Ultrasound-assisted 1,2,4-triazole Schiff bases: synthesis, characterization, docking, and dual inhibition of urease and α-glucosidase [0.03%]
超声辅助1,2,4-三唑希夫碱的合成、表征、对接及尿酶和α-葡萄糖苷酶双抑制作用研究
Ergün Gültekin
Ergün Gültekin
Aim: This study aimed to design and synthesize novel 3-pentyl-substituted 1,2,4-triazole-5-thione Schiff base derivatives and evaluate their dual inhibitory potential against urease and α-glucosidase enzymes. ...
Targeting traumatic brain injury via novel tetrahydrocarbazole derivatives: in silico design, synthesis, and in vitro evaluation of dual NADPH oxidase 2 and 4 inhibitors [0.03%]
针对创伤性脑损伤的新型四氢 карбазол 衍生物的设计、合成及体外评价：一种新的NOX2和NOX4双重抑制剂
Akashdeep Singh Pathania,Kavita Badhai,Nirmal Singh et al.
Akashdeep Singh Pathania et al.
Aim: The upregulation of NADPH oxidase 2 (NOX2) and NADPH oxidase 4 (NOX4) contributes to traumatic brain injury (TBI)-induced oxidative stress and neurodegeneration. This study designed, synthesized, and evaluated 19 sul...
Tailored pyrazolone-oxadiazole frameworks: synthetic execution, functional enzyme studies, and comprehensive docking-DFT-based antidiabetic investigation [0.03%]
基于吡唑酮-噁二唑框架的抗糖尿病药物研究
Tayyiaba Iqbal,Mohamed A Habib,Shoaib Khan et al.
Tayyiaba Iqbal et al.
Aim: This study aimed to design, synthesize, and biologically evaluate a novel series of pyrazolone-derived oxadiazole Schiff base derivatives as potential anti-diabetic agents. ...
Synthesis of 2, 4-disubstituted-1 H-benzo[ b][1,4]diazepine derivatives as promising anticancer agents [0.03%]
合成2,4-取代的-1H-苯并[б][1,4]二氮杂卓衍生物作为有前景的抗肿瘤制剂
Farid M Sroor,May A El-Manawaty,Wagdy K B Khalil et al.
Farid M Sroor et al.
Aims: A novel series of 1H-benzo[b][1,4]diazepine derivatives bearing different substitutions at positions 2 and 4 was designed, synthesized, and tested as anticancer agents. ...
A review of recent efforts directed toward the discovery of small molecule modulators of KCNT1 channels [0.03%]
调控KCNT1通道的的小分子调节物的最新研究进展综述
Paul K Peprah,Kyle A Emmitte
Paul K Peprah
KCNT1 channels are important targets in a variety of conditions, especially childhood epilepsies associated with activating mutations. Growing interest in this target has driven the discovery of KCNT1 channel modulators to serve as probes a...
Design, synthesis, and biological evaluation of novel coumarine-1,2,3-triazole hybrids as dual DNA gyrase/superoxide dismutase inhibitors: molecular docking, DFT, and ADMET investigations [0.03%]
新型香豆素-1,2,3-三唑杂化物作为双DNA回旋酶/超氧化物歧化酶抑制剂的设计、合成及生物活性评价：分子对接、DFT及ADMET研究
Gaurav B Patel,Yogesh O Bhola,Piyush V Dholaria et al.
Gaurav B Patel et al.
A series of eight novel coumarin-1,2,3-triazole hybrid derivatives (6a-h) were synthesized and evaluated for their antimicrobial and antioxidant potentials through in vitro and in silico approaches. Molecular docking studies against DNA gyr...
Therapeutic potential of sulfonate-based hydrazide hydrazones in neurodegenerative diseases: SAR insights and molecular modeling studies [0.03%]
基于磺酸的腙类化合物在神经退行性疾病治疗中的潜力：结构活性关系和分子建模研究
Bedriye Seda Kurşun Aktar,Ayşegül Karaküçük-İyidoğan,Gizem Tatar Yılmaz et al.
Bedriye Seda Kurşun Aktar et al.
Aims: Cholinesterase inhibitors represent an important therapeutic strategy in combating Alzheimer's disease. Material and methods: The...
Quinoline-piperazine molecular hybrids as potential antimalarial agents [0.03%]
喹啉-哌嗪分子杂环并用作抗疟药的潜力研究
Amisha Punmiya,Amisha Vora
Amisha Punmiya
Malaria is one of the most prevalent infectious diseases worldwide, posing a significant threat in the malaria-endemic areas. The rapid emergence of Plasmodium strains resistant to the existing antimalarial drugs underscores the necessity f...
Cyclization, amino acid coupling, docking-based virtual screening and SAR: showing a strategy of the structural modification for salvianic acid A [0.03%]
环化、氨基酸偶联、基于对接的虚拟筛选及构效关系研究：丹参素结构修饰策略探讨
Jianhui Wu,Xiaoyi Zhang,Wenshuo An et al.
Jianhui Wu et al.
Aim: Providing diverse modification remains to be a strategy for salvianic acid A. Materials and methods: Based on the docking virtual ...
Design, synthesis and biological evaluation of a 4,6-di(aziridin-1-yl)-1,3,5-triazine-benzimidazole hybrid as a potential dual-targeting anticancer agent [0.03%]
设计、合成及生物活性评估一种新型的4,6-二氮杂环丁基-1,3,5-三嗪-苯并咪唑类衍生物：一种潜在的抗肿瘤药物候选物
Ivan S Chernov,Alexandra V Protas,Elena А Popova et al.
Ivan S Chernov et al.
Aims: This study aimed to develop a novel aziridine-1,3,5-triazine derivative combining DNA-alkylating aziridine rings with a benzimidazole-containing fragment associated with PARP-related chemotypes. ...