Hybridization of isatin and benzoxazolinone via a diethyl spacer: a new scaffold for breast cancer drug discovery [0.03%]
通过二乙基间隔基杂化异挫和苯并恶唑酮：用于乳腺癌药物发现的新骨架
Garima Chauhan,Sahil Kumar,Dharam Pal Pathak et al.
Garima Chauhan et al.
Aim: The present study mainly focused to design and synthesized isatin and benzoxazolinone hybrids via a diethyl linker and evaluate their anti-breast cancer activities. ...
Pyran-core small molecules inhibit basal-like triple-negative breast cancer via proteasome activity [0.03%]
吡咯烷核心小分子通过蛋白酶体活性抑制基底样三阴性乳腺癌
Khor Poh Yen,Johnson Stanslas,Mock Phooi Yan et al.
Khor Poh Yen et al.
This study investigates the nonsymmetrical pentanoid derivative 5e as a selective anticancer agent against basal-like triple-negative breast cancer (TNBC). The pyran-core derivative 5e demonstrated significant selectivity, effectively suppr...
Benzimidazole derived hydrazone Schiff bases as potent cholinesterase inhibitors: synthesis, in vitro and in silico approaches [0.03%]
基于苯并咪唑的杂芳酰腙类化合物作为乙酰胆碱酯酶抑制剂的研究：体外及分子模拟研究
Abdul Shakoor,Ahmed A Elhenawy,Aftab Alam et al.
Abdul Shakoor et al.
Aims: The current study aimed to synthesize and evaluate benzimidazole Schiff bases as dual acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). ...
A comprehensive exploration of the structure-activity relationships, multitarget strategies, and therapeutic mechanisms of triazole scaffolds in Alzheimer's disease [0.03%]
三氮唑支架在阿尔茨海默病结构活性关系、多靶标策略和治疗机制的全面探索
Aafreen Malvankar,Mahesh Raut,Sushil Kumar Singh et al.
Aafreen Malvankar et al.
The deposition of the Aβ peptide extracellularly as diffused and neuritic plaques and intracellular hyperphosphorylated tau (p-tau) protein as neurofibrillary tangles (NFTs) are the key pathological changes observed in the progression of A...
Novel nicotinic hydrazone derivatives as multitarget carbonic anhydrase and acetylcholinesterase inhibitors with anticancer potential: synthesis, biological evaluation and molecular docking studies [0.03%]
新型烟碱杂芳酰腙衍生物作为多靶点碳酸酐酶和乙酰胆碱酯酶抑制剂的抗肿瘤作用：合成，生物活性评价及分子对接研究
Osman Nuri Aslan,Işıl Nihan Korkmaz,Fatma Necmiye Kacı et al.
Osman Nuri Aslan et al.
Aims: This study aims to design and synthesize novel nicotinic hydrazone derivatives and evaluate their multitarget biological activities, including enzyme inhibition and anticancer potential. ...
Design and synthesis of pyrazole-heteroaryl arylhydrazone schiff base hybrids with antimicrobial and docking evaluation [0.03%]
抗菌活性吡唑-杂芳酰腙席夫碱衍生物的设计合成与分子对接研究
Asmaa L Alanzy,Mohamed N El-Bayaa,Dania Alweet et al.
Asmaa L Alanzy et al.
Background: The alarming rise of multidrug-resistant microbial infections underscores the urgent need for novel antimicrobial agents. Aim: ...
Antiviral nucleoside mimics: the development and future perspective of Molnupiravir [0.03%]
抗病毒核苷类药物莫纳皮拉韦的研发及其未来展望
Ahmed Khalil
Ahmed Khalil
In 2021, the U.S. Food and Drug Administration (FDA) authorized the oral prodrug molnupiravir, the β-D-N4-hydroxycytidine precursor, for emergency use as an antiviral agent against SARS-CoV-2. Molnupiravir (MK-4482, EIDD-2801) was original...
Design and synthesis of new curcumin analogues as hepatoprotectives and antioxidants in liver dysfunction through caspase-3 regulation [0.03%]
设计并合成新型姜黄素衍生物以调节肝功能障碍中的半胱天冬酶-3从而保护肝脏和抗氧化的新方法及成果
Nashwa Hafez Zaher,Mohamed Ismail Mostafa,Marwa Galal El-Gazzar
Nashwa Hafez Zaher
Background: Chronic liver disease is a progressive, worldwide health crisis, with its incidence and prevalence increasing annually. It causes progressive liver injury and ultimately fibrosis. Globally, it is responsible f...
Novel coumarin-1,2,3-triazole-isatin hybrids: design, synthesis, in-vitro, in-silico and SAR study for antimicrobial activity and α-glucosidase inhibition [0.03%]
新型香豆素-1,2,3-三唑-异咯酸杂化物：抗菌和α-葡萄糖苷酶抑制作用的分子设计、合成、体外、计算机辅助及构效关系研究
Mansi,Shilpa Yadav,Priyanshu et al.
Mansi et al.
Aim: The present study aims to design and synthesise novel Coumarin-1,2,3-Triazole-Isatin hybrids (9a-l) and evaluate their dual biological potential as antimicrobials and α-Glucosidase Inhibitors. ...
Design and evaluation of multi-target AGEs/ALEs inhibitors for potential application in skin anti-aging [0.03%]
多功能AGEs/ALEs抑制剂的设计与评价及其潜在的皮肤抗衰老应用研究
N André Sasaki,Pascal Sonnet
N André Sasaki
The main causes of skin aging include both intrinsic and extrinsic factors such as oxidative stress triggered by reactive oxygen species (ROS), modification of collagen and elastin by reactive carbonyl species (RCS), UV exposure, lifestyle ...