Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages [0.03%]
胚胎和成人谱系红细胞中鸡β-球蛋白基因域的空间组织
Sergey V Ulianov,Alexey A Gavrilov,Sergey V Razin
Sergey V Ulianov
Background: The β-globin gene domains of vertebrate animals constitute popular models for studying the regulation of eukaryotic gene transcription. It has previously been shown that in the mouse the developmental switchi...
Deacetylation of H4-K16Ac and heterochromatin assembly in senescence [0.03%]
组蛋白H4去乙酰化及异染色质装配在衰老过程中的作用
Kévin Contrepois,Jean-Yves Thuret,Régis Courbeyrette et al.
Kévin Contrepois et al.
Background: Cellular senescence is a stress response of mammalian cells leading to a durable arrest of cell proliferation that has been implicated in tumor suppression, wound healing, and aging. The proliferative arrest i...
Jessica M Stringer,Shunsuke Suzuki,Andrew J Pask et al.
Jessica M Stringer et al.
Background: In marsupials, growth and development of the young occur postnatally, regulated by milk that changes in composition throughout the long lactation. To initiate lactation in mammals, there is an absolute require...
Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene [0.03%]
粘连素是雌激素受体-α(ESR1)基因表达所必需的
Tanja Prenzel,Frank Kramer,Upasana Bedi et al.
Tanja Prenzel et al.
Background: In conjunction with posttranslational chromatin modifications, proper arrangement of higher order chromatin structure appears to be important for controlling transcription in the nucleus. Recent genome-wide st...
MK3 controls Polycomb target gene expression via negative feedback on ERK [0.03%]
MK3通过ERK的负反馈调控Polycomb靶基因表达
Peggy Prickaerts,Hanneke Ec Niessen,Emmanuèle Mouchel-Vielh et al.
Peggy Prickaerts et al.
Background: Gene-environment interactions are mediated by epigenetic mechanisms. Polycomb Group proteins constitute part of an epigenetic cellular transcriptional memory system that is subject to dynamic modulation during...
Richard B Meagher,Kristofer J Müssar
Richard B Meagher
Clear cause-and-effect relationships are commonly established between genotype and the inherited risk of acquiring human and plant diseases and aberrant phenotypes. By contrast, few such cause-and-effect relationships are established linkin...
Lars Grøntved,Russell Bandle,Sam John et al.
Lars Grøntved et al.
Background: The challenge in extracting genome-wide chromatin features from limiting clinical samples poses a significant hurdle in identification of regulatory marks that impact the physiological or pathological state. C...
Rejane Hughes Carvalho,Vanja Haberle,Jun Hou et al.
Rejane Hughes Carvalho et al.
Background: Non-small cell lung carcinoma (NSCLC) is a complex malignancy that owing to its heterogeneity and poor prognosis poses many challenges to diagnosis, prognosis and patient treatment. DNA methylation is an impor...
The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner [0.03%]
CTCFL通过一种核小体组成依赖性方式结合类似于CTCF的共识序列并以功能不同的方式调节雄性生殖细胞基因
Frank Sleutels,Widia Soochit,Marek Bartkuhn et al.
Frank Sleutels et al.
Background: CTCF is a highly conserved and essential zinc finger protein expressed in virtually all cell types. In conjunction with cohesin, it organizes chromatin into loops, thereby regulating gene expression and epigen...
Paul B Talbert,Kami Ahmad,Geneviève Almouzni et al.
Paul B Talbert et al.
Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conventions for them has led to a var...