"Spiro-pyrrolizidine-benzyloxy hybrid as synergistic partner to doxorubicin cardio-safe breast cancer chemotherapy" [0.03%]
"作为协同剂的Spiro-吡咯里西啶-苄氧杂与阿霉素安全型乳腺癌化疗"
Uthirapathi Rajapandiyan,M Raj Kumar,H Manikandan et al.
Uthirapathi Rajapandiyan et al.
Purpose of objective: This study aims to develop novel spiro-pyrrolizidine-benzyloxy hybrids (RP1, RP2, and RP3) to reduce the dosage and mitigate the side effects of doxorubicin (DOX) while harnessing potential synergist...
Synthesis and evaluation of anticancer and anti-invasive properties of 3-aminowithaferin A and its imine congeners [0.03%]
3-氨基伪麻黄素A及其亚胺类似物的合成与抗癌抗侵袭性能评价
Shabir Ahmad Mir,Tanzeeba Amin,Gulzar Hussain et al.
Shabir Ahmad Mir et al.
Aim: Synthesisof 3-aminowithaferin A and its imine congeners to identify promising lead molecules for future development as anti-cancer agents. Materials ...
New thiosemicarbazones: synthesis, structural characterization, in vitro, and in silico evaluation of antiproliferative effects [0.03%]
新型噻二唑酮的合成、结构表征及其体外和计算机辅助抗增殖活性评估
Hanife Ardahanli,Yavuz Derіn,Raşit Fikret Yilmaz et al.
Hanife Ardahanli et al.
Aims: To design, synthesize, and characterize N-(4-bromophenyl)-2-(substituted fluorobenzylidene)hydrazine-1-carbothioamides (II-IV) and evaluate their in vitro cytotoxicity against DLD-1 and MDA-MB-231 cells, supported b...
Recent advances in the design and development of small-molecule MMP-2 inhibitors [0.03%]
近年来低分子体重构酶-2抑制剂的设计与开发取得的进展
Ishita Biswas,Jigme Sangay Dorjay Tamang,Subha Mondal et al.
Ishita Biswas et al.
MMP-2 is crucial for ECM remodeling and embryonic development. MMP-2 is a key biomolecular target for its strong association with cancer progression, metastasis, and angiogenesis. Again, the implication of MMP-2 in other diseases is well-es...
Consecutive double chiral-switches strategy. ADHD methylphenidate drugs: from two racemates via racemate to enantiomer [0.03%]
连续双手性切换策略。注意缺陷多动障碍（ADHD）的甲基苯丙胺药物：从两个消旋体通过一个消旋体到对映体
Israel Agranat,Ilaria D&#x;Acquarica
Israel Agranat
The Perspective presents the strategy of double chiral switches of drugs, illustrating the scenario of consecutive double chiral switches of methylphenidate. The two chirality centers of methylphenidate hydrochloride give rise to four stere...
Zinc and copper metallodrugs: a 20-year perspective on therapeutic strategies and future directions [0.03%]
锌和铜金属药物：治疗策略的二十年回顾及未来展望
Carla Peron,Sidnei Moura
Carla Peron
This review explores the use of metallodrugs, compounds formed by coordinating metals with organic molecules, as a promising strategy to enhance therapeutic efficacy and address the limitations of conventional drugs. Essential metals, such ...
Bianca Stiller,Sonja Hager,Nenad R Filipović et al.
Bianca Stiller et al.
Design and evaluation of 2-(4-((2-(2-((2,6-dichloro-3-methylphenyl)amino)benzoyl)hydrazineylidene)methyl)phenoxy)acetic acid as a dual anti-inflammatory and anti-diabetic agent [0.03%]
设计和评估2-（4-（（2-（2-（（2,6-二氯-3-甲基苯基）氨基）苯甲酰基）肼基亚甲基）甲基）苯氧乙酸作为双重抗炎和抗糖尿病药物
Mohamed K Elgohary,Mahmoud S Elkotamy,Mahmoud Abdelrahman Alkabbani et al.
Mohamed K Elgohary et al.
Aims: This study aimed to design, synthesize, and evaluate a novel meclofenamic acid derivative (7) for its potential as a dual-target therapeutic agent with anti-inflammatory, antidiabetic, antioxidant, and anticancer ac...
Design and synthesis of novel N-phenyl-4-pyrimidine-diamine BCL6 inhibitors with anti-tumor activities [0.03%]
一类新型N-(芳代)-4-嘧啶二胺类BCL6抑制剂的抗肿瘤活性及其作用机制研究
Yan Li,Yajing Xing,Dongxia Huang et al.
Yan Li et al.
Aim: To develop potent B cell lymphoma 6 (BCL6) inhibitors, novel N-phenyl-4-pyrimidine-diamine analogs were designed and synthesized via structure-based and computer-aided drug design. ...
Anti-alkaline phosphatases (ALP) potentials of potent 4-aminobenzenesulfonamide derivatives against Naja oxiana venom [0.03%]
四种4-氨基苯磺酰胺衍生物对黑眉蝮(Naja oxiana)蛇毒碱性磷酸酶的抑制作用研究
Saqib Khan,Muhammad Yaqoob,Muhammad H H B Asad et al.
Saqib Khan et al.
Aim: Naja oxiana venom-induced alkaline phosphatase (ALP) enzyme has been documented for its detrimental effects post envenomation in the victims. Therefore, the present study was designed to evaluate the effectiveness of...