Functional characterization of a novel de novo CACNA1C pathogenic variant in a patient with neurodevelopmental disorder [0.03%]
具有神经发育障碍的患者的新型CACNA1C原发性致病突变的功能特征分析
Robin N Stringer,Xuechen Tang,Bohumila Jurkovicova-Tarabova et al.
Robin N Stringer et al.
Mutations in CACNA1C, the gene encoding Cav1.2 voltage-gated calcium channels, are associated with a spectrum of disorders, including Timothy syndrome and other neurodevelopmental and cardiac conditions. In this study, we report a child wit...
Case Reports
Molecular brain. 2025 Mar 25;18(1):26. DOI:10.1186/s13041-025-01195-w 2025
Neural stem cell-specific deletion of Atg7 alleviates hippocampal dysfunction and neuronal alterations induced by chronic restraint stress [0.03%]
ATG7在神经干细胞中的特异性敲除可减轻慢性束缚应激诱导的海马功能障碍和神经元异常
Hyeonjeong Jeong,Seongwon Choe,Seonghee Jung et al.
Hyeonjeong Jeong et al.
Adult hippocampal neurogenesis is inhibited by chronic psychological stress and impaired neurogenesis underlies stress-related psychological disorders. We previously reported that chronic restraint stress (CRS) evokes autophagic death of ad...
Correction: The properties of TREM1 and its emerging role in pain-related diseases [0.03%]
纠正：TREM1的性质及其在疼痛相关疾病中的作用介绍
Zhenzhen Fan,Longde Wang,Songtang Sun et al.
Zhenzhen Fan et al.
Published Erratum
Molecular brain. 2025 Mar 20;18(1):24. DOI:10.1186/s13041-025-01193-y 2025
The terpenes alpha-bisabolol and camphene modulate pruritus via an action on Cav3.2 T-type calcium channels [0.03%]
单帖烯类化合物alpha-桉树脑和石柏烯通过作用于Cav3.2 T型钙通道来调节瘙痒感
Flavia T T Antunes,Vinicius M Gadotti,Gerald W Zamponi
Flavia T T Antunes
Alpha-bisabolol and camphene have demonstrated analgesic effects in inflammatory pain models by blocking Cav3.2 calcium channels. As the pain pathway overlaps with mechanisms for itch, and because Cav3.2 channels have been associated with i...
The psychedelic psilocybin and light exposure have similar and synergistic effects on gene expression patterns in the visual cortex [0.03%]
致幻剂裸盖菇素和光暴露对视觉皮层的基因表达模式有相似的和协同的作用
Ram Harari,Dmitriy Getselter,Evan Elliott
Ram Harari
Psilocybin, a psychedelic compound found in specific hallucinogenic mushrooms, is known to induce changes in visual perception and experience in humans. However, there is little knowledge of the molecular mechanisms through which psilocybin...
Moderate ethanol exposure disrupts energy homesotasis between central and peripheral system in APP/PS1 mice [0.03%]
适量的乙醇暴露会破坏APP / PS1小鼠中枢和外周系统之间的能量稳态
Shinwoo Kang,Jeyeon Lee,Paul H Min et al.
Shinwoo Kang et al.
To investigate the effects of moderate ethanol exposure on glucose metabolism in APP/PS1 mice, an early-onset Alzheimer's disease (AD) mouse model, we employed an fluoro-deoxy-glucose (FDG)-micro-positron emission tomography (PET). We also ...
Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition [0.03%]
病毒介导的生物活性肽表达抑制ERK1/2的核功能可削弱学习消退但不削弱习得过程
Bar Izkovich,Adonis Yiannakas,Sapir Ne&#x;eman et al.
Bar Izkovich et al.
Peptide drug technologies offer powerful approaches to develop potent and selective lead molecules for therapeutic and research applications. However, new and optimized delivery approaches are necessary to overcome current pitfalls includin...
Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism [0.03%]
神经突触素-神经蛋白复合物的分析支持在自闭症小鼠模型中β-神经突触素-1功能障碍具有亚型特异性作用
Francisco Arias-Aragón,Estefanía Robles-Lanuza,Ángela Sánchez-Gómez et al.
Francisco Arias-Aragón et al.
Neurexins are presynaptic plasma membrane proteins that regulate key aspects of synapse physiology through the formation of transcellular complexes with postsynaptic ligands, including neuroligins (Nlgns). Each neurexin gene (NRXN1-3) gener...
Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction [0.03%]
向腹内侧前额叶皮层投射的核结合神经元在厌恶记忆消退过程中的特异性神经反应
Yuki Mochizuki,Asuka Joji-Nishino,Kazuo Emoto et al.
Yuki Mochizuki et al.
Animals adaptively regulate aversive memories in safe environments through extinction, a process central to exposure therapy for anxiety disorders. The limbic thalamus controls cognitive function in concert with interconnected cortical and ...
Quercetin carbon quantum dots: dual-target therapy for intracerebral hemorrhage in mice [0.03%]
槲皮素碳量子点：小鼠脑出血的双重靶向治疗
Guangyu Jia,Xinyu Yang,Yamei Yu et al.
Guangyu Jia et al.
Following intracerebral hemorrhage, mitigating oxidative stress and removing excess iron are critical strategies for reducing secondary brain injury and improving neurological outcomes. In vitro, we synthesized quercetin-ethylenediamine car...