Sonication dissociates the synaptic cleft and allows purification of postsynaptic densities with associated postsynaptic membrane [0.03%]
超声波能分开突触间隙并允许纯化与突触后膜相关的致密核心颗粒突触囊泡
Ayse Dosemeci,Jung-Hwa Tao-Cheng
Ayse Dosemeci
In the synaptic junction, pre-and post compartments are anchored to each other through trans-synaptic bridges spanning the synaptic cleft. Here we demonstrate that mild mechanical disturbance through sonication dissociates the synaptic clef...
Targeting CD74 in microglia to modulate experimental cerebral ischemia and reperfusion injury: insights from Single-Cell and bulk transcriptomics [0.03%]
靶向微胶质细胞的CD74以调节实验性脑缺血再灌注损伤：来自单细胞和批量转录组学的见解
Chang Cao,Ting Liu,Lu Peng et al.
Chang Cao et al.
Ischemic stroke remains a leading cause of mortality and long-term disability, with reperfusion injury contributing significantly to poor clinical outcomes. Microglia, the primary immune cells of the central nervous system, play a dual role...
Dae-Si Kang,Ja Wook Koo
Dae-Si Kang
Fear memory formation is crucial for survival, with the hippocampus playing a central role. This study investigates the behavioral and molecular aspects of fear memory formation, focusing on Dual-specificity tyrosine phosphorylation-regulat...
Gastrin-releasing peptide is essential for generalization of auditory conditioned fear under stress [0.03%]
应激条件下胃泌素释放肽对听觉恐惧条件作用泛化的介导作用不可或缺
Yi Wu,Xiance Ni,Hisashi Mori et al.
Yi Wu et al.
Fear generalization, which allows animals to respond adaptively to cues similar to original threatening ones, is generally beneficial for survival. However, an inability to distinguish between threat and safety, leading to the overgeneraliz...
Phosphorylated septin 3 delocalizes from the spine base and facilitates endoplasmic reticulum extension into spines via myosin-Va [0.03%]
丝氨酸磷酸化的Septin 3从突触棘根部分离并通过肌球蛋白Va促进内质网侧向延伸至突触棘
Natsumi Ageta-Ishihara,Masato Mizukami,Itsuki Kinoshita et al.
Natsumi Ageta-Ishihara et al.
Cytoskeletal remodeling drives morphological changes. Septin cytoskeleton assembles into hetero-oligomers. We previously demonstrated that late-phase long-term potentiation (L-LTP) induces smooth endoplasmic reticulum (sER) extension into d...
Synergistic actions of corticosterone and BDNF on rat hippocampal LTP [0.03%]
皮质酮和脑源性神经营养因子(BDNF)对大鼠海马长时程增强(LTP)的协同作用
Jonathan S Thacker,Liam T Ralph,Laura Koek et al.
Jonathan S Thacker et al.
Exercise evokes many physiological changes, including the release of hormones and growth factors that are known to improve cognition via unknown mechanisms. Here, we have compared the ability of two physiologically relevant factors, cortico...
Chlorpromazine directly inhibits Kv1.3 channels by facilitating the inactivation of channels [0.03%]
氯丙嗪通过促进通道失活直接抑制Kv1.3通道
Seo-In Park,Soobeen Hwang,Young Lee et al.
Seo-In Park et al.
Kv1.3 channels in microglia are pivotal in regulating neuroinflammation. The antipsychotic chlorpromazine (CPZ) demonstrates anti-inflammatory effects by decreasing Kv1.3 activity in mPFC microglia. However, the precise mechanism of CPZ's e...
Hes5+ astrocytes potentiate primary afferent Aδ and C fiber-mediated excitatory synaptic transmission to spinal lamina I neurons [0.03%]
Hes5+星形胶质细胞促进脊髓I板层神经元的一类和C纤维介导的兴奋性突触传递
Itsuki Kagiyama,Sawako Uchiyama,Makoto Tsuda
Itsuki Kagiyama
Astrocytes are critical in regulating synaptic transmission in the central nervous system (CNS). The spinal dorsal horn (SDH) is a crucial region that processes and integrates somatosensory information from the periphery and transmits it to...
The absence of Neuroligin-1 shapes wake/sleep architecture, rhythmic and arrhythmic activities of the electrocorticogram in female mice [0.03%]
神经胶质缺失形塑雌性小鼠醒/睡结构、脑电图周期性和非周期性活动
Cassandra C Areal,Nicolas Lemmetti,Tanya Leduc et al.
Cassandra C Areal et al.
Associated to glutamatergic neurotransmission, Neuroligin-1 (NLGN1) is a synaptic adhesion molecule with roles in the regulation of behavioral states and cognitive function. It was shown to shape electrocorticographic (ECoG) activity during...
Heterogeneity in pericyte inflammatory responses across age and species highlight the importance of human cell models [0.03%]
不同年龄和物种中周细胞炎症反应的异质性凸显了人类细胞模型的重要性
Taylor J Stevenson,Kahee Lee,Susan Li et al.
Taylor J Stevenson et al.
Pericytes in the central nervous system are essential for maintaining blood-brain barrier function, regulating blood flow, modulating immune responses, and interacting closely with surrounding cells of the neurovascular unit to support brai...