Dna methylation dynamics associated with visual system remodeling during flatfish metamorphosis [0.03%]
与鱼变态过程中视觉系统重塑相关的DNA甲基化动态变化
Laura Guerrero-Peña,Paula Suarez-Bregua,Nuria Sánchez-Baizán et al.
Laura Guerrero-Peña et al.
Background: Flatfish metamorphosis involves dramatic tissue remodeling, including the migration of one eye to the opposite side of the body, enabling the transition from pelagic to benthic life. While this process require...
DNA methylation reshapes the expression of adipokines and adipose factors in white adipose tissues [0.03%]
DNA甲基化重塑白色脂肪组织中脂连素和脂肪因子的表达
Meng-Yue Fang,Shi-Wei Liu,Prasanna R Kolatkar et al.
Meng-Yue Fang et al.
The expansion of adipose tissue during obesity results in alterations in the expression of adipose-derived hormones or factors, which control whole-body energy metabolism. Epigenetics refers to the heritable modifications in gene function t...
Integrated study of DNA methylation and transcriptome: a new perspective for exploring the pathogenesis of Sjögren's syndrome [0.03%]
DNA甲基化和转录组的联合研究：探索Sjögren综合征发病机制的新视角
Yanting Chi,Zhiming Qin,Jingjing Qiu et al.
Yanting Chi et al.
Background/purpose: Sjögren's syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration and formation of lymphoepithelial lesions (LEL) in exocrine glands, leading to secretory dysf...
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches [0.03%]
DNA甲基化研究中遗传谱系校正的优化：方法比较分析
Kira D Höffler,Seyma Katrinli,Matthew W Halvorsen et al.
Kira D Höffler et al.
Background: Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG...
Comparative Study
Epigenetics & chromatin. 2025 Oct 14;18(1):69. DOI:10.1186/s13072-025-00627-0 2025
Proteins driving liquid-liquid phase separation and histone modifications cooperatively associate with chromatin looping and transcriptional regulation [0.03%]
驱动液-液相分离的蛋白质和组蛋白修饰共同参与染色质环形成及转录调控
Xue Ji,Yumin Nie
Xue Ji
Background: Although liquid-liquid phase separation (LLPS) proteins are known to participate in genome organization and transcriptional regulation through the formation of biomolecular condensates, their functional interp...
Antagonistic histone post-translational modifications improve the fidelity of epigenetic inheritance - a Bayesian perspective [0.03%]
拮抗的组蛋白翻译后修饰提高了表观遗传继承的保真度-贝叶斯观点
B N Balakrishna Prabhu,Aditya Naman Soni,Sibi Raj B Pillai et al.
B N Balakrishna Prabhu et al.
Background: Histone Post-Translational Modifications (PTMs) are important epigenetic marks, whose specific pattern over the chromatin plays a critical role in turning the corresponding gene on/off. During DNA replication ...
Multigenerational temperature effects on paternal epigenetic inheritance in European sea bass [0.03%]
欧洲海鲈的多代温度效应及其父系表观遗传传递
Núria Sánchez-Baizán,François Allal,Marc Vandeputte et al.
Núria Sánchez-Baizán et al.
Environmental changes can induce epigenetic modifications, influencing gene expression, phenotype, and species adaptation. This study investigates how temperature affects genome-wide DNA methylation patterns, particularly in genes crucial f...
ING5: multifaceted roles beyond tumor suppression in cellular physiology and disease [0.03%]
ING5：超出肿瘤抑制作用的细胞生理和疾病中的多种角色
Jie Liao,Xiaohuan Zhang,Zhangyuwei Chen et al.
Jie Liao et al.
ING5, initially identified as a tumor-suppressor, serves as a chromatin regulator with a diverse and extensive range of biological functions. This review undertakes an in-depth exploration of the structural characteristics and domain organi...
Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation [0.03%]
鱼精蛋白在体细胞中的表达使染色质凝聚并干扰转录，而不改变DNA甲基化状态
Deepika Puri,Alexandra Bott,Monica Varona Baranda et al.
Deepika Puri et al.
Background: Protamines play a crucial role in nuclear condensation during spermiogenesis, a process associated with significant chromatin remodeling and replacement of histones. While much research has focused on the func...
Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency [0.03%]
组蛋白乙酰化稳态失调揭示转录稳健性的多层染色质调控机制
Vrinda Venu,Eric M Small,Cullen Roth et al.
Vrinda Venu et al.
Background: Epigenetic modifications, nucleosome occupancy, and three-dimensional chromatin architecture collectively create a multi-layered, highly interactive regulatory system for controlling genomic functionality. Dys...