Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain [0.03%]
机械生长因子，一种IGF-1的变异体，促进衰老小鼠大脑神经元生成
Jason J Tang,Jewel L Podratz,Miranda Lange et al.
Jason J Tang et al.
Mechano growth factor (MGF) is a splice variant of IGF-1 first described in skeletal muscle. MGF induces muscle cell proliferation in response to muscle stress and injury. In control mice we found endogenous expression of MGF in neurogenic ...
Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice [0.03%]
NF1突变小鼠海马MAPK活性和功率谱的昼夜节律震荡异常
Lei Chen,Tatiana Serdyuk,Beimeng Yang et al.
Lei Chen et al.
Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1 +/-) displayed enhanced MAPK ac...
Christine N Yohn,Mark M Gergues,Benjamin Adam Samuels
Christine N Yohn
Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In...
Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage [0.03%]
血红素分子作为星形胶质细胞TLR2内源性激动剂促进脑出血后继发性脑损伤
Hyunjung Min,Boomin Choi,Yong Ho Jang et al.
Hyunjung Min et al.
Toll-like receptor 2 (TLR2) was recently shown to contribute to secondary brain damage after intracerebral hemorrhage (ICH), although the molecular mechanisms of this contribution are elusive. In this study, we tested the hypothesis that he...
Robert Nisticò,Eric Salter,Celine Nicolas et al.
Robert Nisticò et al.
Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in normal and pathological situations. ...
An updated assessment of microglia depletion: current concepts and future directions [0.03%]
小胶质细胞耗竭的最新评估：当前概念和未来方向
Jinming Han,Robert A Harris,Xing-Mei Zhang
Jinming Han
Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment microglia ...
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar characteristic of physiological apoptosis and can be regulated by neuronal activity [0.03%]
氯胺酮诱发的小鼠大脑皮层凋亡具有生理凋亡的特征并受神经元活动调节
Qi Wang,Feng-Yan Shen,Rong Zou et al.
Qi Wang et al.
The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs during this developmental window, it is important to determine whether ...
Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms [0.03%]
ALS患者诱导多能干细胞衍生的星形胶质细胞通过非自主机制损害自噬作用
Martin Madill,Katya McDonagh,Jun Ma et al.
Martin Madill et al.
Amyotrophic lateral sclerosis, a devastating neurodegenerative disease, is characterized by the progressive loss of motor neurons and the accumulation of misfolded protein aggregates. The latter suggests impaired proteostasis may be a key f...
Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex [0.03%]
血清素诱导的前扣带回皮层兴奋性突触传递抑制的特征分析研究报告
Zhen Tian,Manabu Yamanaka,Matteo Bernabucci et al.
Zhen Tian et al.
Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion. ACC neurons receive innervation of projecting seroto...
Rong Wu,Xiangpen Li,Pengfei Xu et al.
Rong Wu et al.
Although post-ischemic inflammation induced by the innate immune response is considered an essential step in the progression of cerebral ischemia injury, the role of triggering receptor expressed on myeloid cells 2 (TREM2) in the pathogenes...