Zinc complexation improves angiotensin II receptor type 1 blockade and in vivo antihypertensive activity of telmisartan [0.03%]
锌配体复合提高了替米沙坦的血管紧张素Ⅱ受体阻断作用及降压活性
Valeria R Martínez,María V Aguirre,Juan S Todaro et al.
Valeria R Martínez et al.
Background: Angiotensin II receptor blockers were designed as therapeutic agents to block the binding site of the angiotensin II receptor type 1 (AT1R). Methodology: The structure of telmisartan was modified by coordination to the biometal ...
Wali Inam,Shelley Walton,Sheraz Khan et al.
Wali Inam et al.
Sarcoptes scabiei is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, includi...
Virtual screening and assessment of anticancer potential of selenium-based compounds against HL-60 and MCF7 cells [0.03%]
基于硒的抗肿瘤化合物虚拟筛选及HL-60和MCF7细胞抗癌活性评价
Ericka Fernanda Ferreira de Queiroz,José Alixandre de Sousa Luis,Diego de Sousa Dantas et al.
Ericka Fernanda Ferreira de Queiroz et al.
Aim: Selenium-based compounds have antitumor potential. We used a ligand-based virtual screening analysis to identify selenoglycolicamides with potential antitumor activity. Results & Conclusion: Compounds 3, 6, 7 and 8 were selected for in...
Recent developments of RET protein kinase inhibitors with diverse scaffolds as hinge binders [0.03%]
具有多种支架的近期RET蛋白激酶抑制剂的研究进展及作为铰链结合剂的作用机制
Cong-Cong Jia,Wang Chen,Zi-Li Feng et al.
Cong-Cong Jia et al.
RET is a proto-oncogene encoding a receptor tyrosine kinase. RET regulates key aspects of cellular proliferation, differentiation and survival. The activation of RET via gene fusions or point mutations is closely related to lung, thyroid an...
N-heterocyclic carbene-metal complexes as bio-organometallic antimicrobial and anticancer drugs, an update (2015-2020) [0.03%]
生物有机金属抗菌和抗肿瘤药物"N-杂环卡宾金属复合物"(2015-2020)最新进展
Siddappa A Patil,Amy P Hoagland,Shivaputra A Patil et al.
Siddappa A Patil et al.
N-heterocyclic carbenes (NHCs) are organic compounds that typically mimic the chemical properties of phosphines. NHCs have made a significant impact on the field of coordination and organometallic chemistry because they are easy to prepare ...
COVID-19 screening in a healthcare or community setting: complexity of saliva as a specimen for PCR-based testing [0.03%]
唾液作为基于PCR检测的标本在医疗或社区环境中进行Covid-19筛查的复杂性
Nikhil Shri Sahajpal,Ashis K Mondal,Allan Njau et al.
Nikhil Shri Sahajpal et al.
Novel strategies to eradicate resistant cells in chronic myeloid leukemia [0.03%]
用于清除慢性髓性白血病中耐药细胞的新策略
Anna M Schoepf,Ronald Gust
Anna M Schoepf
Robert W Huigens
Robert W Huigens
Chengcheng Xia,Weiyan Shi,Yuyu Zhang et al.
Chengcheng Xia et al.
Radiation-induced lung injury (RILI) is a common complication in cancer patients receiving local thoracic radiation and bone marrow transplantation conditioning. It is divided into early-stage radiation pneumonitis and advanced radiation fi...
In silico family-wide profiling and 3D modelling of the poly(ADP-ribose) polymerase superfamily [0.03%]
泛素连接酶RNF125通过RING结构域介导的多聚泛素化调控ACLY降解
Caleb M Kam,Amanda L Tauber,Dean L Oosthuizen et al.
Caleb M Kam et al.
Background: Due to the conserved nature of the poly(ADP-ribose) polymerase (PARP) catalytic domain, the identification of unique residues is critical for the design of selective inhibitors. With inhibitors of the DNA-dependent PARP members ...