Visualization of the existence of LEAP2 in the nucleus accumbens and its role in amphetamine-induced locomotor activity [0.03%]
LEAP2在伏隔核中的定位及其在冰毒致小鼠异常运动行为中作用的初步研究
Seohyeon Lee,Ga Young Yoo,Hyung Shin Yoon et al.
Seohyeon Lee et al.
The nucleus accumbens (NAcc) is a key brain region in reward circuitry, mediating responses to psychostimulants, such as amphetamine (AMPH), including locomotor activity. This effect is known to be enhanced by the orexigenic neuropeptide gh...
CSF Amyloid-β42 associates with neuropsychiatric and cognitive outcomes via cerebral glucose metabolism [0.03%]
脑葡萄糖代谢介导CSF Aβ42与神经精神和认知结果之间的关系
Ali Azargoonjahromi,Hamide Nasiri;Alzheimer’s Disease Neuroimaging Initiative#
Ali Azargoonjahromi
Amyloid-β42 (Aβ42) regulates synaptic plasticity and memory formation at physiological levels in the brain, but in Alzheimer's disease (AD), it can disrupt brain function and glucose metabolism. This disruption contributes to cognitive de...
The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics [0.03%]
内侧前额叶皮层通过序列神经元动态编码程序规则
Shuntaro Ohno,Masanori Nomoto,Kaoru Inokuchi
Shuntaro Ohno
The prefrontal cortex plays a crucial role in procedural rule learning; however, the specific neuronal mechanism through which it represents rules is unknown. We hypothesized that sequential neuronal activities in the prefrontal cortex enco...
Systemic semaglutide provides a mild vasoprotective and antineuroinflammatory effect in a rat model of ocular hypertensive glaucoma [0.03%]
系统性塞meglutide在实验性青光眼模型中具有轻度血管保护和抗神经炎症作用
Zaynab A Mouhammad,Anne Rombaut,Mariana Yolotzin García Bermúdez et al.
Zaynab A Mouhammad et al.
Glaucoma is a neurodegenerative disease affecting retinal ganglion cells (RGCs), with a multifactorial genesis that includes inflammation and vascular dysfunction. Emerging evidence suggests that glucagon-like peptide 1 receptor agonist (GL...
Distinct composition of different types of Abeta plaques in the pathogenesis of Alzheimer's disease and the role of neutrophil-derived myeloperoxidase [0.03%]
阿尔茨海默病发病机制中不同类型的淀粉样蛋白斑组成及中性粒细胞来源髓过氧化物酶的作用
Jianru Sun,Xiangqi Shao,Xue Wang et al.
Jianru Sun et al.
Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Different types of Aβ plaques are likely to play distinct roles in the brains of patients with AD. In this study, through the combination of pathological techniques and...
Effects of vincristine on the properties of low threshold mechanoreceptors and high threshold mechanoreceptors in the hindpaw glabrous skin of mice [0.03%]
长春新碱对小鼠后爪光滑皮肤低阈值机械感受器和高阈值机械感受器性质的影响
Akihiro Yamada,Ayaka I Yamada,Jennifer Ling et al.
Akihiro Yamada et al.
Vincristine is an important chemotherapy drug to treat various types of cancer, but it induces peripheral neuropathy, leading to numbness and mechanical allodynia in the hands and feet of patients. The peripheral neuropathy is a dose-limiti...
Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D1-like receptor signaling [0.03%]
慢性自愿运动诱导去甲肾上腺素激活多巴胺D1样受体信号转导的可塑性
Katsunori Kobayashi
Katsunori Kobayashi
Physical exercise has lasting positive influence on mental health. However, its cellular substrate remains to be elucidated. Recently, dopamine D1-like receptor activation induced by noradrenaline has been suggested to underlie exercise-dep...
Recent developments in peptide vaccines against Glioblastoma, a review and update [0.03%]
胶质母细胞瘤肽疫苗近期研究进展综述与更新
Reza Salahlou,Safar Farajnia,Effat Alizadeh et al.
Reza Salahlou et al.
Glioblastoma multiforme (GBM) is the most prevalent invasive CNS tumor, with a high incidence rate and a high likelihood of recurrence in most patients. Despite available treatments, recurrent glioblastoma (rGBM) exhibits growing resistance...
ATP stimulates appetite by enhancing the expression of hypothalamic orexigenic neuropeptides [0.03%]
ATP通过增强下丘脑促摄食神经肽的表达来刺激食欲
Nayoun Kim,Eun-Kyoung Kim
Nayoun Kim
Hypothalamic neuropeptides play a pivotal role in regulating appetite and energy homeostasis. Extracellular ATP, a key signaling molecule in the hypothalamus, is associated with neuronal activity and metabolic processes. However, its role i...
Effects of intermittent theta burst stimulation on the inflammatory response and cerebral blood flow in promoting neurovascular repair after ischemic stroke [0.03%]
经间歇式θ爆发刺激促进缺血性卒中后神经血管修复的作用及对炎症反应和脑血流的影响
Jingjun Zhang,Siyue Li,Dan Huang et al.
Jingjun Zhang et al.
Secondary injuries from ischemia‒reperfusion in stroke, such as edema and hemorrhagic transformation, can significantly impact brain function. This study investigated the effects of intermittent theta burst stimulation (iTBS) on neurologic...