BDNF genotype associated with changes in cortical thickness, severity of symptoms, and cognitive impairments in mild traumatic brain injury [0.03%]
BDNF基因与轻度脑外伤相关的皮层厚度改变、症状严重程度和认知障碍的关系
Lei Shi,Yizhen Pan,Jie Yuan et al.
Lei Shi et al.
Objective: Brain-derived neurotrophic factor (BDNF) is a critical blood protein for brain function; however, its genotypic influence on clinical outcomes and brain structure following mild traumatic brain injury (mTBI) re...
Exploration of schizophrenia-related behavioral and molecular abnormalities in a mutant mouse model with a mutation in the TVV motif of the ErbB4 gene [0.03%]
携带ErbB4基因TVV基序突变的小鼠在行为学及分子生物学异常与精神分裂症的相关性研究
Abdul Aziz Khan,Shuai Wang,Ziying Wang et al.
Abdul Aziz Khan et al.
The ErbB4 gene is a schizophrenia (SCZ) risk gene that interacts with PSD-95 via its C-terminus, a connection disrupted in SCZ patients. To investigate the functional significance of this interaction, we generated a zygotic mutant mouse lac...
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway [0.03%]
电针通过调节BDNF/ERK/mTOR信号通路旁海马区突触可塑性改善慢性不可预测温和应激大鼠抑郁样行为研究
Simin Yan,Jia Liu,Tiansheng Zhang et al.
Simin Yan et al.
Acupuncture has been found to alleviate depressive behaviors caused by chronic unpredictable mild stress (CUMS) in rats. This study explores how acupuncture improves depressive behaviors by modulating synaptic plasticity in the lateral habe...
Shangsong Yang,Yuxiong Chen,Jialin Tang et al.
Shangsong Yang et al.
Ischemic stroke, the most prevalent form of stroke, severely impacts human health due to its high incidence, disability, and mortality rates. The complex pathological response to ischemic stroke involves the interplay of various cells and t...
Integrated molecular data analysis confirms PDK1 as a candidate risk factor in ALS pathophysiology [0.03%]
整合分子数据分析确认PDK1是ALS病理生理的候选风险因素
Yuqian Liu,Ruiyun Guo,Ni Wang et al.
Yuqian Liu et al.
Combining cellular, animal, and MR analyses from three independent cohorts, we identified PDK1 as a consistent risk factor for ALS development, highlighting its potential as a therapeutic target. To further elucidate PDK1's pathogenic mecha...
Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition [0.03%]
鉴定表达VGLUT3的LTMR募集的脊髓通路以缓解瘙痒感
Xiaojing Su,Liangbiao Wang,Xiaoqing Liu et al.
Xiaojing Su et al.
Itch is a common symptom among patients suffering dermatological and systemic diseases, yet effective clinical treatments are currently lacking. Previous research has suggested that vesicular glutamate transporter 3 (VGLUT3)-lineage sensory...
Analgesic effects of transcutaneous auricular vagus nerve stimulation on partial sciatic nerve ligation-induced neuropathic pain in mice via serotonergic pathways [0.03%]
耳迷走神经经皮电刺激通过五羟色胺能通路缓解小鼠部分坐骨神经结扎诱导的神经病理性疼痛
Hyunjin Shin,Seunghwan Choi,Geehoon Chung et al.
Hyunjin Shin et al.
Current treatments for neuropathic pain often provide limited relief and are associated with significant side effects. Transcutaneous auricular vagus nerve stimulation (taVNS) shows promise as a non-pharmacological analgesic approach; howev...
Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis [0.03%]
自愿跑步改善膝关节骨关节炎前扣带回皮质突触退行性变
Ryo Miyake,Manabu Yamanaka,Wataru Taniguchi et al.
Ryo Miyake et al.
Osteoarthritis of the knee (knee OA) causes chronic pain involving peripheral tissues, the spinal cord, and the brain. Neuropathic pain leads to changes in synaptic plasticity in the anterior cingulate cortex (ACC). However, whether such ch...
Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities [0.03%]
雄性Septin 3缺陷型小鼠的行为表型分析发现任务特异性异常现象
Natsumi Ageta-Ishihara,Keizo Takao,Tsuyoshi Miyakawa et al.
Natsumi Ageta-Ishihara et al.
Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification [0.03%]
生成Slc20a2敲除小鼠品系作为原发性脑钙化的体内模型
Hisaka Kurita,Hiroki Kitaura,Kazuya Nishii et al.
Hisaka Kurita et al.
Primary brain calcification (PBC) is a neurodegenerative disease that causes bilateral ectopic calcification in the brain. In this study, using newly generated Slc20a2 knockout (Slc20a2-/-) mice, we establish an in vivo model for PBC. In co...