Shamprasad Varija Raghu,Farhan Mohammad,Jia Yi Chua et al.
Shamprasad Varija Raghu et al.
The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species-most notably Drosophila-neurogeneticists identify and isolate neural circuits with a binary hete...
Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits [0.03%]
多种肌球蛋白与钠钾泵α1亚基相互作用
Bhagirathi Dash,Sulayman D Dib-Hajj,Stephen G Waxman
Bhagirathi Dash
The alpha1 (α1) subunit of the sodium/potassium ATPase (i.e., Na+/K+-ATPase α1), the prototypical sodium pump, is expressed in each eukaryotic cell. They pump out three sodium ions in exchange for two extracellular potassium ions to estab...
Stimulation-induced structural changes at the nucleus, endoplasmic reticulum and mitochondria of hippocampal neurons [0.03%]
海马神经元的刺激诱导核内、内质网和线粒体结构变化
Jung-Hwa Tao-Cheng
Jung-Hwa Tao-Cheng
Neurons exhibit stimulation-induced ultrastructural changes such as increase of thickness and curvature of the postsynaptic density, decrease in contact area between subsurface cistern and plasma membrane, and formation of CaMKII clusters a...
Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs [0.03%]
ALS相关microRNA对人类NEFM和NEFH mRNA稳定性的干扰作用分析
Danae Campos-Melo,Zachary C E Hawley,Michael J Strong
Danae Campos-Melo
Neurofilaments (NFs) are the most abundant cytoskeletal component of vertebrate myelinated axons. NFs function by determining axonal caliber, promoting axonal growth and forming a 3-dimensional lattice that supports the organization of cyto...
Relationships between the acoustic startle response and prepulse inhibition in C57BL/6J mice: a large-scale meta-analytic study [0.03%]
关于C57BL/6J小鼠听性惊跳反应与预脉冲抑制关系的元分析研究
Hirotaka Shoji,Tsuyoshi Miyakawa
Hirotaka Shoji
Prepulse inhibition (PPI) is the suppression of a startle reflex response to a startle stimulus that occurs when a weak prepulse stimulus precedes the startle stimulus. PPI is measured to assess sensorimotor gating across species, including...
Meta-Analysis
Molecular brain. 2018 Jul 13;11(1):42. DOI:10.1186/s13041-018-0382-7 2018
The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration [0.03%]
小鼠自身免疫性脑脊髓炎和谷氨酸诱导的神经元退行性变模型中的TRPM4离子通道研究
Beatrice Bianchi,Paul A Smith,Hugues Abriel
Beatrice Bianchi
Transient receptor potential melastatin member 4 (TRPM4), a Ca2+-activated nonselective cation channel, has been found to mediate cell membrane depolarization in immune response, insulin secretion, cardiovascular diseases, and cancer. In mu...
Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats [0.03%]
大鼠背根神经节神经元中TRAAK、TREK-1和TREK2通道的表达及温度敏感性漏式K+电流的特性分析
Viacheslav Viatchenko-Karpinski,Jennifer Ling,Jianguo G Gu
Viacheslav Viatchenko-Karpinski
Leak K+ currents are mediated by two-pore domain K+ (K2P) channels and are involved in controlling neuronal excitability. Of 15 members of K2P channels cloned so far, TRAAK, TREK-1, and TREK-2 are temperature sensitive. In the present study...
Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein [0.03%]
与路易体痴呆相关突变β-突触核蛋白小鼠模型海马区的分子表达模式类似未成熟神经元
Hideo Hagihara,Masayo Fujita,Juzoh Umemori et al.
Hideo Hagihara et al.
Aim: Maturation abnormalities of the brain cells have been suggested in several neuropsychiatric disorders, including schizophrenia, bipolar disorder, autism spectrum disorders, and epilepsy. In this study, we examined th...
Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells [0.03%]
白细胞介素-1β通过Wnt5a/RhoA/JNK信号通路促进皮质神经祖细胞的神经元分化
Shin-Young Park,Min-Jeong Kang,Joong-Soo Han
Shin-Young Park
Pro-inflammatory cytokine interleukin-1 beta (IL-1β) is a key mediator of inflammation and stress in the central nervous system (CNS), and is highly expressed in the developing brain. In this study, we investigated the possible role of IL-...
Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling [0.03%]
慢性束缚应激通过损害胰岛素信号诱发海马记忆缺损
Hanwoong Woo,Caroline Jeeyeon Hong,Seonghee Jung et al.
Hanwoong Woo et al.
Chronic stress is a psychologically significant factor that impairs learning and memory in the hippocampus. Insulin signaling is important for the development and cognitive function of the hippocampus. However, the relation between chronic ...