Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia [0.03%]
遗传删除mGlu2元突触谷氨酸受体可改善脑短暂性局灶缺血的近期预后
Federica Mastroiacovo,Slavianka Moyanova,Milena Cannella et al.
Federica Mastroiacovo et al.
We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient global ischemia, whereas receptor activation amplifies neuronal death. T...
The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress [0.03%]
大麻素受体GPR55介导急性应激小鼠眶内侧皮层的抗焦虑样作用
Qi-Xin Shi,Liu-Kun Yang,Wen-Long Shi et al.
Qi-Xin Shi et al.
The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by which GPR55 regulates anxiety and to evaluate the ...
An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias [0.03%]
基于iTRAQ的蛋白质组学分析揭示了路易体痴呆中顶叶皮质突触足蛋白的失调
Arnab Datta,Yuek Ling Chai,Jing Min Tan et al.
Arnab Datta et al.
Lewy body dementias are the second most common cause of neurodegenerative dementia in the elderly after Alzheimer's disease (AD). The two clinical subgroups of Lewy body dementias, namely, dementia with Lewy bodies (DLB) and Parkinson's dis...
Hadhimulya Asmara,Ileana Micu,Arsalan P Rizwan et al.
Hadhimulya Asmara et al.
Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium channels of the Cav3 family have t...
Juhyun Song,Daniel J Whitcomb,Byeong C Kim
Juhyun Song
Alzheimer's disease (AD) is defined by the excessive accumulation of toxic peptides, such as beta amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFT). The risk factors associated with AD include genetic mutations, aging, i...
Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14 [0.03%]
脊髓小脑共济失调14型中不需要蛋白激酶Cγ的生物学活性增强
Etsuko Shimobayashi,Josef P Kapfhammer
Etsuko Shimobayashi
Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by slowly progressive cerebellar dysfunction. Currently, 42 SCA types are known, some of which are caused by CAG repeat expansions, but others ar...
Neuroscience in the third dimension: shedding new light on the brain with tissue clearing [0.03%]
大脑三维透明化技术：照亮第三维度的神经科学
Robin J Vigouroux,Morgane Belle,Alain Chédotal
Robin J Vigouroux
For centuries analyses of tissues have depended on sectioning methods. Recent developments of tissue clearing techniques have now opened a segway from studying tissues in 2 dimensions to 3 dimensions. This particular advantage echoes heavil...
O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease [0.03%]
O-GlcNAc对自噬和α-突触核蛋白稳态的调控及其帕金森病的意义
Willayat Y Wani,Xiaosen Ouyang,Gloria A Benavides et al.
Willayat Y Wani et al.
Post-translational modification on protein Ser/Thr residues by O-linked attachment of ß-N-acetyl-glucosamine (O-GlcNAcylation) is a key mechanism integrating redox signaling, metabolism and stress responses. One of the most common neurodeg...
Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens [0.03%]
通过强化剂标准化优化触摸屏操作测试的可重复性：识别决定奖励强度的关键营养成分
Eun Woo Kim,Benjamin U Phillips,Christopher J Heath et al.
Eun Woo Kim et al.
Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to the possibility of universal sta...
SRF modulates seizure occurrence, activity induced gene transcription and hippocampal circuit reorganization in the mouse pilocarpine epilepsy model [0.03%]
SRF调节癫痫发作、诱导基因转录和海马环路重构的小鼠冰片癫痫模型研究
Pascal Lösing,Cristina Elena Niturad,Merle Harrer et al.
Pascal Lösing et al.
A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immediate early genes (IEGs) such as...