ApoE isoforms differentially regulates cleavage and secretion of BDNF [0.03%]
ApoE不同亚型调节BDNF裂解和分泌的功能及机制研究
Abhik Sen,Thomas J Nelson,Daniel L Alkon
Abhik Sen
Apolipoprotein E4 (ApoE4) is a major genetic risk factor for sporadic or late onset Alzheimer's disease (AD). Brain-derived neurotrophic factor (BDNF) is decreased by 3 to 4-fold in the brains of AD patients at autopsy. ApoE4 mice also have...
Michel Goedert,Maria Grazia Spillantini
Michel Goedert
Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagation of Tau aggregates is often ...
Turtle interacts with borderless in regulating glial extension and axon ensheathment [0.03%]
龟蛋白与无界蛋白通过调节胶质细胞延伸和轴突包裹相互作用以调节神经发育
Yixu Chen,Scott Cameron,Wen-Tzu Chang et al.
Yixu Chen et al.
Proper recognition between axons and glial processes is required for the establishment of axon ensheathment in the developing nervous system. Recent studies have begun to reveal molecular events underlying developmental control of axon-glia...
Min Zhuo
Min Zhuo
The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo long-term plastic changes in ad...
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia [0.03%]
靶向代谢型谷氨酸受体研究以寻找治疗精神分裂症的新方法
James Maksymetz,Sean P Moran,P Jeffrey Conn
James Maksymetz
Support for the N-methyl-D-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease. The ability of ...
Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia [0.03%]
在小鼠中模拟自闭症的环境风险因素可诱导与肠炎相关的肠道微生物群失调和高血清素症
Joon Seo Lim,Mi Young Lim,Yongbin Choi et al.
Joon Seo Lim et al.
Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions that are sharply increasing in prevalence worldwide. Intriguingly, ASD is often accompanied by an array of systemic aberrations including (1) increased serotonin, (2...
Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation [0.03%]
不含多发性硬化症突变的Polr3a等位基因可使小鼠免于出现神经异常症状
Karine Choquet,Sharon Yang,Robyn D Moir et al.
Karine Choquet et al.
Recessive mutations in the ubiquitously expressed POLR3A gene cause one of the most frequent forms of childhood-onset hypomyelinating leukodystrophy (HLD): POLR3-HLD. POLR3A encodes the largest subunit of RNA Polymerase III (Pol III), which...
Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells [0.03%]
糖皮质激素受体通过染色质重构抑制神经元细胞中神经营养因子的表达机制研究
Hui Chen,Marc Lombès,Damien Le Menuet
Hui Chen
Brain-derived neurotrophic factor (BDNF) is involved in many functions such as neuronal growth, survival, synaptic plasticity and memorization. Altered expression levels are associated with many pathological situations such as depression, e...
Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders [0.03%]
神经粒素3R451C突变通过电生理学手段在动物自闭症模型中改变脑电图谱活动模式
Jackie J Liu,Kevin P Grace,Richard L Horner et al.
Jackie J Liu et al.
Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an imbalance in synaptic excitati...
Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing [0.03%]
人脑与非人灵长类动物脑的A到I编辑的比较分析揭示了RNA编辑的保守模式和基于上下文的调节规律
Richard T O&#x;Neil,Xiaojing Wang,Michael V Morabito et al.
Richard T O&#x;Neil et al.
A-to-I RNA editing is an important process for generating molecular diversity in the brain through modification of transcripts encoding several proteins important for neuronal signaling. We investigated the relationships between the extent ...
Comparative Study
Molecular brain. 2017 Apr 6;10(1):11. DOI:10.1186/s13041-017-0291-1 2017