Rational drug design for Alzheimer's disease: from approved therapies to next-generation clinical candidates and AI-guided innovation [0.03%]
阿尔茨海默病的合理药物设计：从获批疗法到下一代临床候选药物及人工智能引导的创新
Sana Saffour,Turgut Seckin Gul,Halise Inci Gul
Sana Saffour
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by multifactorial pathology, including amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation, and synaptic dysfunction....
Asymmetric benzazole derivatives as dual antibiofilm and anti-wall teichoic acid agents against Staphylococcus aureus [0.03%]
具有抗菌斑和抗壁-teichoic酸作用的不对称苯并唑衍生物可对抗金黄色葡萄球菌
Mine Buga Aktekin,Zehra Oksuz,Mehmet Abdullah Alagoz et al.
Mine Buga Aktekin et al.
Aims: Antibiotic-resistant bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA), have renewed interest in antivirulence strategies. This study aimed to design, synthesize, and evaluate asymmetric di‑...
Latest developments in small molecule inhibitors of cysteine protease B as antileishmanial drugs [0.03%]
半胱氨酸蛋白酶B的小分子抑制剂作为抗利什曼病药物的最新进展
Karla Joane da Silva Menezes,Sonaly Lima Albino,João Vitor Vieira da Silva et al.
Karla Joane da Silva Menezes et al.
Leishmaniasis is a neglected tropical disease, transmitted by the bite of infected female sandflies and affecting the poor population. Current pharmacotherapy has remained largely unchanged for decades, and there are parasitic strains resis...
Design, synthesis and dual anticancer and antibacterial evaluation of novel 1,3,4-oxadiazole-2-thiol derivatives targeting EGFR and DNA Gyrase B: integrated docking, DFT and ADMET studies [0.03%]
设计、合成并结合EGFR和DNA Gyrase B靶点的新型1,3,4-氧硫杂环戊二烯-2-硫醇衍生物的双抗肿瘤及抗菌评价：整合对接、DFT以及ADMET研究
Ila M Ram,Jay B Maheta,Darshna K Lakhnotra et al.
Ila M Ram et al.
Novel 1,3,4-oxadiazole-2-thiol derivatives (8a-j) were synthesized via multistep reactions and characterized using IR, 1H NMR, and 13C NMR spectroscopy. The compounds were evaluated for dual anticancer and antibacterial activities through c...
Thomas Scattolin
Thomas Scattolin
From design to functionality of ionic-liquid-related salts: DNA titration, antioxidants, and anticancer activities [0.03%]
从设计到功能性相关的离子液体盐：DNA滴定，抗氧化和抗癌活性
Salim Ali,Ming-Fa Hsieh,Zheng-Yuan Su et al.
Salim Ali et al.
Aims: To develop effective functional ionic-liquid-related salts (ILRSs) as future anticancer drugs. Materials and methods: Twelve imid...
Isatin as a privileged scaffold for kinase inhibition: recent advances in anti-cancer research [0.03%]
异丁素作为激酶抑制的优选骨架在抗癌研究中的最新进展
Alia Mushtaq,Azmat Ullah Khan,Akasha Maqbool et al.
Alia Mushtaq et al.
Protein kinases are key therapeutic targets in anticancer drug discovery due to their central roles in regulating cell proliferation, survival, and signaling pathways. Among diverse heterocyclic scaffolds, isatin (indole-2,3-dione) has emer...
Integrated in vitro and in silico evaluation of adamantane-1,2,3-triazole hybrids as potential α-glucosidase inhibitors [0.03%]
三唑金刚烷杂化物作为潜在α-葡萄糖苷酶抑制剂的体内外综合评价
Aman Ragshaniya,Vivek Asati,Jayant Sindhu et al.
Aman Ragshaniya et al.
Aims: To find for lead compounds, efficiently defeating diabetes mellitus, prompted us to the synthesis of a new library of adamantane‑appended 1,2,3-triazole hybrid conjugates (AT1-AT18). ...
Synthesis of thiosemicarbazone derivatives of thiophene-2-carboxylic acid as potent urease inhibitors: in vitro evaluation, molecular docking, and density functional theory analysis [0.03%]
基于噻吩-2-羧酸的噻唑乙二胺衍生物作为尿素酶抑制剂的研究：体外评价，分子对接和密度泛函理论分析
Wisal Khan,Laiba,Imtiaz Ahmad et al.
Wisal Khan et al.
Aims: To synthesize and evaluate a series of thiosemicarbazone derivatives (2a-2g) incorporating thiophene-2-carboxylic acid as urease inhibitors. Materia...
Unlocking new antimicrobial leads in the last decade: exploring quinolin-2-one based hybrids' synthesis, action, SAR, and challenges in tackling antimicrobial resistance [0.03%]
十年来抗菌新先导的发现：基于喹啉-2-酮衍生物的合成、作用机制、构效关系及其对抗微生物耐药性挑战的研究探索
Mahmoud Alaaeldin Khattab,Mai I Shahin,Azza T Taher et al.
Mahmoud Alaaeldin Khattab et al.
The rapid emergence of antimicrobial resistance (AMR) posed a major global health threat and created an urgent need for new broad-spectrum antimicrobial agents. The quinolin-2-one scaffold emerged as a privileged structural motif in medicin...