Duox mediates ultraviolet injury-induced nociceptive sensitization in Drosophila larvae [0.03%]
果蝇幼虫Duox介导紫外线损伤诱导的痛觉过敏现象
Wijeong Jang,Minwoo Baek,Yeon Soo Han et al.
Wijeong Jang et al.
Background: Nociceptive sensitization is an increase in pain perception in response to stimulus. Following brief irradiation of Drosophila larvae with UV, nociceptive sensitization occurs in class IV multiple dendritic (m...
Vitamin A bio-modulates apoptosis via the mitochondrial pathway after hypoxic-ischemic brain damage [0.03%]
维生素A通过线粒体途径生物调节缺氧缺血性脑损伤后的细胞凋亡
Wei Jiang,Min Guo,Min Gong et al.
Wei Jiang et al.
Our previous studies demonstrated that vitamin A deficiency (VAD) can impair the postnatal cognitive function of rats by damaging the hippocampus. The present study examined the effects of retinoic acid (RA) on apoptosis induced by hypoxic-...
Qiu Jing Wu,Michael Tymianski
Qiu Jing Wu
NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatments. However, recent research on...
Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington's disease [0.03%]
抑制DREAM-ATF6相互作用可延缓亨廷顿舞蹈病小鼠模型认知缺陷的出现
Alejandro López-Hurtado,Daniel F Burgos,Paz González et al.
Alejandro López-Hurtado et al.
The transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a multifunctional neuronal calcium sensor (NCS) that controls Ca2+ and protein homeostasis through gene regulation and protein-protein interactions....
Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression [0.03%]
新产期抑郁模型中特异型转运蛋白配体ZBD-2的抗抑郁样作用研究
Xu-Bo Li,An Liu,Le Yang et al.
Xu-Bo Li et al.
The 18 kDa translocator protein (TSPO) is primarily localized in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. One of the protein's main functions is transporting substrate cho...
TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice [0.03%]
慢性约束损伤小鼠中 toll 样受体 4 介导的自噬抑制参与神经病理性疼痛形成
Yibo Piao,Do Hyeong Gwon,Dong-Wook Kang et al.
Yibo Piao et al.
Neuropathic pain is a complex, chronic pain state characterized by hyperalgesia, allodynia, and spontaneous pain. Accumulating evidence has indicated that the microglial Toll-like receptor 4 (TLR4) and autophagy are implicated in neurodegen...
Soluble Aβ1-42 increases the heterogeneity in synaptic vesicle pool size among synapses by suppressing intersynaptic vesicle sharing [0.03%]
可溶性Aβ1-42通过抑制突触间囊泡共享增加突触小泡池大小异质性
Daehun Park,Sunghoe Chang
Daehun Park
Growing evidence has indicated that prefibrillar form of soluble amyloid beta (sAβ1-42) is the major causative factor in the synaptic dysfunction associated with AD. The molecular changes leading to presynaptic dysfunction caused by sAβ1-...
Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson's disease-like motor dysfunction [0.03%]
黑质多巴胺能神经元的生长抑素受体下调导致类似帕金森病运动功能障碍
Yukari Suda,Naoko Kuzumaki,Takefumi Sone et al.
Yukari Suda et al.
Ghrelin exerts a wide range of physiological actions throughout the body and appears to be a promising target for disease therapy. Endogenous ghrelin receptors (GHSRs) are present in extrahypothalamic sites including the substantia nigra pa...
Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats [0.03%]
树脂衍生物D2保护rats的脑缺血再灌注损伤
Gang Zuo,Dongping Zhang,Rutao Mu et al.
Gang Zuo et al.
Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke patients. ω-3 fatty acid supplements taken as part of a daily diet have been shown to improve the prognosis of patients with is...
Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease [0.03%]
人分泌型淀粉样前体蛋白α lentiviral 表达介导的表达防止了阿尔茨海默病小鼠模型记忆力和可塑性缺陷的发展
Valerie T Y Tan,Bruce G Mockett,Shane M Ohline et al.
Valerie T Y Tan et al.
Alzheimer's disease (AD) is a neurodegenerative disease driven in large part by accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product amyloid-β peptide (Aβ). However, AD is also characterised by reducti...