The antineoplastic and therapeutic effects of quinoline compounds against ehrlich ascites carcinoma in mice [0.03%]
喹琳化合物的抗肿瘤和治疗小鼠厄里希腹水癌的效果
Rasha Fekry Zahran,Ghada Mohamed Rady,Adel Zaki El-Sonbati
Rasha Fekry Zahran
Aim: One of the preferred scaffolds, 8-hydroxyquinoline, has been investigated synthetically by functioning at various places by several groups in pursuit of medicinally significant compounds. This research's objective is...
Unveiling the potential of zingerone-1,2,3-triazole derivatives as dual anticancer and COX-2 inhibitor: design, synthesis, and biological assessments [0.03%]
一种新型双抗癌和COX-2抑制剂类姜辣素-1,2,3-三氮唑衍生物的设计、合成及评价研究
Mohammad Mahboob Alam,Nawaf I Alsenani,Ahmed A Elhenawy et al.
Mohammad Mahboob Alam et al.
Aim: Cyclooxygenase-2 (COX-2) is reported to be upregulated in many cancers that promote cancer growth and angiogenesis. Therefore, inhibiting COX-2 can inhibit cancer growth and advances its treatment. In the present wor...
Synergistic action of JNK activation and BChE inhibition: a novel anti- glioblastoma compound with neuroprotective profile [0.03%]
JNK活化和胆碱酯酶抑制的协同作用：一种具有神经营养作用的抗胶质母细胞瘤化合物
Ziyao Lu,Qinghong Liao,Yuetong Duan et al.
Ziyao Lu et al.
Objective: This study aims to investigate whether butyrylcholinesterase (BChE) inhibitor QY-54 can be used to treat glioblastoma (GBM) and exert a neuroprotective profile. ...
Pyrroloquinoline quinone scaffolds: centrality in anticancer drug design [0.03%]
吡咯喹啉醌支架：抗癌药物设计中的中心地位
Siuli Sen,Dipanjan Karati
Siuli Sen
The Pyrroloquinoline Quinone (PQQ) is a quinone molecule that is redox active and has important health consequences for people. Several preclinical studies reveal the anticancer property of PQQ molecule by different molecular pathways. but ...
PROTACs in 2025: from the laboratory concept to clinical breakthrough [0.03%]
PROTAC技术在2025年：从实验室理念到临床突破
Yan Xu,Xin-Yu Li,Jian Song et al.
Yan Xu et al.
Discovery of novel 2,4-diarylaminopyrimidine derivatives as FAK inhibitors with potent anti-cancer potency [0.03%]
一种具有潜在抗肿瘤活性的新型FAK抑制剂类2,4-二芳基氨基嘧啶衍生物的发现
Yu-Zheng Lv,Jian Song,Sai-Yang Zhang et al.
Yu-Zheng Lv et al.
Aim: To evaluate novel 2,4-diarylaminopyrimidine derivatives as FAK inhibitors for cancer therapy and investigate their antitumor activity and mechanism of action. ...
Synthesis of anticancer agents: molecular docking and ADME studies of new hydropyrimidine linked amide-pyridine derivatives [0.03%]
抗癌药物的合成：新的杂环化合物与分子对接及ADME性质研究
Rajendran Aarthi,Chin-King Looi,Chun-Wai Mai et al.
Rajendran Aarthi et al.
Aim: To develop novel hydropyrimidine linked amide-pyridine hybrids as anticancer agents. Materials and methods: An array of molecular ...
Mechanosynthesis and computational studies of new imidazole-based selenium adducts as potential anticancer agents against human prostate and cervical cancer [0.03%]
基于咪唑的硒化物合成及理论计算研究：一类新型抗癌前药分子的设计与发现
Ghazanfar Abbas,Tanveer Hussain Bokhari,Muhammad Adnan Iqbal et al.
Ghazanfar Abbas et al.
Aims: This study aimed to design and synthesize three new selenium adducts to evaluate their anticancer potential against human prostate cancer (PC3) and cervical cancer (HeLa) cell lines using MTT assays. ...
Design, synthesis, in silico, and biological evaluation of novel pyrazolopyrimidinone-based estrogen receptor inhibitors [0.03%]
新型吡唑并嘧啶酮雌激素受体抑制剂的设计、合成、计算机模拟及生物活性评价
Sara A Hesham,Mai I Shahin,Laila Ziko et al.
Sara A Hesham et al.
Aims: A series of pyrazolo pyrimidinone derivatives was designed and evaluated as estrogen inhibitors. Materials and methods: The newly...
Synthesis and biological profiling of novel quinoline-thiadiazole-thiazolone scaffolds as antimicrobial agents [0.03%]
一类新型的抗微生物剂喹啉-噻二唑-噻唑酮类衍生物的设计、合成及活性研究
Hetali A Modi,Dushyant V Pathak,Pooja D Suradiya et al.
Hetali A Modi et al.
Aims: The present study aimed to design and synthesize a series of quinoline-thiadiazole-thiazolone hybrid derivatives and evaluate their antibacterial and antifungal activities. ...