CTCF regulates the local epigenetic state of ribosomal DNA repeats [0.03%]
CTCF调控核糖体DNA重复序列的局部表观遗传状态
Suzanne van de Nobelen,Manuel Rosa-Garrido,Joerg Leers et al.
Suzanne van de Nobelen et al.
Background: CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription. CTCF may act ...
Lessons from genome-wide studies: an integrated definition of the coactivator function of histone acetyl transferases [0.03%]
染色体宽检视的启示：组蛋白乙酰转移酶活化功能的综合定义
Krishanpal Anamika,Arnaud R Krebs,Julie Thompson et al.
Krishanpal Anamika et al.
Histone acetylation is one of the key regulatory mechanisms controlling transcriptional activity in eukaryotic cells. In higher eukaryotes, a number of nuclear histone acetyltransferase (HAT) enzymes have been identified, most of which are ...
Dynamic instability of genomic methylation patterns in pluripotent stem cells [0.03%]
多能干细胞中基因组甲基化模式的动态不稳定性
Steen Kt Ooi,Daniel Wolf,Odelya Hartung et al.
Steen Kt Ooi et al.
Background: Genomic methylation patterns are established during gametogenesis, and perpetuated in somatic cells by faithful maintenance methylation. There have been previous indications that genomic methylation patterns m...
Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1) [0.03%]
男性和RNF20的招募与动态组蛋白修饰相关，这种修饰调节信号转导及转录激活因子1（STAT1）激活的干扰素调节因子1基因（IRF1）的转录
Lauren J Buro,Edmond Chipumuro,Melissa A Henriksen
Lauren J Buro
Background: Signal transducer and activator of transcription (STAT) activation of gene expression is both rapid and transient, and when properly executed it affects growth, differentiation, homeostasis and the immune resp...
Trans-generational epigenetic regulation of C. elegans primordial germ cells [0.03%]
秀丽隐杆线虫原始生殖细胞的跨世代表观遗传调控机制研究
Hirofumi Furuhashi,Teruaki Takasaki,Andreas Rechtsteiner et al.
Hirofumi Furuhashi et al.
Background: The processes through which the germline maintains its continuity across generations has long been the focus of biological research. Recent studies have suggested that germline continuity can involve epigeneti...
MacroH2A subtypes contribute antagonistically to the transcriptional regulation of the ribosomal cistron during seasonal acclimatization of the carp fish [0.03%]
巨鱼鳞酸组蛋白H2A参与调节鲤鱼季节驯化的核糖体基因转录
I Araya,G Nardocci,Jp Morales et al.
I Araya et al.
Background: Incorporation of histone variants into chromatin is one of the epigenetic mechanisms used for regulation of gene expression. Macro (m)H2A is a histone variant that has two different subtypes in vertebrates: mH...
An in vitro-identified high-affinity nucleosome-positioning signal is capable of transiently positioning a nucleosome in vivo [0.03%]
一个高亲和力的组蛋白八聚体定位DNA序列在体内具有暂时定位核小体的能力
Lia E Gracey,Zhi-Ying Chen,Jay M Maniar et al.
Lia E Gracey et al.
Background: The physiological function of eukaryotic DNA occurs in the context of nucleosomal arrays that can expose or obscure defined segments of the genome. Certain DNA sequences are capable of strongly positioning a n...
A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation [0.03%]
结合HM-PCR和SNuPE法进行高灵敏度的稀有甲基化DNA检测
Sascha Tierling,Matthias Schuster,Reimo Tetzner et al.
Sascha Tierling et al.
Background: DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or compl...
Extensive sequence-influenced DNA methylation polymorphism in the human genome [0.03%]
人类基因组中由序列影响的DNA甲基化多态性广泛存在
Asaf Hellman,Andrew Chess
Asaf Hellman
Background: Epigenetic polymorphisms are a potential source of human diversity, but their frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an epigenetic mark that is a covalent modificatio...
Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation [0.03%]
Xist介导的常染色体沉默效率与染色体区室组织相关
Y Amy Tang,Derek Huntley,Giovanni Montana et al.
Y Amy Tang et al.
Background: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xi...