Detection of primary cancer types via fragment size selection in circulating cell-free extrachromosomal circular DNA [0.03%]
通过循环细胞外染色体外环状DNA的片段大小选择检测原发癌类型
Jingwen Fang,Songwen Luo,Shouzhen Li et al.
Jingwen Fang et al.
Multi-omics reveals cholesterol-driven macrophage metabolic reprogramming and inflammation in chronic obstructive pulmonary disease [0.03%]
多组学揭示胆固醇驱动的慢性阻塞性肺疾病巨噬细胞代谢重构及炎症反应
Xinru Ran,Zhandong Yang,Li Cheng et al.
Xinru Ran et al.
An integrated platform for concurrent structural and single-nucleotide variants improves copy-number detection and reveals pathogenic alleles in undiagnosed Mendelian families [0.03%]
一种集成平台可同时进行结构变异和单核苷酸变异的一体化分析，有助于提高拷贝数检测并揭示未知病原基因型
Haowei Du,Ming Yin Lun,Lidiia Gagarina et al.
Haowei Du et al.
Background: Copy number variation (CNV) is a class of genomic structural variation (SV) that contributes to genomic disorders and can significantly impact health. Short-read genome sequencing (sr-GS) enables genome-wide S...
Genetic characterization and screening of congenital adrenal hyperplasia by long-read sequencing in a cohort of 21,239 newborns [0.03%]
基于长读测序技术的先天性肾上腺皮质增生症基因特征分析及新生儿筛查研究（21,239例）
Desheng Liang,Min Zhu,Qiaowei Liang et al.
Desheng Liang et al.
Single-cell RNA-seq analysis of longitudinal CD4+ T cell samples reveals cell-type-specific changes during early stages of type 1 diabetes [0.03%]
单细胞RNA测序分析纵向CD4+T细胞样本以揭示1型糖尿病早期阶段的特定细胞类型变化
Rahul Biradar,Ubaid Ullah Kalim,Tapio Lönnberg et al.
Rahul Biradar et al.
Background: T cells play a pivotal role in the autoimmune destruction of beta cells in type 1 diabetes. However, our understanding of the disease has been limited by lack of a comprehensive single-cell transcriptome analy...
NeoGuider: neoepitope prediction using advanced feature engineering [0.03%]
NeoGuider：利用先进特征工程的新生抗原预测
Xiaofei Zhao,Lei Wei,Zhen Xie et al.
Xiaofei Zhao et al.
The design of neoepitope-based cancer immunotherapy requires predicting the immunogenicity of each patient-specific neoepitope candidate. We designed NeoGuider, a machine-learning model to address nonlinearity and class imbalance in such pr...
Airway transcriptome networks for ozone and PM2.5 exposure reveal distinct key drivers for children with asthma [0.03%]
儿童哮喘患者暴露于臭氧和PM2.5的气道转录组网络揭示了不同的关键驱动因素
Yoojin Chun,Haritz Irizar,Lingdi Zhang et al.
Yoojin Chun et al.
Background: Air pollution disproportionately affects individuals with asthma, triggering asthma exacerbations and morbidity. We hypothesized that children with and without asthma have distinct airway transcriptome network...
Reference-guided computational framework identifies microenvironment metabolic subtypes and targets using pan-cancer single-cell datasets [0.03%]
基于参考的计算框架通过泛癌单细胞数据集识别微环境代谢亚型和靶点
Ke Tang,Ya Han,Dongqing Sun et al.
Ke Tang et al.
Background: Metabolic reprogramming is a hallmark of cancer; however, the mechanisms driving metabolic heterogeneity across diverse cell types in the tumor microenvironment remain poorly understood. Most existing methods ...
Jake R Saklatvala,Samuel Lessard,Maris Teder-Laving et al.
Jake R Saklatvala et al.
Background: Psoriasis is a common inflammatory skin disease with heterogeneous presentation. Up to 30% of individuals have severe disease with a greater surface area of skin involvement, co-morbidity burden and impact on ...
Delineation and monitoring of the T cell repertoire of adoptive cell transfer product during the treatment of advanced melanoma [0.03%]
T细胞受体鉴定和监测在转移性黑色素瘤治疗中的适应性细胞移植产品
Cameron Kerr,Shirin Soleimani,David T Mulder et al.
Cameron Kerr et al.