H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development [0.03%]
H3K4me3通过调节真皮乳头细胞中RSPO3的转录来影响毛囊形态发生及发育
Zhenyu Zhong,Kangkang Bai,Zhihao Song et al.
Zhenyu Zhong et al.
Morphogenesis and development of hair follicle fundamentally depend on the interaction between the epidermis and dermis, with dermal papilla cells (DPCs) playing a critical role in these processes. H3K4me3, one of the key histone modificati...
Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena [0.03%]
溴结构域蛋白IBD1和IBD2将组蛋白乙酰化与四膜虫SWR1及INO80介导的H2A.Z调节联系起来
Jyoti Garg,Alejandro Saettone,Syed Nabeel-Shah et al.
Jyoti Garg et al.
Background: INO80 and SWR1 are evolutionarily related ATP-dependent chromatin remodeling complexes that regulate the chromatin occupancy of the histone variant H2A.Z, playing critical roles in transcriptional regulation, ...
Dynamic epigenomic landscape and gene regulatory networks during embryonic development in Pacific white shrimp (Litopenaeus vannamei) as revealed by histone modification profiling using CUT&Tag [0.03%]
基于CUT&Tag表观遗传修饰组测序解析南美白对虾胚胎发育过程中的动态基因调控网络及表观景观
Jiale Shi,Zhangru Qi,Miaomiao Yin et al.
Jiale Shi et al.
Background: The Pacific white shrimp (Litopenaeus vannamei) is the most widely farmed shrimp species globally, yet the epigenetic regulation underlying its embryonic development remains largely unexplored. Histone modific...
Insulator BEAF32 regulates expression of tissue-specific genes and piRNA source loci in Drosophila ovaries [0.03%]
绝缘子BEAF32调控果蝇卵巢中组织特异性基因和piRNA源位点的表达
Anastasia A Kobelyatskaya,Valeria Morgunova,Aleksey Kalinkin et al.
Anastasia A Kobelyatskaya et al.
Background: Insulators are the multifunctional DNA binding proteins that perform architectural functions and regulate gene transcription. Although insulators have a well-established role in genome organization, it is stil...
Histone H4 lysine 20 methylation marks genes dynamically regulated during erythroid maturation [0.03%]
组蛋白H4第20位赖氨酸甲基化修饰在红细胞成熟过程中动态调节基因的表达
Kristin Murphy,Michael Getman,Xiurui Lv et al.
Kristin Murphy et al.
Background: Methylation of H4K20 has been implicated in the regulation of gene expression but also plays essential roles in numerous cellular functions, making studies of its effects on transcription challenging. To gain ...
Identification of genetic and non-genetic modifiers of genomic imprinting through screening of imprinted DMR methylation in humans [0.03%]
通过筛查人类基因组印记区域的DNA甲基化来鉴定调控基因组印记的遗传和非遗传修饰因子
Francesco Cecere,Raissa Relator,Michael Levy et al.
Francesco Cecere et al.
Background: Genomic imprinting is required for normal development, and abnormal methylation of differentially methylated regions (iDMRs) controlling the parent of origin-dependent expression of the imprinted genes has bee...
H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation [0.03%]
NAA40介导的H2A.X N端乙酰化修饰响应紫外线照射而发生变化
Ariel Klavaris,Costas Koufaris,Roberta Noberini et al.
Ariel Klavaris et al.
Background: N-terminal acetylation (Nt-Ac), mediated by N-terminal acetyltransferases (NATs) is one of the most abundant protein modifications occurring approximately in 80% of all eukaryotic proteins. In contrast to the ...
Improved epigenetic age prediction models by combining sex chromosome and autosomal markers [0.03%]
通过结合性染色体和常染色体标志物改进表观遗传年龄预测模型
Zhong Wan,Peter Henneman,Huub C J Hoefsloot et al.
Zhong Wan et al.
Background: Alterations in epigenetic DNA methylation (DNAm) can be used as an accurate and robust method for biological age prediction. We assessed the feasibility of incorporating sex chromosomal DNAm markers into a six...
Epigenetic regulation of MED12: a key contributor to the leukemic chromatin landscape and transcriptional dysregulation [0.03%]
MED12的表观遗传调控：白血病基因组景观和转录失调的关键因素
Arundhati Chavan,Cassidy Jones,Whit Lawrence et al.
Arundhati Chavan et al.
Background: MED12 is a key regulator of transcription and chromatin architecture, essential for normal hematopoiesis. While its dysregulation has been implicated in hematological malignancies, the mechanisms driving its u...
Introduction of epigenetic variation contribute to resistance against the human parasite Schistosoma mansoni [0.03%]
表观遗传变异介导的宿主对寄生虫感染抵抗性的差异及其机制研究
Nelia Luviano-Aparicio,Marie Lopez,Bart Haegeman et al.
Nelia Luviano-Aparicio et al.
Background: Waddington-type kick-start of adaptive evolution is assumed to be possible based on epigenetic variation alone. We tested this hypothesis in the snail Biomphalaria glabrata, vector of Schistosoma mansoni, the ...