Therapeutic potential of spirocyclopropyl oxindoles: latest developments in drug discovery [0.03%]
Spirocyclopropyl氧化吲哚的治疗潜力：药物发现的最新进展
Sowmya Dastari,Nagula Shankaraiah
Sowmya Dastari
In the recent past, spirooxindoles have been evolved as captivating structural architectures for the medicinal chemists, owing to their diverse biological activities. In particular, the development of spirocyclopropyl oxindole heterocycles ...
Synthesis, characterization, in-silico, and in-vitro evaluation of 4-amino- N-(4-aminophenyl)benzene sulfonamide derivatives against Naja oxiana 5'-nucleotidases (5'-NT) enzyme [0.03%]
4-氨基-N-(4-氨基苯基)苯磺酰胺衍生物的合成、表征以及对阿夫乐迪 Cobra 5'-核苷酸酶（5'-NT）的体内和体外评价研究
Amina Noor Ul Huda,Bibi Fatima Nayyab,Muhammad Hassham Hassan Bin Asad et al.
Amina Noor Ul Huda et al.
Aim: 5'-Nucleotidase (5'-NT) enzyme has been reported for its detrimental effects post-Naja oxiana (N. oxiana) envenomation via generation of adenosine moiety. Therefore, the present study was designed to evaluate anti-5'...
Design, synthesis, and in vitro evaluation of novel longifolene derivatives for Alzheimer's disease [0.03%]
新设计姜黄烯衍生物治疗阿尔茨海默病及其体外活性评价
Ami Thakkar,RajaSekhar Reddy Alavala,Ginpreet Kaur et al.
Ami Thakkar et al.
Aim: The study combines computational and experimental approaches to provide structural and functional features of novel ligands, emphasizing their promising role as canditates for Alzheimer's disease (AD) drug developmen...
Neurotransmitter & precursor to the neurotransmitter linked lawsone derivatives: design, synthesis, molecular docking, and evaluation of antidiabetic potential [0.03%]
胆碱及乙酰胆碱前体联桥 Lawsone 衍生物的设计、合成、分子对接及其抗糖尿病活性评价
S Monica,P R Kavitha Rani,S Hari Prasad
S Monica
Aims: Type 2 diabetes mellitus (T2DM) is an increasingly prevalent worldwide health problem, and new antidiabetic agents are needed to address the limitations of current therapies. The research aims to create and assess h...
Novel (+)-usnic acid derivatives, computational studies and biological evaluation as neuroprotective agents [0.03%]
新型（+）-松奴酸衍生物的计算研究及其神经保护活性评估
Gautam Kumar,Rahul Kumar,Tanish et al.
Gautam Kumar et al.
Aims: This study involves the semi-synthetic modification of (+)-usnic acid and the evaluation of the synthesized compounds for neuroprotective effects in scopolamine-injured C6 glial cells. ...
Development of new thiosemicarbazones with strong α-glucosidase and antioxidant action [0.03%]
一类新型具有强α-葡萄糖苷酶和抗氧化活性的噻二唑并半卡箱化合物的发展
Memona Kamal,Nastaran Sadeghian,Feyzi Sinan Tokalı et al.
Memona Kamal et al.
Aim: This study aimed to synthesize a new series of thiosemicarbazone derivatives (4a-r) as multifunctional antidiabetic candidates with dual α-glucosidase (α-Glu) inhibitory and antioxidant activities to address both h...
Developments in the design and therapeutic applications of GSK3β inhibitors [0.03%]
GSK3β抑制剂的设计及应用进展
Safa Daoud,Mutasem Taha
Safa Daoud
Glycogen synthase kinase-3β (GSK3β) has emerged as one of the most thoroughly validated therapeutic targets in modern drug discovery, with dysregulation implicated in neurodegenerative diseases, metabolic disorders, cancer, psychiatric co...
Advances in the clinical potential of pyrimidine analogues as tubulin inhibitors in oncology [0.03%]
嘧啶类似物作为抗肿瘤微管抑制剂的临床潜力进展
Menglin Luo,Shuwang Jiang,Yufeng Ma et al.
Menglin Luo et al.
Tubulin represents a highly promising anticancer target and several inhibitors have been approved for cancer therapy. However, drug resistance and dose-dependent toxicity have limited clinical application. Recently, some novel pyrimidine de...
Small molecule dual inhibitors of HDAC6/HSP90 as potential anticancer therapeutics: an overview of design rationality and structure activity relationships [0.03%]
HDAC6/HSP90 小分子双重抑制剂作为抗癌药物的潜力：设计原理和结构活性关系概述
Sandipan Dash,Sheik Shehensha,Arghya Kusum Dhar et al.
Sandipan Dash et al.
The inherent limitations of single-target cancer therapies, including drug resistance, toxicity, and inadequate efficacy against heterogeneous tumors, have catalyzed the strategic shift toward multi-targeted agents. The synergistic interpla...
New chromene derivatives as promising VEGFR-2 inhibitors: combined experimental, DFT, and molecular dynamics approaches [0.03%]
具有前景的VEGFR-2抑制剂类黄酮衍生物：结合实验、DFT及分子动力学研究
Eslam B Elkaeed,Hazem Elkady,Walid E Elgammal et al.
Eslam B Elkaeed et al.
Aims: This study aimed to design and synthesize a novel series of chromene derivatives as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with anticancer activity. ...