Light/dark phase-dependent spontaneous activity is maintained in dopamine-deficient mice [0.03%]
多巴胺缺乏型小鼠的昼夜节律依赖性自发活动现象
Masayo Fujita,Yoko Hagino,Taishi Takeda et al.
Masayo Fujita et al.
Dopamine is important for motor control and involved in the regulation of circadian rhythm. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last injection of L-3,4-dihydroxyphen...
Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression [0.03%]
关于LRRK2激酶通过p53诱导p21表达的研究的更正通知
Dong Hwan Ho,Hyejung Kim,Jisun Kim et al.
Dong Hwan Ho et al.
Published Erratum
Molecular brain. 2017 Oct 6;10(1):48. DOI:10.1186/s13041-017-0327-6 2017
Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis [0.03%]
缺乏CSGalNAcT1酶的小鼠的行为和神经肽网异常
Nozomu Yoshioka,Shinji Miyata,Atsushi Tamada et al.
Nozomu Yoshioka et al.
Chondroitin sulfate (CS) is an important glycosaminoglycan and is mainly found in the extracellular matrix as CS proteoglycans. In the brain, CS proteoglycans are highly concentrated in perineuronal nets (PNNs), which surround synapses and ...
Novel miR-b2122 regulates several ALS-related RNA-binding proteins [0.03%]
新型miR-b2122调节多个与ALS相关的RNA结合蛋白
Zachary C E Hawley,Danae Campos-Melo,Michael J Strong
Zachary C E Hawley
Common pathological features of amyotrophic lateral sclerosis (ALS) include cytoplasmic aggregation of several RNA-binding proteins. Out of these RNA-binding proteins, TDP-43, FUS/TLS and RGNEF have been shown to co-aggregate with one anoth...
Role of GABAA receptors in alcohol use disorders suggested by chronic intermittent ethanol (CIE) rodent model [0.03%]
慢性间歇性乙醇(CIE)动物模型提示GABA(A)受体在酒精使用障碍中的作用
Richard W Olsen,Jing Liang
Richard W Olsen
GABAergic inhibitory transmission is involved in the acute and chronic effects of ethanol on the brain and behavior. One-dose ethanol exposure induces transient plastic changes in GABAA receptor subunit levels, composition, and regional and...
General anesthetics protects against cardiac arrest-induced brain injury by inhibiting calcium wave propagation in zebrafish [0.03%]
吸入麻醉药通过抑制钙离子波传导保护斑马鱼心脏骤停所致脑损伤
Dao-Jie Xu,Bin Wang,Xuan Zhao et al.
Dao-Jie Xu et al.
Cardiac arrest is a leading cause of death and disability worldwide. Although many victims are initially resuscitated, they often suffer from serious brain injury, even leading to a "persistent vegetative state". Therefore, it is need to ex...
The DLGAP family: neuronal expression, function and role in brain disorders [0.03%]
DLGAP家族：神经元表达、功能及其在脑疾病中的作用
Andreas H Rasmussen,Hanne B Rasmussen,Asli Silahtaroglu
Andreas H Rasmussen
The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels and metabotro...
Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice [0.03%]
PV小鼠中通过视网膜刺激抑制皮层癫痫发作
Wei Jen Chang,Wei Pang Chang,Bai Chuang Shyu
Wei Jen Chang
Deep brain stimulation in thalamic regions has been proposed as a treatment for epilepsy. The electrical current excites thalamocortical activity which is controlled by γ-aminobutyric acid (GABA)ergic interneurons in the reticular thalamic...
The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila [0.03%]
ERM蛋白Moesin对于果蝇神经元形态发生及长期记忆的形成是必不可少的
Patrick S Freymuth,Helen L Fitzsimons
Patrick S Freymuth
Moesin is a cytoskeletal adaptor protein that plays an important role in modification of the actin cytoskeleton. Rearrangement of the actin cytoskeleton drives both neuronal morphogenesis and the structural changes in neurons that are requi...
Wenjuan Ru,Shao-Jun Tang
Wenjuan Ru
Human immunodeficiency virus (HIV) infection induces neuronal injuries, with almost 50% of infected individuals developing HIV-associated neurocognitive disorders (HAND). Although highly activate antiretroviral therapy (HAART) has significa...