Restoring synaptic plasticity and memory in mouse models of Alzheimer's disease by PKR inhibition [0.03%]
通过PKR抑制在阿尔茨海默病小鼠模型中恢复突触可塑性和记忆力
Kyoung-Doo Hwang,Myeong Seong Bak,Sang Jeong Kim et al.
Kyoung-Doo Hwang et al.
Alzheimer's disease (AD) is a neurodegenerative disorder associated with deficits in cognition and synaptic plasticity. While accumulation of amyloid β (Aβ) and hyper-phosphorylation of tau are parts of the etiology, AD can be caused by a...
Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability [0.03%]
Schnurri-2基因敲除小鼠海马齿状回亚细胞结构的形态学异常：精神分裂症和智力障碍模型中的发现
Akito Nakao,Naoyuki Miyazaki,Koji Ohira et al.
Akito Nakao et al.
Accumulating evidence suggests that subcellular-scale structures such as dendritic spine and mitochondria may be involved in the pathogenesis/pathophysiology of schizophrenia and intellectual disability. Previously, we proposed mice lacking...
Correction to: The role of melatonin in the onset and progression of type 3 diabetes [0.03%]
Correction to：褪黑素在3型糖尿病发病和进展中的作用
Juhyun Song,Daniel J Whitcomb,Byeong C Kim
Juhyun Song
MOLECULAR BRAIN (2017) 10:35 DOI: 10.1186/S13041-017-0315-X: In the original version of this article [1], published on 1 August 2017, Fig. 3 contains a typo. In this Correction the incorrect and correct version of Fig. 3 are shown. - Fig. 3...
Published Erratum
Molecular brain. 2017 Dec 8;10(1):59. DOI:10.1186/s13041-017-0333-8 2017
Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors [0.03%]
PKMζ活性增强抑制含GluA2的AMPA受体侧向运动
Nam-Kyung Yu,Heesoo Uhm,Jaehoon Shim et al.
Nam-Kyung Yu et al.
Protein kinase M zeta (PKMζ), a constitutively active, atypical protein kinase C isoform, maintains a high level of expression in the brain after the induction of learning and long-term potentiation (LTP). Further, its overexpression enhan...
Yuka Hama,Masataka Katsu,Ichigaku Takigawa et al.
Yuka Hama et al.
Genomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable elements within a region. CNVs are...
Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta) [0.03%]
用于识别记忆印痕分子基础的准则(CaMKII，PKMζ)
John Lisman
John Lisman
The engram refers to the molecular changes by which a memory is stored in the brain. Substantial evidence suggests that memory involves learning-dependent changes at synapses, a process termed long-term potentiation (LTP). Thus, understandi...
Lesly Puspita,Sun Young Chung,Jae-Won Shim
Lesly Puspita
Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine neurons in the substantia nigra. The reason for the death of these neurons is unclear; however, studies have demonstrated the potential involvement of mitoc...
Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage [0.03%]
丹参酮I通过抑制缺血缺氧性脑损伤后新生大鼠的氧化应激来缓解运动和认知障碍
Chunfang Dai,Yannan Liu,Zhifang Dong
Chunfang Dai
Neonatal hypoxia-ischemia is one of the main reasons that cause neuronal damage and neonatal death. Several studies have shown that tanshinone I (TsI), one of the major ingredients of Danshen, exerts potential neuroprotective effect in adul...
Direct interaction with 14-3-3γ promotes surface expression of Best1 channel in astrocyte [0.03%]
直接与14-3-3γ相互作用可促进星形胶质细胞中Best1通道的表面表达
Soo-Jin Oh,Junsung Woo,Young-Sun Lee et al.
Soo-Jin Oh et al.
Background: Bestrophin-1 (Best1) is a calcium-activated anion channel (CAAC) that is expressed broadly in mammalian tissues including the brain. We have previously reported that Best1 is expressed in hippocampal astrocyte...
Mechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation [0.03%]
雷帕霉素的机械靶标是与长期增强有关的树突棘形态变化所必需的
Fredrick E Henry,William Hockeimer,Alex Chen et al.
Fredrick E Henry et al.
Alterations in the strength of excitatory synapses in the hippocampus is believed to serve a vital function in the storage and recall of new information in the mammalian brain. These alterations involve the regulation of both functional and...