Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat [0.03%]
多精氨酸R18和R18D（D-对映体）肽可减少新生 rats 发生缺氧缺血性脑病后的脑梗死体积并改善行为预后
Adam B Edwards,Jane L Cross,Ryan S Anderton et al.
Adam B Edwards et al.
We examined the neuroprotective efficacy of the poly-arginine peptide R18 and its D-enantiomer R18D in a perinatal hypoxic-ischaemic (HI) model in P7 Sprague-Dawley rats. R18 and R18D peptides were administered intraperitoneally at doses of...
Bin Liu,Kaixing Zhou,Xiaojing Wu et al.
Bin Liu et al.
The epithalamus, which is dorsal to the thalamus, consists of the habenula, pineal gland and third ventricle choroid plexus and plays important roles in the stress response and sleep-wake cycle in vertebrates. During development, the epitha...
Expression of functional inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 by astrocytes of inferior colliculus and hippocampus [0.03%]
下丘和海马区星形胶质细胞表达功能性的抑制性神经递质转运体GlyT1、GAT-1和GAT-3
Elsa Ghirardini,Simon L Wadle,Vanessa Augustin et al.
Elsa Ghirardini et al.
Neuronal inhibition is mediated by glycine and/or GABA. Inferior colliculus (IC) neurons receive glycinergic and GABAergic inputs, whereas inhibition in hippocampus (HC) predominantly relies on GABA. Astrocytes heterogeneously express neuro...
Genetic dissection of the neuro-glio-vascular machinery in the adult brain [0.03%]
成年脑神经-胶质-血管装置的遗传构成分析
Gregory W Kirschen,Rachel Kéry,Hanxiao Liu et al.
Gregory W Kirschen et al.
The adult brain actively controls its metabolic homeostasis via the circulatory system at the blood brain barrier interface. The mechanisms underlying the functional coupling from neuron to vessel remain poorly understood. Here, we establis...
Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro [0.03%]
体外脊髓片中连接促炎症信号、突触传递和保护作用
M Medelin,V Giacco,A Aldinucci et al.
M Medelin et al.
Multiple sclerosis is characterized by tissue atrophy involving the brain and the spinal cord, where reactive inflammation contributes to the neurodegenerative processes. Recently, the presence of synapse alterations induced by the inflamma...
Alexandre Vallée,Jean-Noël Vallée
Alexandre Vallée
Autism spectrum disorder (ASD) is a neurodevelopmental disease which is characterized by a deficit in social interactions and communication with repetitive and restrictive behavior. In altered cells, metabolic enzymes are modified by the dy...
Jongjin Lee,Sangjun Park,Wooyoung Kang et al.
Jongjin Lee et al.
Super-resolution fluorescence microscopy in the current form is hard to be used to image the neural connectivity of thick tissue samples due to problems such as slow imaging speed, severe photobleaching of fluorescent probes, and high backg...
The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling [0.03%]
Rap激活因子Gef26通过抑制BMP信号调控突触生长和神经元存活
Keunjung Heo,Minyeop Nahm,Min-Jung Lee et al.
Keunjung Heo et al.
In Drosophila, precise regulation of BMP signaling is essential for normal synaptic growth at the larval neuromuscular junction (NMJ) and neuronal survival in the adult brain. However, the molecular mechanisms underlying fine-tuning of BMP ...
Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory [0.03%]
Calpain在海马中的作用对情境恐惧记忆的巩固、重新巩固但不是消退是必需的
Taikai Nagayoshi,Kiichiro Isoda,Nori Mamiya et al.
Taikai Nagayoshi et al.
Memory consolidation, reconsolidation, and extinction have been shown to share similar molecular signatures, including new gene expression. Calpain is a Ca2+-dependent protease that exerts its effects through the proteolytic cleavage of tar...
Characterization of excitatory synaptic transmission in the anterior cingulate cortex of adult tree shrew [0.03%]
成人树鼩前扣带回皮层兴奋性突触传递的特征研究
Xu-Hui Li,Qian Song,Qi-Yu Chen et al.
Xu-Hui Li et al.
The tree shrew, as a primate-like animal model, has been used for studying high brain functions such as social emotion and spatial learning memory. However, little is known about the excitatory synaptic transmission in cortical brain areas ...