Importance of five membered heterocyclic compounds in treatment of chronic myeloid leukemia by targeting various pathways [0.03%]
五元杂环化合物治疗慢性髓系白血病的多靶点研究意义
Raju Ninave,Aman Mourya,Navnit Prajapati
Raju Ninave
Chronic myeloid leukemia (CML) is a clonal hematopoietic malignancy characterized by the presence of the Philadelphia chromosome, which generates the constitutively active BCR::ABL1 tyrosine kinase, driving uncontrolled myeloid proliferatio...
Design and synthesis of novel antibacterial hybrids combining quinoline and thiazole moieties [0.03%]
结合喹啉和噻唑结构的新型抗菌杂环化合物的设计与合成
Mostafa M A Aref,Sami A Al-Hussain,Alyaa S Abdel Halim et al.
Mostafa M A Aref et al.
Aim: The emergence of bacterial resistance underlines the urgent need for antibacterial agents with novel structures and mechanisms. We designed quinoline-thiazole hybrids by combining two privileged pharmacophores with e...
Molecular strategies for heterocyclic frameworks in antidiabetic drug discovery: a vision from 2020-2024 [0.03%]
抗糖尿病药物发现中的杂环框架分子策略：2020-2024年展望
Sumit Tahlan,Sucheta Singh,Hrithik Dey et al.
Sumit Tahlan et al.
Diabetes mellitus represents a global health crisis requiring innovative therapeutic strategies beyond traditional treatments. This comprehensive review analyzes heterocyclic frameworks developed between 2020-2024 for antidiabetic drug disc...
Design, synthesis, and antidiabetic activity of new furan-clubbed 1,2,3-triazole derivatives as α-glucosidase inhibitors [0.03%]
新型呋喃环取代1,2,3-三唑化合物的设计、合成及α-糖苷酶抑制和降血糖活性研究
Priya Devi,Subhadip Maity,Aastha Singh et al.
Priya Devi et al.
Aim: The study aims to design, synthesize, and evaluate novel furan-clubbed 1,2,3-triazole derivatives as potential α-glucosidase inhibitors for the management of diabetes mellitus. ...
Integrated computational and biological assessment of novel piperazine and piperidine-substituted 1,2,4-oxadiazoles for lung cancer therapy [0.03%]
计算与生物评估新型哌嗪和哌啶取代的1,2,4-恶二唑类化合物用于肺癌治疗
Deepak Kumar,Mukesh Jangir,Arti Chaurasia
Deepak Kumar
Aims: To design and synthesize a novel series of piperazine- and piperidine-substituted 1,2,4-oxadiazole derivatives and evaluate their anticancer potential, with particular interest in possible interaction with the epide...
Chrysin and derivatives: therapeutic potential in the patent landscape [0.03%]
专利文献中的黄酮醇类化合物(chrysin及其衍生物)的治疗潜力研究现状
Silvia Vitoria Silva Cezar,Alcimary Bispo Santos,Naira Nice Dos Santos et al.
Silvia Vitoria Silva Cezar et al.
Natural compounds represent approximately 35% of the pharmaceutical market, gaining prominence in the treatment of various diseases. Among them is chrysin, a flavonoid with notable antimicrobial and immunomodulatory activities. However, its...
Zinc chloride-catalyzed synthesis of indole-based α-aminophosphonates with potent antimicrobial and anticancer activities: in vitro and in silico evaluation [0.03%]
以锌氯化物催化合成具有抗菌和抗肿瘤活性的吲哚基α-氨基磷onic酸酯：体外及基于计算机辅助的评价
Ghadah Aljohani
Ghadah Aljohani
Aim: This study aimed to synthesize new α-aminophosphonate derivatives based on 2-(thiophen-2-yl)-1H-indole-3-carbaldehyde and evaluate their anticancer, antimicrobial, and drug-likeness properties supported by molecular...
Novel pyrimidine-triazole conjugates for targeted inhibition of EGFR: synthesis and biological evaluation [0.03%]
新型嘧啶-三氮唑共轭物靶向抑制表皮生长因子受体：合成与生物活性评估
Subhadip Maity,Priya Devi,Aastha Singh et al.
Subhadip Maity et al.
Aim: To design, synthesize, and evaluate novel pyrimidine-triazole derivatives as epidermal growth factor receptor (EGFR) inhibitors for anticancer activity. ...
Manish Kumar,Shivangi Garg,Łukasz Berlicki
Manish Kumar
The discovery of enzyme inhibitors has sparked global efforts to develop new therapeutics. In this regard, ebselen, an organoselenium compound, has been recognized with promising broad biological and enzyme inhibition activities of thiol-co...
Recent advances in the design and development of small molecules against Lpx enzymes for mitigating Pseudomonas aeruginosa infections [0.03%]
近年来设计和开发作用于Lpx酶以缓解铜绿假单胞菌感染的小分子研究进展
Supriyo Saha,Nikita Thapliyal,Muskan Singh et al.
Supriyo Saha et al.
The emergence of infections caused by the gram-negative bacterium Pseudomonas aeruginosa is widely recognized as a major cause of nosocomial infections and antimicrobial resistance. In gram-negative bacteria such as P. aeruginosa, Lipid A h...