Crosstalk of KCNH1 and KCNH5 gain-of-function mutations leading to epilepsy and neurodevelopmental disorders [0.03%]
KCNH1和KCNH5功能获得性突变在癫痫和神经发育障碍中的相互作用
Alisa Bernert,Philipp Rühl,Roland Schönherr et al.
Alisa Bernert et al.
Voltage-gated K+ (Kv) channels are tetrameric complexes of proteins encoded by KCN genes. Gain-of-function (GoF) mutations in KCNH1 (Kv10.1, hEAG1) and KCNH5 (Kv10.2, hEAG2) give rise to developmental disorders, intellectual disability, and...
Chronic stress increases the susceptibility to chronic vulvar pain following acute vulvar inflammation in a preclinical model of vulvodynia [0.03%]
慢性压力通过增加急性外阴炎后的慢性外阴疼痛的易感性在外阴痛小鼠模型中加剧慢性外阴痛症状
Yaseen Awad-Igbaria,Saher Abu-Ata,Renad Jabarin et al.
Yaseen Awad-Igbaria et al.
Psychological distress and chronic stress were suggested to contribute to the pathophysiology of idiopathic pain conditions such as provoked vulvodynia (PV). The comorbidity of PV and mood disorder is quite common. Thus, vulvar pain can tri...
Impairment of novelty-dependent hippocampal behavioural tagging in Septin5-deficient mice [0.03%]
Septin5缺陷型小鼠海马行为标记新奇依赖性损伤
Natsumi Ageta-Ishihara,Naoto Fukumasu,Kazuki Fujii et al.
Natsumi Ageta-Ishihara et al.
Septin-5 is a GTP-binding protein implicated in synaptic vesicle exocytosis and 22q11.2 deletion-related neuropsychiatric disorders. We recently showed that Septin5-deficient (Septin5-/-) mice display intact hippocampal spine ultrastructure...
Juan Guo,Xiaotong Yu,Yuewen Ma
Juan Guo
Recent advances in mechanotransduction research have highlighted the important role of mechanosensitive ion channels, particularly the transient receptor potential vanilloid 4 (TRPV4) channel. TRPV4, a non-selective cation channel predomina...
Insights into the interplay between stroke and depression through lipid metabolism-related diagnostic genes [0.03%]
通过脂质代谢相关诊断基因探讨卒中和抑郁之间的相互作用机制
Yun Liu,Bo Chen,Yu Yang et al.
Yun Liu et al.
Stroke, a result of acute cerebrovascular disease that causes cerebral dysfunction, often coexists with depression or even major depressive disorder (MDD). Despite the recognized significance of lipid metabolism disorders in both stroke and...
TMEM16A ablation in cholinergic medial habenula neurons induces early-onset schizophrenia-like phenotypes in mice [0.03%]
胆碱能中缝缰核神经元(TMEM16A缺失小鼠出现类似精神分裂症表型
Ajung Kim,Soomin Lee,Sangjoon Lee et al.
Ajung Kim et al.
Schizophrenia is a heterogeneous psychiatric disorder that remains inadequately treated with current therapies. Developing appropriate animal models that reflect the broad spectrum of schizophrenia symptoms is crucial for advancing our unde...
Rin-Ichiro Teruya,Kentaro Ueda,Takumi Taketomi et al.
Rin-Ichiro Teruya et al.
Microglia, the resident immune cells in the central nervous system, play important roles not only in immune response but also in neurogenesis, synaptogenesis, and neural circuit formation. Microglia also surveil the brain environment via el...
Primary cortical neurons precipitate and extrude large mitochondria-associated calcium-phosphate sheets with a bone-precursor-like ultrastructure [0.03%]
原发性皮质神经元沉淀并排出大型与线粒体相关且含有钙磷酸盐的类似骨前体的超结构薄片
Erik D Anderson,Christopher A Cronkite,Philip R Baldwin et al.
Erik D Anderson et al.
Calcium-phosphate (CaP) is a ubiquitous inorganic compound that plays an important structural role in healthy bone and teeth formation, but its pathologic buildup can occur in dyshomeostatic calcium disorders like Alzheimer's disease and Le...
Proteasome inhibition by VR23 enhances autophagic clearance of FUSP525L-mediated persistent stress granule in SH-SY5Y cells [0.03%]
蛋白酶体抑制剂VR23通过增强FUSP525L介导的持续性应激颗粒自噬清除作用保护神经细胞
Seong Hyun Kim,Jun Hee So,Yong Hwan Kim et al.
Seong Hyun Kim et al.
Autophagy is a conserved catabolic pathway that preserves cellular homeostasis through lysosomal degradation. Beyond its general role in proteostasis, selective autophagy mediates the clearance of selective cellular targets such as persiste...
Mosaic AAV mediates efficient transduction across the central and peripheral nervous systems [0.03%]
马赛克AAV能够高效地介导中枢和外周神经系统转导
Min Jiang,Wenqing Yin,Xiaolu Mo et al.
Min Jiang et al.
Adeno-associated virus (AAV) is a promising vector for neurological gene therapy, yet engineered serotypes are restricted to targeting either the central or peripheral nervous system (CNS or PNS). To overcome this limitation, we generated A...