Daphnia magna diapause-interrupted embryogenesis has changes in histone modifications at H3K9 [0.03%]
大型水蚤休眠中断胚胎发育过程中H3K9组蛋白修饰变化
Luxi Chen,Rocío Gómez,Frauke Brenne et al.
Luxi Chen et al.
As a key component of freshwater ecosystem, Daphnia survives environmental challenges by entering a state of developmental arrest known as diapause. Diapause is not simply a sudden halt in growth and development, but a genetically regulated...
DNA variants affecting chromatin structure are key to the genetic architecture of obsessive compulsive disorder [0.03%]
影响染色质结构的DNA变异是强迫症遗传结构的关键因素
Velda X Han,Shrujna Patel,Shekeeb S Mohammad et al.
Velda X Han et al.
Background: Obsessive Compulsive Disorder (OCD) affects 2 to 3% of the population and is marked by intrusive thoughts and repetitive behaviours. OCD is increasingly recognized as a polygenic disorder involving gene-enviro...
Interaction of serotonin transporter and TGFB1 facilitates histone serotonylation-mediated synaptic plasticity following environmental enrichment in stressed mouse Mus booduga [0.03%]
五羟色胺转运蛋白与TGFB1的互作通过环境富集促进应激小花鼠纹状体突触可塑性及相关组蛋白色氨酰化的修饰
Swamynathan Sowndharya,Koilmani Emmanuvel Rajan
Swamynathan Sowndharya
Physicochemical features of intrinsically disordered regions predict DNA-demethylation-promoting activity of transcription factors [0.03%]
转录因子的内在无序区域的理化特性可预测其促DNA去甲基化活性
Xian-Yang Qin,Yuta Sakamoto,Feifei Wei et al.
Xian-Yang Qin et al.
Background: Transcription factor (TF)-dependent DNA demethylation is associated with generation of specific DNA methylation profiles in normal cellular development and disease, although only a small fraction of TFs are kn...
Convergent DNA methylation abnormalities at enhancers and bivalent promoters in human growth disorders [0.03%]
人类生长障碍中增强子和二价启动子处的趋同DNA甲基化异常现象
Marie E S Wheeler,Yoshiko Takahashi,Jihye Lee et al.
Marie E S Wheeler et al.
Loss-of-function mutations in DNMT3A, a DNA methyltransferase, or NSD1, a histone methyltransferase, cause overgrowth syndromes. Conversely, disruption of the DNMT3A domain that binds NSD1-deposited H3K36 dimethylation (H3K36me2) results in...
Cooperation between architectural C2H2 proteins in CP190 recruitment to Drosophila regulatory elements [0.03%]
合作调控元件上C2H2类转录因子招募CP190蛋白至果蝇染色体上的作用机制研究
Oksana Maksimenko,Natalia Klimenko,Ghadeer Salloum et al.
Oksana Maksimenko et al.
Background: CTCF (CCCTC-binding factor) is the best-studied architectural protein that is highly conserved among animals, including Drosophila and mammals. In Drosophila, CTCF is involved in the organization of functional...
Correction: Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression [0.03%]
纠正：KAT2B介导的AIM2乙酰化通过抑制AKT / Wnt / β-catenin信号通路活化而抑制乳腺癌进展
Yaqiong Li,Lingcheng Wang,Wei Wanga et al.
Yaqiong Li et al.
Published Erratum
Epigenetics & chromatin. 2025 Dec 20;18(1):81. DOI:10.1186/s13072-025-00645-y 2025
Gain of function p53 mutant R273H confers distinct methylation profiles and consequent YAP/TAZ signaling mediated activation of partial or full EMT states to colon tumours [0.03%]
p53突变体R273H的获得性功能通过特定的甲基化模式导致结肠肿瘤中YAP / TAZ介导的部分或全部上皮间质转化激活状态
Harsha Rani,Seemadri Subhadarshini,Mohit Kumar Jolly et al.
Harsha Rani et al.
Background: Mutations in tumour suppressor p53 are frequently implied in aggressive progression and metastasis in colorectal cancer. But the distinct phenotypes exhibited by site-specific mutations of p53 are not well elu...
Research advances in epigenetic modifications and post-translational modifications in endothelial-mesenchymal transition [0.03%]
内皮-间质转化表观遗传修饰和翻译后修饰研究进展
Zhongjun Shen,Shuo Yang,Qian Zhang et al.
Zhongjun Shen et al.
Endothelial-mesenchymal transition (EndMT) is a biological process in which endothelial cells lose intercellular junctions and endothelial characteristics under specific pathophysiological stimuli and acquire mesenchymal traits. It plays a ...
Ye Liu,Yingjie Mi,Manru Song et al.
Ye Liu et al.
DNA methylation is a most heritable epigenetic modification. Being a major vegetable crop, pepper (Capsicum spp.) possesses an over 3 Gb genome populated with TEs. This indicates a rich reservoir of epigenetic regulatory mechanisms. However...