Josiane C S Mapplebeck,Simon Beggs,Michael W Salter
Josiane C S Mapplebeck
Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the central nervous system. Dysregulation of microglia has been critically implicated in the genesis of neuropathic pain. Peripheral nerve injury, a common ...
Rapid and stable changes in maturation-related phenotypes of the adult hippocampal neurons by electroconvulsive treatment [0.03%]
电休克治疗引起成人海马神经元与成熟相关的表型快速且稳定的变化
Yuki Imoto,Eri Segi-Nishida,Hidenori Suzuki et al.
Yuki Imoto et al.
Electroconvulsive therapy (ECT) is a highly effective and fast-acting treatment for depression. Despite a long history of clinical use, its mechanism of action remains poorly understood. Recently, a novel cellular mechanism of antidepressan...
Proteasome impairment in neural cells derived from HMSN-P patient iPSCs [0.03%]
HMSN-P患者诱导多能干细胞来源的神经细胞中的蛋白酶体损伤
Nagahisa Murakami,Keiko Imamura,Yuishin Izumi et al.
Nagahisa Murakami et al.
Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is caused by a heterozygous mutation (P285L) in Tropomyosin-receptor kinase Fused Gene (TFG), histopathologically characterized by progressive spinal motor ...
Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson's disease [0.03%]
帕金森病与α-突触核蛋白基因第一内含子低甲基化无关
Subhrangshu Guhathakurta,Baggio A Evangelista,Susmita Ghosh et al.
Subhrangshu Guhathakurta et al.
Deregulation of α-synuclein encoding gene (SNCA) is one of the important facets of Parkinson's disease (PD) research. DNA methylation status of SNCA-intron1 has been shown to regulate the α-synuclein expression. The present study is aimed...
TBK1: a new player in ALS linking autophagy and neuroinflammation [0.03%]
TBK1在ALS中的作用：连接自噬和神经炎症的新成员
James A Oakes,Maria C Davies,Mark O Collins
James A Oakes
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder affecting motor neurons, resulting in progressive muscle weakness and death by respiratory failure. Protein and RNA aggregates are a hallmark of ALS pathology ...
The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model [0.03%]
淀粉样蛋白寡聚体引起的神经毒性在原发性神经元模型中可以逆转
Daisuke Tanokashira,Naomi Mamada,Fumiko Yamamoto et al.
Daisuke Tanokashira et al.
Alzheimer's disease (AD) is characterized by the accumulation of extracellular amyloid β-protein (Aβ) and intracellular hyperphosphorylated tau proteins. Recent evidence suggests that soluble Aβ oligomers elicit neurotoxicity and synapto...
Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits [0.03%]
急性压力增强初级中央杏仁核不同微环路神经元的谷氨酸能传递
Chen Song,Wen-Hua Zhang,Xue-Hui Wang et al.
Chen Song et al.
Amygdala activation is known to be critical for the processing of stressful events in brain. Recent studies have shown that the projection neurons (PNs) in amygdala, although architecturally intermingled, are integrated into distinct microc...
Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging [0.03%]
间歇性缺氧的治疗通过与衰老共有的生物过程增加海马体中磷酸化tau蛋白含量
Sosuke Yagishita,Seiya Suzuki,Keisuke Yoshikawa et al.
Sosuke Yagishita et al.
Sleep-disordered breathing produces cognitive impairments, and is possibly associated with Alzheimer disease (AD). Intermittent hypoxia treatment (IHT), an experimental model for sleep-disordered breathing, results in cognitive impairments ...
Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway [0.03%]
Tat-HSP22通过调节线粒体途径抑制氧化应激诱导的海马神经元细胞死亡
Hyo Sang Jo,Dae Won Kim,Min Jea Shin et al.
Hyo Sang Jo et al.
Oxidative stress plays an important role in the progression of various neuronal diseases including ischemia. Heat shock protein 22 (HSP22) is known to protect cells against oxidative stress. However, the protective effects and mechanisms of...
The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture [0.03%]
背侧丘脑mGluR1-PLCβ4信号通路在调控睡眠结构中起关键作用
Joohyeon Hong,Jungryun Lee,Kiyeong Song et al.
Joohyeon Hong et al.
The transition from wakefulness to a nonrapid eye movement (NREM) sleep state at the onset of sleep involves a transition from low-voltage, high-frequency irregular electroencephalography (EEG) waveforms to large-amplitude, low-frequency EE...