTR of BCLAF3 in males with neurodevelopmental d...
Multi-threshold polygenic risk improves hippocampal-based cognitive decline prediction [0.03%]
多阈值的多基因风险评分可改善以海马体为基础的认知衰退预测能力
Mohammed Janahi,Luigi Lorenzini,Neil P Oxtoby et al.
Mohammed Janahi et al.
Background: Predicting cognitive decline from brain MRI is a central question in neuroscience. Hippocampal volume (HV) is a key cognitive biomarker, and normative models can be augmented with multimodal information. Here ...
A short-term randomized clinical trial testing feasibility of and physiological responses to a Ruminococcus torques strain in healthy overweight humans [0.03%]
一项短期随机临床试验：测试罗氏肠球菌菌株在健康超重人类中的可行性及生理反应
Joachim Gæde,Yong Fan,Liwei Lyu et al.
Joachim Gæde et al.
Background: The human gut microbiota interacts with host biology as exemplified by the effects of the Ruminococcus torques (RT) ATCC 27756 strain-a commensal human intestinal bacterial strain that synthesizes the polypept...