Tissue-specific variation in DNA methylation levels along human chromosome 1 [0.03%]
人类1号染色体上组织特异性的DNA甲基化水平差异
Cecilia De Bustos,Edward Ramos,Janet M Young et al.
Cecilia De Bustos et al.
Background: DNA methylation is a major epigenetic modification important for regulating gene expression and suppressing spurious transcription. Most methods to scan the genome in different tissues for differentially methy...
DNA replication and the GINS complex: localization on extended chromatin fibers [0.03%]
DNA复制和GINS复合物：在延长的染色质纤维上的定位
Stephanie M Cohen,Paul D Chastain nd,Marila Cordeiro-Stone et al.
Stephanie M Cohen et al.
Background: The GINS complex is thought to be essential for the processes of initiation and elongation of DNA replication. This complex contains four subunits, one of which (Psf1) is proposed to bind to both chromatin and...
The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis [0.03%]
组蛋白3赖氨酸4甲基转移酶Mll2仅在发育和精子发生中短暂需要
Stefan Glaser,Sandra Lubitz,Kate L Loveland et al.
Stefan Glaser et al.
Background: Histone methylation is thought to be central to the epigenetic mechanisms that maintain and confine cellular identity in multi-cellular organisms. To examine epigenetic roles in cellular homeostasis, we condit...
Multiple sequence-directed possibilities provide a pool of nucleosome position choices in different states of activity of a gene [0.03%]
多个序列导向的可能选择构成了基因不同活性状态下的核小体位置选择池
Vinesh Vinayachandran,Rama-Haritha Pusarla,Purnima Bhargava
Vinesh Vinayachandran
Background: Genome-wide mappings of nucleosome occupancy in different species have shown presence of well-positioned nucleosomes. While the DNA sequences may help decide their locations, the observed positions in vivo are...
Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation [0.03%]
基于硫酸盐的表型分型鉴定出群体基因组DNA甲基化平均水平的准确估计值
Sophia J Docherty,Oliver S P Davis,Claire M A Haworth et al.
Sophia J Docherty et al.
Background: DNA methylation plays a vital role in normal cellular function, with aberrant methylation signatures being implicated in a growing number of human pathologies and complex human traits. Methods based on the mod...
Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes [0.03%]
酿酒酵母Sgf73 / Ataxin-7可将去泛素化模块锚定至SAGA和Slik（SALSA）乙酰转移酶复合体中
Kenneth K Lee,Selene K Swanson,Laurence Florens et al.
Kenneth K Lee et al.
Spinocerebellar ataxia (SCA) is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. There are many types of SCAs as t...
High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model [0.03%]
果蝇位置效应嵌斑模型异染色质重分布的高分辨率定位研究
Maartje J Vogel,Ludo Pagie,Wendy Talhout et al.
Maartje J Vogel et al.
Background: Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that ...
Hongda Wang,Yamini Dalal,Steven Henikoff et al.
Hongda Wang et al.
Background: Direct visualization of chromatin has the potential to provide important insights into epigenetic processes. In particular, atomic force microscopy (AFM) can visualize single nucleosomes under physiological io...
Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development [0.03%]
程序性DNA重组过程中染色质的时空可塑性——以Stylonychia.macronuclear发育为例
Jan Postberg,Katharina Heyse,Marion Cremer et al.
Jan Postberg et al.
Background: In this study we exploit the unique genome organization of ciliates to characterize the biological function of histone modification patterns and chromatin plasticity for the processing of specific DNA sequence...
Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a [0.03%]
Dicer通过转录调控Dnmt3a间接调节ES细胞中Xist启动子的甲基化状态
Tatyana B Nesterova,Bilyana C Popova,Bradley S Cobb et al.
Tatyana B Nesterova et al.
Background: X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non...