Steven Henikoff,Frank Grosveld
Steven Henikoff
Christoffel Dinant,Adriaan B Houtsmuller,Wim Vermeulen
Christoffel Dinant
The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. These damaging agents can induce a wide variety of lesions in the DNA, such as double strand breaks, single strand breaks, oxidativ...
Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes [0.03%]
小鼠、牛和兔受精卵中保守的DNA及组蛋白H3甲基化重编程证据
Konstantin Lepikhov,Valeri Zakhartchenko,Ru Hao et al.
Konstantin Lepikhov et al.
Background: In mammals the parental genomes are epigenetically reprogrammed after fertilization. This reprogramming includes a rapid demethylation of the paternal (sperm-derived) chromosomes prior to DNA replication in zy...
Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting: application to the CDKN2B (p15) gene [0.03%]
利用数字化甲基敏感性高分辨率熔解快速分析异质性甲基化DNA及其在CDKN2B(p15)基因中的应用研究
Ida L M Candiloro,Thomas Mikeska,Peter Hokland et al.
Ida L M Candiloro et al.
Background: Methylation-sensitive high resolution melting (MS-HRM) methodology is able to recognise heterogeneously methylated sequences by their characteristic melting profiles. To further analyse heterogeneously methyla...
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence [0.03%]
端粒和非端粒DNA损伤都是哺乳动物细胞衰老的决定因素
Asako J Nakamura,Y Jeffrey Chiang,Karen S Hathcock et al.
Asako J Nakamura et al.
Background: Cellular senescence is a state reached by normal mammalian cells after a finite number of cell divisions and is characterized by morphological and physiological changes including terminal cell-cycle arrest. Th...
The fungus Neurospora crassa displays telomeric silencing mediated by multiple sirtuins and by methylation of histone H3 lysine 9 [0.03%]
曲霉菌Neurospora crassa通过组蛋白H3赖氨酸9甲基化和多个沉默素介导的端粒沉默反应显示基因沉默现象
Kristina M Smith,Gregory O Kothe,Cindy B Matsen et al.
Kristina M Smith et al.
Background: Silencing of genes inserted near telomeres provides a model to investigate the function of heterochromatin. We initiated a study of telomeric silencing in Neurospora crassa, a fungus that sports DNA methylatio...
Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy [0.03%]
高时间分辨率显微镜解析活体人类细胞中的端粒快速运动现象
Xueying Wang,Zvi Kam,Peter M Carlton et al.
Xueying Wang et al.
Background: Telomeres cap chromosome ends and protect the genome. We studied individual telomeres in live human cancer cells. In capturing telomere motions using quantitative imaging to acquire complete high-resolution th...