The linker histone chaperone Prothymosin α (PTMA) is essential for efficient DNA damage repair and the recruitment of PARP1 [0.03%]
链接组蛋白伴侣Prothymosin α（PTMA）对于有效DNA损伤修复和PARP1募集是必需的
Ciara A McKnight,Mary E Graichen,Eric M George et al.
Ciara A McKnight et al.
Background: Mammalian cells have numerous DNA repair pathways to repair lesions generated by replication errors, metabolism, and exogenous agents. Cells can sense and respond to DNA damage within seconds, suggesting that ...
Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function [0.03%]
解开凝聚素-染色质界面的奥秘：识别调节染色体结构和功能的蛋白质相互作用
Natalie L Rittenhouse,Riya Gohil,June E Arricastres et al.
Natalie L Rittenhouse et al.
Background: The evolutionarily conserved cohesin complex is a pleiotropic regulator of chromosome structure and function, participating in sister chromatid cohesion, transcriptional regulation of genes, DNA replication, a...
The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability [0.03%]
酿酒酵母ISW2染色质重塑复合物中WAC-downWAC结构域是一个对ISW2功能但非细胞活力必不可少的结构模块
Ashish Kumar Singh,Sabine Ines Grünert,Lena Pfaller et al.
Ashish Kumar Singh et al.
Background: ATP-dependent nucleosome remodeling complexes of the imitation switch (ISWI) family slide and space nucleosomes. The ISWI ATPase subunit forms obligate complexes with accessory subunits whose mechanistic roles...
DNMT3B promotes the progression of pheochromocytoma by mediating the hypermethylation of LRP1B promoter [0.03%]
DNA甲基化转移酶DNMT3B通过介导肾上腺素瘤中LRP1B启动子高甲基化促进疾病进展
Min Sun,Yanrong Ma,Jing Wan et al.
Min Sun et al.
Background: Pheochromocytoma (Pheo) represents a potential metastatic neuroendocrine tumor. As a tumor suppressor gene, LRP1B is involved in the regulation of tumor progression. However, the precise regulatory mechanism o...
LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy [0.03%]
LSD1诱导组蛋白H3K9去甲基化促进甲状腺相关性眼病的脂肪细胞生成
Yuyan Xu,Jing Hu,Yuhang Fan et al.
Yuyan Xu et al.
Background: Thyroid-associated ophthalmopathy (TAO) is an autoimmune orbital disease influenced by multiple factors, including genetic and immune factors. The enlargement of orbital fat tissues are mainly due to abnormal ...
Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression [0.03%]
KAT2B介导的AIM2乙酰化通过抑制AKT / Wnt / β-catenin信号通路激活乳腺癌的发展
Yaqiong Li,Lingcheng Wang,Wei Wei Wangb et al.
Yaqiong Li et al.
Background: The development of breast cancer is known to be greatly influenced by epigenetic changes. The impact of histone acetyltransferase KAT2B on AIM2 and AKT/Wnt/β-catenin signaling have not been studied yet. ...
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation [0.03%]
H3K27me3和PRC1-H2AK119ub通路在丧失H3K9甲基化之后协同维持异染色质和转录沉默
Kei Fukuda,Chikako Shimura,Yoichi Shinkai
Kei Fukuda
Background: Heterochromatin is a fundamental component of eukaryotic chromosome architecture, crucial for genome stability and cell type-specific gene regulation. In mammalian nuclei, heterochromatin forms condensed B com...
DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples [0.03%]
唾液样本表征严重RSV感染的婴儿DNA甲基化标志物
Sara Pischedda,Alberto Gómez-Carballa,Jacobo Pardo-Seco et al.
Sara Pischedda et al.
Background: Respiratory syncytial virus (RSV) poses significant morbidity and mortality risks in childhood, particularly for previously healthy infants admitted to hospitals lacking predisposing risk factors for severe di...
MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the FMR1 locus in fragile X syndrome or the FXN locus in Friedreich's ataxia [0.03%]
甲基化维持或弗里德赖希共济失调症中FXN位点的重复序列收缩无需MSH2参与
Jessalyn Grant-Bier,Kathryn Ruppert,Bruce Hayward et al.
Jessalyn Grant-Bier et al.
Background: Repeat-induced epigenetic changes are observed in many repeat expansion disorders (REDs). These changes result in transcriptional deficits and/or silencing of the associated gene. MSH2, a mismatch repair prote...
H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma [0.03%]
H3F3A K27M 突变通过调节染色质可及性独立于H3K27me3在弥漫内生性桥脑胶质瘤中驱动转录组向抑制方向发展
Suraj Bhattarai,Faruck L Hakkim,Charles A Day et al.
Suraj Bhattarai et al.
Background: Heterozygous histone H3.3K27M mutation is a primary oncogenic driver of Diffuse Midline Glioma (DMG). H3.3K27M inhibits the Polycomb Repressive Complex 2 (PRC2) methyltransferase activity, leading to global re...