Synthesis of novel thiazole derivatives linked benzonitrile moiety as potent antimicrobial agents [0.03%]
一类新型噻唑并苯腈衍生物的合成及其抗菌活性研究
Mariam A Al-Sheikh,Thoraya A Farghaly
Mariam A Al-Sheikh
Aim: This study aims to design a new series of thiazoles by combining a thiazole core with a benzonitrile moiety via a suitable linker. Additionally, a hydrazone linker was employed to enhance molecular flexibility and fa...
Chalcone-indole hybrid scaffolds as promising anticancer drug candidates: a mini-review [0.03%]
作为有前景的抗肿瘤药物候选物的查耳酮-吲哚杂合骨架：综述
Yafei Zhuang,Yanjing Cheng,Danchen Zhao et al.
Yafei Zhuang et al.
Cancer treatment is hampered by severe systemic side effects, poor tumor selectivity, and multidrug resistance (MDR). Molecular hybridization integrates chalcone and indole, two privileged antitumor pharmacophores, into one scaffold to gene...
Progress and challenges in the design and development of selective KRAS G12D-targeted drug discovery: inhibitors, degraders and emerging therapeutic strategies [0.03%]
选择性KRAS G12D靶向药物设计和开发的进展与挑战：抑制剂、降解剂及新兴治疗策略
Eunhye Jeon,Jaewon Song,Taebo Sim
Eunhye Jeon
KRAS is one of the most frequently mutated oncogenes in human cancers, with KRAS G12D representing the predominant mutation in pancreatic ductal adenocarcinoma and a major driver of colorectal and lung cancers. Although KRAS was long consid...
Design, synthesis, and biological evaluation of imidazole-triazole hybrids as dual antimicrobial and antioxidant agents: experimental and in silico studies [0.03%]
咪唑-三氮唑衍生物的合成及生物活性研究：实验与计算模拟相结合的方法发现具有抗菌和抗氧化活性的杂环化合物
Ritika Chouhan,Vikas Verma,Sonia Rohilla et al.
Ritika Chouhan et al.
Background: Considering the growing challenge of antimicrobial resistance, novel imidazole-triazole hybrids were synthesized as promising antimicrobial and antioxidant candidates based on the pharmacological relevance of ...
Chromanone and chromone scaffolds in cancer and metabolic disorders: advances in synthesis, SAR, and developability (2020-2026) [0.03%]
关于癌症和代谢障碍的色酮骨架的研究进展（2020-2026）
Manisha Nidhar,Muhammad Afzal,Gaurav Gupta et al.
Manisha Nidhar et al.
Chromanone and chromone are related benzopyran-based scaffolds that offer multiple opportunities for structural modification and medicinal chemistry. This review summarizes studies published from 2020 to 2026 on the synthesis, structure-act...
Design and development of 2,7-disubstituted 6-methoxyquinazolin-4 (3 H)-ones as potential anti-cancer agents possibly through downregulation of Wnt/β-catenin/TCF4 signaling pathway [0.03%]
设计和开发2,7-取代的6-甲氧基喹唑啉-4(3H)-酮作为潜在的抗肿瘤化合物并通过下调Wnt/β-连环蛋白/TCF4信号通路发挥作用
Prashant R Murumkar,Kaushik Neogi,Premlal Meher et al.
Prashant R Murumkar et al.
Aim: A novel series of 2,7-disubstituted 6-methoxyquinazolin-4(3H)-one derivatives were designed, synthesized, and evaluated for in-vitro anti-cancer potential. ...
Synthesis of polyhydroquinoline derivatives as potent antidiabetic and antioxidant agents: in vitro biological activities and computational studies [0.03%]
高效降糖抗氧化多氢喹啉衍生物的合成及其体外生物活性与计算研究
Sultan Muhammad,Abdul Latif,Aftab Alam et al.
Sultan Muhammad et al.
Aims: Diabetes mellitus (DM) is a severe metabolic disease characterized by increased blood glucose levels due to reduced insulin action or secretion. This study aimed to synthesize new polyhydroquinoline (PHQ)-based acyl...
Rational drug design for Alzheimer's disease: from approved therapies to next-generation clinical candidates and AI-guided innovation [0.03%]
阿尔茨海默病的合理药物设计：从获批疗法到下一代临床候选药物及人工智能引导的创新
Sana Saffour,Turgut Seckin Gul,Halise Inci Gul
Sana Saffour
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by multifactorial pathology, including amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation, and synaptic dysfunction....
Asymmetric benzazole derivatives as dual antibiofilm and anti-wall teichoic acid agents against Staphylococcus aureus [0.03%]
具有抗菌斑和抗壁-teichoic酸作用的不对称苯并唑衍生物可对抗金黄色葡萄球菌
Mine Buga Aktekin,Zehra Oksuz,Mehmet Abdullah Alagoz et al.
Mine Buga Aktekin et al.
Aims: Antibiotic-resistant bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA), have renewed interest in antivirulence strategies. This study aimed to design, synthesize, and evaluate asymmetric di‑...
Latest developments in small molecule inhibitors of cysteine protease B as antileishmanial drugs [0.03%]
半胱氨酸蛋白酶B的小分子抑制剂作为抗利什曼病药物的最新进展
Karla Joane da Silva Menezes,Sonaly Lima Albino,João Vitor Vieira da Silva et al.
Karla Joane da Silva Menezes et al.
Leishmaniasis is a neglected tropical disease, transmitted by the bite of infected female sandflies and affecting the poor population. Current pharmacotherapy has remained largely unchanged for decades, and there are parasitic strains resis...