Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia [0.03%]
Schnurri-2基因敲除小鼠海马齿状回的双向短期可塑性减弱：精神分裂症模型研究
Katsunori Kobayashi,Tsuyoshi Takagi,Shunsuke Ishii et al.
Katsunori Kobayashi et al.
The dentate gyrus of the hippocampus has been implicated in the pathophysiological basis of neuropsychiatric disorders including schizophrenia. We have identified several mouse models of neuropsychiatric disorders with robust molecular and ...
Plasticity changes in forebrain activity and functional connectivity during neuropathic pain development in rats with sciatic spared nerve injury [0.03%]
坐骨神经部分损伤大鼠的神经病理性疼痛发生发展过程中大脑皮层可塑性变化研究
Tzu-Hao Harry Chao,Jyh-Horng Chen,Chen-Tung Yen
Tzu-Hao Harry Chao
Neuropathic pain is a major worldwide health problem. Although central sensitization has been reported in well-established neuropathic conditions, information on the acute brain activation patterns in response to peripheral nerve injury is ...
Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice [0.03%]
Fmr1基因敲除小鼠岛叶皮层中谷氨酸kainate受体突触功能减弱
Shuang Qiu,Yu Wu,Xinyou Lv et al.
Shuang Qiu et al.
Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP). Kainate receptor (KAR) is a subfamily of ionotropic glutamate receptors (iGluR) that acts mainly as a neuromodulator of synaptic transmission and neuro...
Depressive symptoms are associated with a functional polymorphism in a miR-433 binding site in the FGF20 gene [0.03%]
抑郁症的症状与FGF20基因中miR-433结合位点的功能多态性相关
Karen M Jiménez,Angela J Pereira-Morales,Ana Adan et al.
Karen M Jiménez et al.
Genetic studies of major depressive disorder and its associated endophenotypes are useful for the identification of candidate genes. In recent years, variations in non-coding RNA genes, such as miRNAs, have been explored as novel candidates...
The effect of Neuroligin-2 absence on sleep architecture and electroencephalographic activity in mice [0.03%]
神经胶质蛋白-2缺失对小鼠睡眠结构和脑电活动的影响
Bong Soo Seok,Feng Cao,Erika Bélanger-Nelson et al.
Bong Soo Seok et al.
Sleep disorders are comorbid with most psychiatric disorders, but the link between these is not well understood. Neuroligin-2 (NLGN2) is a cell adhesion molecule that plays roles in synapse formation and neurotransmission. Moreover, NLGN2 h...
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor [0.03%]
大麻二酚通过σ-1受体增强吗啡镇痛作用并减轻NMDA介导的癫痫发作及卒中损伤
María Rodríguez-Muñoz,Yara Onetti,Elsa Cortés-Montero et al.
María Rodríguez-Muñoz et al.
Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases, such as Alzheimer's and Parkinson's, is...
3D imaging of PSD-95 in the mouse brain using the advanced CUBIC method [0.03%]
使用先进CUBIC方法对小鼠大脑中的PSD-95进行三维成像
Huazheng Liang,Hongqin Wang,Shaoshi Wang et al.
Huazheng Liang et al.
Aims: Postsynaptic density - 95 kDa protein (PSD95) is an important molecule on the postsynaptic membrane. It interacts with many other proteins and plays a pivotal role in learning and memory formation. Its distribution ...
Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain [0.03%]
通过敲低前脑兴奋性神经元中的SIRT6提高小鼠的情境恐惧记忆
Hyopil Kim,Hyun-Seok Kim,Bong-Kiun Kaang
Hyopil Kim
A class of NAD-dependent protein deacetylases, the Sirtuin (SIRT) family of proteins is involved in aging, cell survival, and neurodegeneration. Recently, SIRT proteins, including SIRT6, have been reported to be important in learning and me...
Jing Liu,Lili Tong,Shuangshuang Song et al.
Jing Liu et al.
Pediatric refractory epilepsy is a broad phenotypic spectrum with great genetic heterogeneity. Next-generation sequencing (NGS) combined with Sanger sequencing could help to understand the genetic diversity and underlying disease mechanisms...
Control of occlusion of middle cerebral artery in perinatal and neonatal mice with magnetic force [0.03%]
磁力控制新生鼠大脑中动脉的血流阻断反应
Jie-Min Jia,Chuanqi Peng,Yihui Wang et al.
Jie-Min Jia et al.
Ischemic perinatal stroke (IPS) is common, resulting in significant mortality and morbidity. In such cases, the incidence of unilateral arterial cerebral infarction is often occluded in the middle cerebral artery (MCA), leading to focal isc...