The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes [0.03%]
细胞外核脱嘌呤/脱嘧啶内切酶1/红氧效应因子-1在反应性星形胶质细胞中的抗炎作用
Hyunjung Baek,Chae Seong Lim,Hee Sun Byun et al.
Hyunjung Baek et al.
Apurinic/apyrimidinic endonuclease 1 (APE1), a ubiquitous multipurpose protein, is also known as redox effector factor-1 (Ref-1). It is involved in DNA repair and redox signaling and, in turn, oxidative stress-induced neurodegeneration. Alt...
Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat [0.03%]
酸感受离子通道的表达及裸鼹鼠和小鼠参考基因的选择
Laura-Nadine Schuhmacher,Ewan St John Smith
Laura-Nadine Schuhmacher
Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits encoded by four genes and they are expressed throughout the peripheral and central nervous systems. ASICs have been implicated in a wide range of physi...
Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice [0.03%]
早期感觉剥夺引起的社交记忆缺陷与催产素有关
Jin-Bao Zhang,Ling Chen,Zhu-Man Lv et al.
Jin-Bao Zhang et al.
Early-life sensory input plays a crucial role in brain development. Although deprivation of orofacial sensory input at perinatal stages disrupts the establishment of the barrel cortex and relevant callosal connections, its long-term effect ...
Shigeki Ohta,Tomonori Yaguchi,Hironobu Okuno et al.
Shigeki Ohta et al.
Macrophage migration inhibitory factor (MIF) plays an important role in supporting the proliferation and/or survival of murine neural stem/progenitor cells (NSPCs); however, the downstream effectors of this factor remain unknown. Here, we s...
Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite [0.03%]
普瑞德威利症候群小鼠模型中Htr2c的替代剪接增加会导致5-羟色胺2C受体介导摄食行为的异常
Alastair S Garfield,Jennifer R Davies,Luke K Burke et al.
Alastair S Garfield et al.
Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Prader-Willi Syndrome (PWS), a ...
Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing [0.03%]
一种用于治疗药物成瘾的天然植物萃取物Heantos-4调节T型钙通道和丘脑皮层簇状放电
Stuart M Cain,Soyon Ahn,Esperanza Garcia et al.
Stuart M Cain et al.
Heantos-4 is a refined combination of plant extracts currently approved to treat opiate addiction in Vietnam. In addition to its beneficial effects on withdrawal and prevention of relapse, reports of sedation during clinical treatment sugge...
A Besse,A K Petersen,J V Hunter et al.
A Besse et al.
ABAT deficiency (OMIM 613163) is a rare inborn error of metabolism caused by recessive variants in the gene 4-aminobutyric acid transaminase (ABAT), which is responsible for both the catalysis of GABA and maintenance of nucleoside pools in ...
Case Reports
Molecular brain. 2016 Dec 1;9(1):93. DOI:10.1186/s13041-016-0273-8 2016
Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling [0.03%]
蛋白质组学分析脑退行性蛋白修饰在神经退行性疾病和痴呆病理中的作用的启示
Sunil S Adav,Siu Kwan Sze
Sunil S Adav
Dementia is a syndrome associated with a wide range of clinical features including progressive cognitive decline and patient inability to self-care. Due to rapidly increasing prevalence in aging society, dementia now confers a major economi...
ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation [0.03%]
不含 prion 结构域的神经元蛋白 ApCPEB4 通过与细胞周期蛋白相互作用启动长期增益反应
Seung-Hee Lee,Jaehoon Shim,Ye-Hwang Cheong et al.
Seung-Hee Lee et al.
Two pharmacologically distinct types of local protein synthesis are required for synapse- specific long-term synaptic facilitation (LTF) in Aplysia: one for initiation and the other for maintenance. ApCPEB, a rapamycin sensitive prion-like ...
A modulatory role of ASICs on GABAergic synapses in rat hippocampal cell cultures [0.03%]
酸敏感离子通道对大鼠海马细胞培养中GABA能突触的调节作用
Maksim Storozhuk,Elena Kondratskaya,Lyudmila Nikolaenko et al.
Maksim Storozhuk et al.
Rapid acidification occurring during synaptic vesicle release can activate acid-sensing ion channels (ASICs) both on pre- and postsynaptic neurons. In the latter case, a fraction of postsynaptic current would be mediated by cation-selective...